The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease: A meta-analysis of observational studies

Nsengiyumva, Vianne; Fernando, Malindu E.; Moxon, Joseph V.; Krishna, Smriti Murali; Pinchbeck, Jenna; Omer, Safraz Mohamed; Morris, Dylan; Jones, Rhondda; Moran, Corey S.; Seto, Sai Wang; Golledge, Jonathan

doi:10.1016/j.atherosclerosis.2015.10.011

Cited by 48 publications

(28 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The anti-inflammatory action of vitamin D was suggested to be mediated by an effect on calcineurin-mediated responses [116](Table 1). Further, a meta-analysis comprising six case-control studies assessing 6,418 patients with PAD suggests the association of low levels of circulating vitamin D with PAD and with chronic limb ischemia [17]. Li et al [18] and Oh et al [19] also reported similar association in their studies with 1,028 diabetic patients and 8,960 subjects, respectively.…”

Section: Vascular Diseasementioning

confidence: 89%

“…Low levels of vitamin D have been associated with increased risk of CVD such as coronary artery disease (CAD) [5], myocardial infarction (MI) [6–7], hypertrophy [8], cardiomyopathy [9–10], fibrosis [11–12], heart failure (HF) [13–14]. In addition, deficiency of vitamin D has been found in arterial diseases, including aneurysm [15–16], peripheral arterial disease (PAD) [17–19], arterial calcification [20], hypertension (HTN) [21–22] and atherosclerosis [23] (Figures 2 and 3). The low levels of vitamin D in these studies may be due to different confounding factors such as environment, age, sex, socioeconomic status, and nutritional status.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

118

View full text Add to dashboard Cite

Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

show abstract

Section: Vascular Diseasementioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

118

View full text Add to dashboard Cite

show abstract

“…More recently, many studies have reported an inverse association between serum 25(OH)D levels and cardiovascular risk. Low serum 25(OH)D concentrations (namely below 50 nmol/L) have been associated with increased risk of ischemic heart disease and myocardial infarction [5,6], heart failure [7][8][9], peripheral arterial disease [10], and cerebrovascular events [11,12]. However, the results of these studies may be limited by residual bias and reverse causality.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

et al. 2020

View full text Add to dashboard Cite

This study investigated the relationship between metabolic parameters and low serum 25-hydroxyvitamin D (25(OH)D) levels in older adults (n = 265). They were assessed for anthropometrics and metabolic measurements, including 25(OH)D, insulin, glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and other inflammatory markers. Vitamin D deficiency was defined as a 25(OH)D level below 50 nmol/L. Comparisons between groups were performed using Wilcoxon–Mann–Whitney or Pearson’s Chi-squared test. A multivariate adjusted Poisson regression was used to model the number of metabolic parameters as a function of a set of explanatory variables. Subjects with 25(OH)D deficiency were predominantly females and presented higher body weight, body mass index, waist circumference, triglycerides and Tumor Necrosis Factor-α (TNF-α), and higher insulin resistance. Metabolic syndrome was also more prevalent among 25(OH)D-deficient subjects. In those without metabolic syndrome, 25(OH)D deficiency was related only to obesity and higher insulin resistance. Female sex, hypertension, higher waist circumference and higher levels of hemoglobin A1C (%), HDL-C, and TG were significantly associated with an increased number of metabolic syndrome parameters after adjusting for covariates, but 25(OH)D was not. The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition.

show abstract

“…With regard to cardiovascular disease, large epidemiological studies have routinely highlighted a link between vitamin D insufficiency or deficiency and increased risks of hypertension (Ke, Mason, Kariuki, Mpofu, & Brock, 2015), promotion of atherosclerosis (Kunadian, Ford, Bawamia, Qiu, & Manson, 2014; Nsengiyumva et al, 2015), chronic kidney disease (CKD) progression (Junarta, Jha, & Banerjee, 2019; Melamed et al, 2018), and cardiovascular mortality and morbidity (Wang, 2016; Wang et al, 2012). Vitamin D‐mediated suppression of the renin‐angiotensin‐aldosterone system (RAAS) appears to be the most likely mechanism through which vitamin D exerts its potential cardiovascular benefits.…”

Section: Introductionmentioning

confidence: 99%

Noteworthy idiosyncrasies of 1α,25‐dihydroxyvitamin D₃ kinetics for extrapolation from mouse to man: Commentary

Noh

Yang

Sekhon

et al. 2020

Biopharm & Drug Disp

View full text Add to dashboard Cite

Calcitriol or 1,25-dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] is the active ligand of the vitamin D receptor (VDR) that plays a vital role in health and disease. Vitamin D is converted to the relatively inactive metabolite, 25-hydroxyvitamin D 3 [25(OH)D 3 ], by CYP27A1 and CYP2R1 in the liver, then to 1,25(OH) 2 D 3 by a specific, mitochondrial enzyme, CYP27B1 (1α-hydroxylase) that is present primarily in the kidney. The degradation of both metabolites is mostly carried out by the more ubiquitous mitochondrial enzyme, CYP24A1. Despite the fact that calcitriol inhibits its formation and degradation, allometric scaling revealed strong interspecies correlation of the net calcitriol clearance (CL estimated from dose/AUC ∞ ), production rate (PR), and basal, plasma calcitriol concentration with body weight (BW). PBPK-PD (physiologically based pharmacokinetic-pharmacodynamic) modeling confirmed the dynamic interactions between calcitriol and Cyp27b1/Cyp24a1 on the decrease in the PR and increase in CL in mice. Close scrutiny of the literature revealed that basal levels of calcitriol had not been taken into consideration for estimating the correct AUC ∞ and CL after exogenous calcitriol dosing in both animals and humans, leading to an overestimation of AUC ∞ and underestimation of the plasma CL. In humans, CL was decreased in chronic kidney disease but increased in cancer. Collectively, careful pharmacokinetic data analysis and improved definition are achieved with PBPK-PD modeling, which embellishes the complexity of dose, enzyme regulation, and disease conditions. Allometric scaling and PBPK-PD modeling were applied successfully to extend the PBPK model to predict calcitriol kinetics in cancer patients. K E Y W O R D Sallometric scaling, calcitriol or 1,25(OH) 2 D 3 , CYP24A1, CYP27B1, pharmacokinetics

show abstract

The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease: A meta-analysis of observational studies

Cited by 48 publications

References 42 publications

Role of Vitamin D in Cardiovascular Diseases

Role of Vitamin D in Cardiovascular Diseases

Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

Noteworthy idiosyncrasies of 1α,25‐dihydroxyvitamin D₃ kinetics for extrapolation from mouse to man: Commentary

Contact Info

Product

Resources

About

The association of circulating 25-hydroxyvitamin D concentration with peripheral arterial disease: A meta-analysis of observational studies

Cited by 48 publications

References 42 publications

Role of Vitamin D in Cardiovascular Diseases

Role of Vitamin D in Cardiovascular Diseases

Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

Noteworthy idiosyncrasies of 1α,25‐dihydroxyvitamin D3 kinetics for extrapolation from mouse to man: Commentary

Contact Info

Product

Resources

About

Noteworthy idiosyncrasies of 1α,25‐dihydroxyvitamin D₃ kinetics for extrapolation from mouse to man: Commentary