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Although the presence of eosinophils could be considered a nonspe¬ cific finding, the final interpretation of the liver biopsy specimen was then "severe acute hepatitis, possibly due to drug sensitivi¬ ty."Propranolol and hydrochlorothiazide were substituted for hydralazine. Five days later serum transaminase levels fell toward normal limits. The liver diminished in volume and the patient felt much improved. She was discharged, but readmitted six months later for a control liver biopsy.

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Numerous descriptive and quantitative studies have shown that the jejunal mucosa in coeliac disease is thickened compared with the normal, with fewer, thicker villi, larger crypts, a diminished ratio between the volume of surface epithelium and crypts, a smaller surface area, a reduced surface/volume ratio, and shorter surface cells (Doniach and Shiner, 1957;