Serum levels of vitamin D metabolites and bone remodelling in hyperthyroidism

Jastrup, B.; Mosekilde, Leif; Melsen, F.; Lund, B; Lund, B.; Sørensen, Ole

doi:10.1016/0026-0495(82)90123-8

Cited by 77 publications

(26 citation statements)

References 21 publications

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“…Several studies have reported a high prevalence of vitamin D deficiency in selected populations including nursing home residents and persons over age 65 [8,9] . There have been few studies, however, of seasonal variations [10][11][12][13][14] in vitamin D levels in Graves' patients.…”

Section: Thyroidectomymentioning

confidence: 99%

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

et al. 2001

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Abstract.We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p <0.001) in female Graves' patients (31.8± 13.3 nmol/1) than in male patients (41.3 ± 15.0 nmol/1). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p<0.005).There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/1 found in 58% of female patients during the winter months. There were significant (p <0.001) differences in serum 25(OH)D levels between age groups in the female patients.The concentrations were lowest in patients in their twenties (25.1 ±8.2 nmol/1) and highest in patients in their fifties and sixties (43.2± 13.7 nmol/1). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.

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Section: Thyroidectomymentioning

confidence: 99%

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

et al. 2001

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“…Furthermore, patients with Cushing's disease were also found to have normal levels of 25(OH)D [381,382]. Similarly, in animal studies, no effect on the conversion of vitamin D to 25(OH)D or 25(OH)D to 1,25(OH) 2 D 3 has been reported [260,383,384].…”

Section: Corticosteroidsmentioning

confidence: 93%

“…In fact, despite normal bone mass and markers of bone turnover, 25(OH)D and 1,25(OH) 2 D levels have been shown to be persistently reduced in euthyroid patients who were 6 years post-treatment of hyperthyroidism [265]. Dietary vitamin D intake and exposure to sunlight may contribute to these differences in 25(OH)D. Circulating levels of 24,25(OH) 2 D 3 are generally increased in hyperthyroid patients [260,261]. Hypothyroidism is associated with decreased bone turnover [266] and low serum calcium levels that activate PTH, which, in turn, enhances 1a-hydroxylase activity [253,259,267].…”

Section: Thyroid Hormonementioning

confidence: 98%

Drug and Hormone Effects on Vitamin D Metabolism

Weinstein¹,

Epstein²

2011

Vitamin D

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“…Prevalence of resorption and osteoid surfaces is increased. However, an increase in the mineral apposition rate and in the fraction of surfaces taking up tetracycline excludes osteomalacia (21,(38)(39)(40).…”

Section: Hyperthyroidismmentioning

confidence: 98%

“…This is accompanied by biochemical evidence for accelerated bone turnover, such as increased urinary excretion of hydroxy proline and serum alkaline phosphatase activity. Slight hypercalcemia may occur, but parathyroid hormone secretion is suppressed (36,37) and serum levels of active vitamin D metabolites are low (38). On biopsy, trabecular bone volume may be low, but is often normal.…”

Section: Hyperthyroidismmentioning

confidence: 98%

Normal and Abnormal Bone Remodeling in Man

Marcus¹

1987

Annu. Rev. Med.

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Remodeling is a continuous process of skeletal destruction and renewal, occurring throughout life in humans and some other mammals. Remodeling minimizes the damage of routine wear but, because of its fundamental inefficiency, also underlies normal age-related bone loss. Alterations in bone mass due to dietary and endocrine factors occur in response to changes in the birthrate of new remodeling units, increased remodeling imbalance within existing units, or a combination of both. Familiarity with remodeling is prerequisite to understanding the pathologic basis and rational therapy of metabolic bone disease.

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Serum levels of vitamin D metabolites and bone remodelling in hyperthyroidism

Cited by 77 publications

References 21 publications

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

Drug and Hormone Effects on Vitamin D Metabolism

Normal and Abnormal Bone Remodeling in Man

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