Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship With Obesity and Type 2 Diabetes

Clemente‐Postigo, Mercedes; Muñoz-Garach, Araceli; Serrano, Marta; Garrido‐Sánchez, Lourdes; Bernal-López, María Rosa; Fernández-García, Diego; Moreno-Santos, Inmaculada; Garriga, Núria; Castellano‐Castillo, Daniel; Camargo, Antonio; Fernández-Real, José Manuel; Cardona, Fernando; Tinahones, Francisco J.; Macías-González, Manuel

doi:10.1210/jc.2014-3016

Cited by 93 publications

(76 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the association is still inconsistent (21). Moreover, we found a negative association between 25(OH)D and WC, WHtR, and %FM that was similar to the findings of previous studies (22,23).…”

Section: Discussionsupporting

confidence: 88%

Vitamin D Insufficiency Predicts Elevated Levels of Complement 3 Independent of Insulin Resistance and BMI

Ahmad

Al-Domi

2017

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThis study was to determine serum 25-hydroxyvitamin D (25(OH)D), the complement 3 (C3), and C-reactive protein (CRP) levels, and their association with the risk of insulin resistance (IR). A case-control study was carried out among 134 participants with body mass index (BMI) $30 kg/m 2 and BMI518.5-24.99 kg/m 2 . Anthropometric and body composition indicators were measured. Serum levels of C3, CRP, 25(OH)D, insulin, and glucose were also measured. IR was assessed by the homeostasis model assessment (HOMA-IR). C3, CRP, insulin, and HOMA-IR levels were higher in participants with obesity than that of controls (p,0.001). After adjustment for the potential confounders, anthropometric and body composition indicators were correlated positively with C3 (p,0.001), and negatively with 25(OH)D (p,0.05). C3, and 25(OH)D were correlated with r520.212; p,0.05). In logistic regression analyses, C3 and CRP were significantly related to increased odds of IR among participants with obesity as compared to controls after progressively adjusting for the potential confounders (p,0.001), whereas 25(OH)D was negatively, but insignificantly, related to decreased odds of IR among participants with obesity (p.0.05). C3 was associated positively with 25(OH)D insufficiency/deficiency independent of HOMA-IR and/or BMI (b50.183, p,0.05). Obesity is associated with elevated levels of proinflammatory biomarkers and IR. 25(OH)D insufficiency/deficiency was associated with C3 regardless of HOMA-IR or BMI, which could in turn, have a role in the augmentation of IR during obesity. Key Words adipose tissue, ASP, BIA, 25-hydroxyvitamin D deficiency, inflammation Adipose tissue is a vital endocrine organ that can affect the homeostasis of the body; it expresses several proinflammatory cytokines such as, tumor necrosis factor-alpha (TNF-a) and C-reactive protein (CRP), and anti-inflammatory factors such as adiponectin. Obesityinduced inflammation has been implicated in different cardiometabolic disorders including insulin resistance (IR) (1). The complement system is activated during the state of subclinical inflammation associated with obesity; of which the complement 3 (C3) plays the central role in all pathways; namely, the lectin, classical, and alternative pathways (2). The role of the complement system in the human immune integration is well known, yet the effect of improbable management of the complement system on health requires further investigation (2, 3). Vitamin D is a steroid hormone and its role in different segments of the body is well-established. Its deficiency has been associated with obesity as well as immune system defects and IR (4). The serum 25-hydroxyvitamin D (25(OH)D) blood level is known as a valid indicator to assess vitamin D status; whether it is deficient, sufficient or intoxicated. It has a half-life of 2-3 wk that reflects vitamin D stores over a long period and it represents the two main sources of vitamin D; food intake and sun exposure (5).To date, only one report by De Pergola et al. (4), University of Bar...

show abstract

Section: Discussionsupporting

confidence: 88%

Vitamin D Insufficiency Predicts Elevated Levels of Complement 3 Independent of Insulin Resistance and BMI

Ahmad

Al-Domi

2017

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…The considerable host of actions performed by PPARG can be compared to those of vitamin D and VDR [15], which has been implicated in neurologic disorders [16–18], autoimmune pathologies [19–21], cardiovascular disease [22], diabetes mellitus [23, 24], psoriasis [15] or infectious disease [25, 26], and, above all of what is mentioned, cancer [27, 28]. …”

Section: The Pparg Physiologymentioning

confidence: 99%

Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

2016

Self Cite

View full text Add to dashboard Cite

The PPAR nuclear receptor family has acquired great relevance in the last decade, which is formed by three different isoforms (PPARα, PPARβ/δ, and PPAR ϒ). Those nuclear receptors are members of the steroid receptor superfamily which take part in essential metabolic and life-sustaining actions. Specifically, PPARG has been implicated in the regulation of processes concerning metabolism, inflammation, atherosclerosis, cell differentiation, and proliferation. Thus, a considerable amount of literature has emerged in the last ten years linking PPARG signalling with metabolic conditions such as obesity and diabetes, cardiovascular disease, and, more recently, cancer. This review paper, at crossroads of basic sciences, preclinical, and clinical data, intends to analyse the last research concerning PPARG signalling in obesity and cancer. Afterwards, possible links between four interrelated actors will be established: PPARG, the vitamin D/VDR system, obesity, and cancer, opening up the door to further investigation and new hypothesis in this fascinating area of research.

show abstract

“…Clemente-Postigo et al [62] discovered an inverse association between serum concentrations of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and the parameters of insulin resistance, such HOMA-IR and plasma glucose levels, in patients with obesity. In a study using premenopausal women, Ferreira et al [63] showed a negative correlation between serum vitamin D levels and parameters of insulin resistance.…”

Section: Vitamin D and Insulin Resistance In Obesitymentioning

confidence: 99%

Role of vitamin D in insulin resistance in obese individuals

Santos

Lima

Braz

et al. 2017

Nutrire

View full text Add to dashboard Cite

Background: Vitamin D is a fat-soluble compound responsible for promoting intestinal absorption of calcium, and this, in turn, acts as a signal transmitter or activator as protein in secretory processes and release of hormones. Vitamin D receptors are distributed in various tissues of the body and involved in biochemical reactions in the pathogenesis of several diseases, such as obesity. Objective: The aim of this article is to provide updated information on the role of vitamin D in insulin resistance in obese individuals. Methods: It was conducted a search of articles published in PubMED, SciELO, and LILACS database, without limit for the year of publication, using the keywords "vitamin D", "insulin resistance", and "obesity". Results: Excess adipose tissue seems to impair insulin signaling by inhibiting the phosphorylation of its receptor, resulting in insulin resistance. Studies have evidenced role of vitamin D in mechanisms involved in the pathogenesis of insulin resistance in obesity by acting in improving glycemic control both by increasing hepatic and peripheral glucose uptake and by promoting the secretion of this hormone. Conclusions: Vitamin D exerts a protective effect in the treatment and prevention of insulin resistance in patients with obesity and protects the body against oxidative stress and chronic inflammation, contributing to glycemic control. Unfortunately, current data related to the effects of vitamin D supplementation on insulin resistance are still inconclusive.

show abstract

Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship With Obesity and Type 2 Diabetes

Cited by 93 publications

References 20 publications

Vitamin D Insufficiency Predicts Elevated Levels of Complement 3 Independent of Insulin Resistance and BMI

Vitamin D Insufficiency Predicts Elevated Levels of Complement 3 Independent of Insulin Resistance and BMI

Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

Role of vitamin D in insulin resistance in obese individuals

Contact Info

Product

Resources

About