Serum-25-Hydroxy-Vitamin-D in Untreated Parenchymal and Cholestatic Liver Disease

Metabolic Bone Disease in Alcoholic Cirrhosis: A Comparison of the Effect of Vitamin D225-Hydroxyvitamin D, or Supportive Treatment

“…Similar findings have been reported in other forms of chronic liver disease such as primary biliary cirrhosis (9)(10)(11)(12)(13)(14)(15)(16). In patients with alcoholic cirrhosis, osteoporosis is the predominant form of bone disease and it is usually associated with decreased levels of serum 25-hydroxyvitamin D (25-OH-D) (8,(17)(18)(19). Until a few years ago, defective hydroxylation of vitamin D in the liver was considered to be a possible cause of bone abnormalities in patients with cirrhosis (16,17).…”

“…To compare the efficacy of vitamin Da and 25-OH-D treatment in correcting the metabolic bone disease in alcoholic cirrhosis, the 18 patients were randomized in the following manner, in groups of six patients each: Group 1, control (received no supplemental vitamin D treatment); Group 2, given vitamin Df! (50,000 IU p.0.)…”

Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease.

“…1-4 ± 1 5 04 ± 0-8 Bone pain or fractures 20 17 3 concentration was measured by a modified competitive protein-binding technique (Long et al, 1976) and immunoreactive-parathyroid hormone (i-PTH) by radioimmunoassay (Wills et al, 1974). Two consecutive 24 hour urine collections were assayed for calcium, hydroxyproline and creatinine excretion and the mean of the two results used.…”

Role of hyperbilirubinemia in the impairment of osteoblast proliferation associated with cholestatic jaundice.

“…In Great Britain, a mixture of osteoporosis and osteomalacia commonly occurs due to associated vitamin D deficiency aggravated by steatorrhea. In contrast, in the United States, because of fortification of food with vitamin D, osteoporosis, not osteomalacia, is the major form of the bone disease (3,(6)(7)(8)(9).…”