Serum-25-Hydroxycholecalciferol in Hyperthyroidism

Mosekilde, Leif; Lund, B.; Oh, Sørensen; Ms, Christensen; Melsen, F.

doi:10.1016/s0140-6736(77)92995-6

Cited by 27 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The osteoporosis is characterised by an increased bone resorption with a normal or increased bone formation (Adams et al, 1967). Similar features have recently been reported (Mosekilde et al, 1977) in hyperthyroid bone disease, there being an increase in osteoclastic activity which correlated with the degree of hyperthyroidism, whereas mineralisation activity and bone formation were inversely correlated with thyroid activity.…”

Section: Discussionsupporting

confidence: 87%

“…However, we found that the 25-0HD in hyperthyroidism did not differ from that of the controls. Other workers have found a significant decrease in 25-0HD in hyperthyroidism (Mosekilde et al, 1977;Valentzas et al, 1977) with mean control values of 70 nmoljl compared with our mean control value of 50 nmol/l. In another study (Hunstein et al, 1977), plasma 25-0HD was below the lower limit of normal (25 nmoljl) in 11 of 20 hyperthyroid patients.…”

Section: Discussioncontrasting

confidence: 63%

“…A decrease in the fractional intestinal absorption of calcium occurs (Singhelakis et al, 1974). Although hypercalcaemia in hyperthyroidism is well documented (Rude et al, 1976;Mosekilde et al, 1977) none of our cases showed this. The hypercalcaemia is not due to an excess of parathormone (Christensen, 1976;Rude et al, 1976), and parathormone concentration has been reported as being reduced in normocalcaemic hyperthyroid patients (Bouillon and De Moor, 1974).…”

Section: Discussionmentioning

confidence: 48%

“…Other workers (Mosekilde et al, 1977) found that the free thyroxine index (FT!) correlated with the serum 25-0HD, but that the differences between the 25-0HD values in hyperthyroid patients and in controls was not nearly as great.…”

Section: Hyperthyroid Patients Were Selectedmentioning

confidence: 97%

“…correlated with the serum 25-0HD, but that the differences between the 25-0HD values in hyperthyroid patients and in controls was not nearly as great. These latter workers found a lack of correlation between serum 25-0HD and bone histomorphometry in hyperthyroidism and concluded that the lowered 25-0HD was of minor importance in the development of hyperthyroid bone disease.Hypercalcaemia occurs in at least 8 % of hyperthyroid patients (Baxter and Bondy, 1966), and in one series 51 % (Mosekilde et al, 1977), the serum calcium being positively correlated with the degree of hyperthyroidism and inversely correlated with the serum immunoreactive parathyroid hormone. Because of the variability of the mean plasma 25-0HD and the variable incidence of hypercalcaemia reported in hyperthyroidism, we decided to measure these variables and also the plasma albumin, alkaline phosphatase (AP), AP isoenzymes, alanine transferase (ALT), and y-glutamyl transferase (GGT) in a series of hyperthyroid patients and to compare the results with those obtained from euthyroid patients matched for age, sex, and time of year that blood samples were collected.…”

mentioning

confidence: 93%

See 4 more Smart Citations

Plasma 25-Hydroxyvitamin D and Alkaline Phosphatase Isoenzymes in Hyperthyroidism

Cleeve

Brown

1978

Ann Clin Biochem

View full text Add to dashboard Cite

SUMMARY Plasma 25-hydroxyvitamin D (25-0HD) values in 22 hyperthyroid patients did not differ significantly from those of controls matched for age, sex, and the time of year that plasma samples were taken. In the hyperthyroid group, plasma alkaline phosphatase was significantly higher than in controls, and an increase in bone type alkaline phosphatase occurred in 50 %. In the 18 female hyperthyroid patients the plasma y-glutamyl transferase was significantly increased compared with controls. Mean values for plasma albumin, alanine transferase, and calcium showed no significant difference between hyperthyroid and control patients.Results on the basis of clinical diagnosis supported by an FTI of over 140 (the upper limit of normal for this laboratory). Control patients were those in whom the FTI had been requested by a clinician and were normal. Control patients were matched with hyperthyroid patients for age (± 3 years), sex, and time of year that blood samples were taken (within one month). Patients were excluded from this study if they had received antithyroid therapy before having the blood sample taken or if there was insufficient plasma for all of the analyses to be done. Blood samples were taken over the period July to October 1977.Plasma 25-0HD was measured by a competitive protein binding method (Haddad and Chyu, 1971), modified by the use of diluted human serum as the source of binding protein. Plasma AP isoenzymes were separated by electrophoresis (Cleeve, 1978).Plasma AP, ALT, GGT, FTI, albumin, and calcium were measured by the methods in current use in this laboratory. Calcium values were corrected for the level of plasma albumin (Tomlinson and O'Riordan, 1978). Normal ranges are shown in the Table. There were 18 women and four men in each group, their ages ranging from 19 to 77 years.There were no significant differences in mean plasma 25-0HD, ALT, albumin, and calcium concentrations between the hyperthyroid patients and controls. Two patients in each group had consecutively 25-0HD values below our lower limit of normal. 320Material and methods Hyperthyroid patients were selectedPlasma 25-hydroxyvitamin D (25-0HD) has been reported (Valentzas et al., 1977) to be markedly reduced in hyperthyroidism, and it was, therefore, suggested that it might be an important clue to our understanding of hyperthyroid bone disease. Other workers (Mosekilde et al., 1977) found that the free thyroxine index (FT!) correlated with the serum 25-0HD, but that the differences between the 25-0HD values in hyperthyroid patients and in controls was not nearly as great. These latter workers found a lack of correlation between serum 25-0HD and bone histomorphometry in hyperthyroidism and concluded that the lowered 25-0HD was of minor importance in the development of hyperthyroid bone disease.Hypercalcaemia occurs in at least 8 % of hyperthyroid patients (Baxter and Bondy, 1966), and in one series 51 % (Mosekilde et al., 1977), the serum calcium being positively correlated with the degree of hyperthyroidism and inversely correlat...

show abstract

Section: Discussionsupporting

confidence: 87%