Serum 25-Hydroxyvitamin D and the Incidence of Peripheral Artery Disease in the Elderly: The Pro.V.A Study

Veronese, Nicola; Rui, Marina De; Bolzetta, Francesco; Toffanello, Elena Debora; Coin, Alessandra; Corti, Maria Chiara; Baggio, Giovannella; Perissinotto, Egle; Maggi, Stefania; Crepaldi, Gaetano; Manzato, Enzo; Sergi, Giuseppe

doi:10.5551/jat.28134

Cited by 17 publications

(16 citation statements)

References 33 publications

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“…Three studies 13 15 18 have examined the relationship between vitamin D and PAD in the general population. Of those, two 13 15 were conducted using the US National Health and Nutrition Examination Survey (NHANES) 2001-2004 data.…”

Section: Discussionmentioning

confidence: 99%

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Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study

Kweon

Choi

et al. 2016

Chonnam Med J

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Low levels of vitamin D have been associated with increased cardiovascular disease risk. However, few studies have evaluated the association between vitamin D status and peripheral arterial disease (PAD). We therefore aimed to investigate whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with increased risk of PAD in the Korean population. This cross-sectional study was conducted among 8,960 subjects aged 50 years or older without known myocardial infarction or stroke. PAD was defined by an ankle brachial blood pressure index <0.9. Multivariate logistic regression was used to evaluate the association between serum 25(OH)D levels and risk of PAD. Of the 8,960 subjects, 3.0% had PAD and the age and sex adjusted prevalence of PAD decreased with the increasing 25(OH)D quartile. After adjusting for potential confounders and parathyroid hormones, serum 25(OH)D levels were associated with a significantly decreased risk of PAD (OR for one SD increase, 0.98; 95% CI, 0.95-1.0, P for trend=0.040). Compared with the first 25(OH)D quartile, the odds of PAD were 0.86 (95% CI, 0.62-1.21), 0.67 (95% CI, 0.46-0.97), and 0.71 (95% CI, 0.49-1.04) for the second, third, and fourth quartiles, respectively. In this cross-sectional study, we found that low serum 25(OH)D levels were associated with an increased risk of PAD, independent of traditional cardiovascular risk factors and parathyroid hormone. Our findings suggest that low vitamin D levels may contribute to PAD in the Korean population.

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Section: Discussionmentioning

confidence: 99%

“…Some prior studies have reported that low serum 25(OH)D concentrations are associated with a higher prevalence of PAD, 12 13 14 15 16 whereas others have not. 3 17 18 …”

Section: Introductionmentioning

confidence: 99%

Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study

Kweon

Choi

et al. 2016

Chonnam Med J

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“…follow-up of 4.4 years[16]. In the latter study participants with 25(OH)D concentrations <25 nmol/L had no increased risk of developing PAD as defined by an ABPI of <0.9.…”

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confidence: 83%

“…Five of these studies were excluded because PAD cases and/or non-PAD controls were not defined or 25(OH)D concentrations were not reported. One study was excluded as it was not a casecontrol investigation [16]. One study included patients with abdominal aortic aneurysm (AAA) as controls and since these individuals cannot be assumed to be healthy or not have concomitant PAD [28], this study was excluded [12].…”

Section: Selection Of Included Studiesmentioning

confidence: 99%

“…Some studies have reported that low levels of circulating 25(OH)D are associated with PAD [10][11][12][13] while others have not [2,14,15]. Furthermore, a recent study that followed up 1568 community-dwelling elderly participants for 4.4 years concluded that baseline vitamin D did not predict the onset of PAD among the 371 subjects who eventually developed the disease [16]. Currently, there is thus limited consensus regarding the association of 25(OH)D concentration with PAD.…”

Section: Introductionmentioning

confidence: 99%

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The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease: A meta-analysis of observational studies

et al. 2015

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Association of Osteoarthritis With Increased Risk of Cardiovascular Diseases in the Elderly: Findings From the Progetto Veneto Anziano Study Cohort

Veronese

Trevisan

Rui

et al. 2016

Arthritis & Rheumatology

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Objective. The possible relevance of osteoarthritis (OA) as a cardiovascular disease (CVD) risk factor is still debated. The aim of this study was to investigate the association between OA and the onset of CVD in older individuals.Methods. Among a sample of 3,099 elderly subjects, 2,158 were identified as having no CVD at baseline and were followed up for a mean 6 SD 4.4 6 1.2 years. OA was defined using a standardized algorithm that investigated disease history, medical documentation (including radiographic reports), symptoms, and physical examination of the joints. Incident CVD was defined as the onset of coronary artery disease, heart failure, stroke/transient ischemic attack, peripheral artery disease, and CVD-related hospitalization or mortality.Results. At baseline, 1,336 (61.9%) of the 2,158 study participants had OA. Participants with OA had more potential CVD risk factors, including obesity, hypertension, high levels of low-density lipoprotein, greater severity of inflammation, and worse renal function, than did those without OA. During the follow-up, 47.8% of the subjects with OA developed a new CVD event, compared to 41.3% of those without OA. Using an adjusted Cox regression analysis, the presence of OA significantly increased the risk of CVD (hazard ratio 1.22, 95% confidence interval 1.02-1.49; P 5 0.04). The association between OA and CVD was stronger when the hip or knee was affected, and also was stronger in women than in men and when ‡2 joints were involved. Considering single CVD outcomes, the presence of OA significantly increased the risk of new coronary artery disease, heart failure, and hospitalization for CVD.Conclusion. OA may be a significant predictor of the onset of CVD in elderly individuals, particularly in women with OA and when OA affects the lower limbs or ‡2 joints are involved.Osteoarthritis (OA) is a common condition in the elderly, with a prevalence ranging from 10% to 30% in individuals ages $65 years (1). OA seems to raise the risk of several negative outcomes, being associated with higher rates of hospitalization (2) and institutionalization (3), and also a higher risk of earlier death (4).A growing body of research suggests that OA might be considered to be a cardiovascular risk factor. It is associated with several risk factors for cardiovascular diseases (CVDs), such as physical inactivity, hypertension, and greater use of medication (particularly, nonsteroidal antiinflammatory drugs [NSAIDs]) (5,6). Although OA is usually classified as a noninflammatory condition (7), it is often characterized by some degree of low-grade inflammation, which seems to be a potential CVD risk factor (8).While several cross-sectional studies have shown a strong independent association between OA and CVD

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Serum 25-Hydroxyvitamin D and the Incidence of Peripheral Artery Disease in the Elderly: The Pro.V.A Study

Abstract: Aim: This study was conducted to examine whether low serum levels of 25-hydroxyvitamin D (25OHD) are associated with a higher risk of incident peripheral artery disease (PAD) in a representative group of elderly people.

Cited by 17 publications

References 33 publications

Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study

Association between Vitamin D Status and Risk of Peripheral Arterial Disease: The Dong-gu Study

The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease: A meta-analysis of observational studies

Association of Osteoarthritis With Increased Risk of Cardiovascular Diseases in the Elderly: Findings From the Progetto Veneto Anziano Study Cohort

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