Serum γ-glutamyltransferase activity as an indicator of chronic liver injury in cattle with no clinical signs

Moreira, Cecília Nunes; Souza, S. N.; Barini, Angelina; Araújo, Eugênio Gonçalves de; Fíoravantí, Maria Clorínda Soares

doi:10.1590/s0102-09352012000600001

Cited by 19 publications

(20 citation statements)

References 11 publications

(9 reference statements)

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“…The enzymatic changes observed in the blood serum of both groups, particularly of the GGT and GLDH enzymes, confirm liver impairment in animals with foreign body syndrome with or without cardiac involvement. This study confirms the measurement of serum GGT activity in cattle because it has greater specificity in detecting chronic liver injuries (Moreira et al, 2012). The magnitude of GLDH activity observed in animals in both groups confirms liver damage, since this enzyme is considered hepatospecific, being an important indicator of liver necrosis in ruminants (Hoffman & Solter, 2008).…”

Section: Blood Biochemistrysupporting

confidence: 76%

Systemic implications of metallic foreign body syndrome in dairy cattle

Assis

Souza

Soares

et al. 2021

RSD

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This study aimed to evaluate the systemic implications of 37 cattle with traumatic reticulitis, evaluating clinical, laboratory, ultrasonographic and necroscopic changes. A clinical, laboratory and ultrasonographic examination was performed, and the animals were distributed in reticuloperitonitis (GI; n=21) and reticulopericarditis (GII; n=16) traumatic, based on necropsy findings. Blood samples were taken for haematological tests, serum total protein, albumin, globulin, gamma glutamyltransferase (GGT), aspartate aminotransferase (AST), glutamate dehydrogenase (GLDH), creatinine, urea, cortisol, creatine kinase (CK), creatine kinase-MB (CK-MB), cardiac troponin-I (cTn-I), plasma glucose and L-lactate. The abdominocentesis was productive in eight GI (n=8) and seven GII (n=7) animals, allowing the evaluation of physical, cytological and biochemical characteristics of the peritoneal fluid as a total protein, albumin, GLDH, AST, GGT, glucose and L-lactate. Changes in behavior, appetite, dehydration and temperature were observed, most expressive in GII. Hematology showed neutrophilic leukocytosis with regenerative left shift and hyperfibrinogenemia in both groups. Increased globulin, L-lactate concentration and serum GGT, GLDH, CK and CK-MB activity were observed, as well as significant elevation of cTnI (p=0.0190) in GII. In the peritoneal fluid exudate was observed in both groups and a higher concentration of L-lactate in relation to plasma. Ultrasound revealed retocular, cardiac, hepatic and splenic abnormalities. The anatomopathological lesions confirmed the ultrasound findings of both groups. The understanding of the syndrome helps in the diagnosis, as well as the adoption of preventive measures, minimizing the economic impact caused to the dairy cattle breeding.

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Section: Blood Biochemistrysupporting

confidence: 76%

Systemic implications of metallic foreign body syndrome in dairy cattle

Assis

Souza

Soares

et al. 2021

RSD

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“…Biochemical blood indicators, like the activity of some liver enzymes such as aspartate aminotransferase (AST, EC 2.6.1.2) and gamma-glutamyl transferase (GGT, EC 2.3.2.2) in blood serum, are used for the evaluation of metabolic balance [ 7 ]. The hepatic enzymes such as AST and GGT are the two main, sensitive enzymes that primarily reflect hepatocellular necrosis, and cholestasis, respectively, so are proposed to be two of the common parameters for the detection and diagnosis of liver failure [ 8 , 9 ]. The biochemical tests evaluated showed larger specificity than sensitivity regarding the detection of hepatic injuries in healthy dairy cattle.…”

Section: Introductionmentioning

confidence: 99%

Metabolic profile according to the parity and stage of lactation of high-performance Holstein-Friesian cows

et al. 2021

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Objective: The aim of the study was to determine the effect of parity and the stage of lactation on the metabolic profile of cows based on the basic chemical milk components and the blood parameters.Methods: The study material consisted of high-yielding Holstein-Friesian cows. In total, 473 cows were examined. According to the parity, cows were divided into four groups: primiparous (P), and multiparous in the second (M2), in the third (M3), and in subsequent lactations (M4). The feeding of cows was based on total mixed ration (TMR) <i>ad libitum</i>. Milk and blood samples were collected individually from each cow three times per standard lactation period.Results: Greater exacerbation of changes in the dynamics of the blood plasma parameters examined was proved for multiparous cows. The highest value of β-hydroxybutyrate acid (0.946 mmol/L) was found for multiparous cows from group M3 at the beginning of lactation. However, it was still in the normal range. The results showed aspartate aminotransferase, and gamma-glutamyl transferase (GGT) activities in dairy cows during lactation had significant variations taking in to account stage of lactation. The highest activity of GGT was found in the group of the oldest cows and measured from 26.36 U/L at the beginning of lactation to 48.75 U/L at the end of the lactation period.Conclusion: The time-related changes in the concentrations of the biochemical parameters described differ markedly among lactating cows, though the housing conditions on the research dairy farm are highly standardised. This indicates that the ability to cope with metabolic stress is mainly affected by the individual predispositions of cows and feed nutrient supply in different stage of lactation. Especially, the feed nutrient supply (in net energy for lactation), which was the best in TMR 1 in comparison TMR 3.

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“…Regarding the hepatic status, clinical biochemistry may correspond to a change, but it does not reveal the causes, types, or the distribution of the injury. Thus, histopathological analysis is essential to obtain consistent information about the hepatic histopathology (Moreira et al, 2012). In this context, results of AST and ALT corroborate the mild changes observed in the group treated with dry leaf extract (DL).…”

Section: Biochemical Analyses Of Alt and Astmentioning

confidence: 63%

Acetylcholinesterase inhibitory potential and lack of toxicity of Psychotria carthagenensis infusions

Nascimento

Rivero-Wendt

Miranda-Vilela

et al. 2021

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We aimed to evaluate the phytochemical composition of the aqueous extract of leaves of Psychotria carthagenensis, and its possible toxicological effects at 200 µg/Kg on Rattus norvegicus. The aqueous extract was used for preliminary phytochemical analyses using standard procedures. After, male albino Wistar rats (N= 6/group) received by gavage for 15 consecutive days, infusions with fresh (FL) and dry leaf (DL) at 200 µg/kg; controls received filtered water (negative) or clonazepam solution at 0.5 mg/kg (positive). Hematological analyses, determination of serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, uric acid, total plasma protein (TPP), quantification of serum cholinesterase (AChE), and histological analyses of kidneys and liver were carried out. By the phytochemical analysis of the aqueous leaf extract, it was possible to detect the total phenols, flavonoids, tannins and alkaloids, the latter having been recorded for the species for the first time in this study. ALT and AST levels indicated an increase in these plasma enzymes, but histological analysis of kidneys and liver showed only slight changes. Inhibition of AChE levels was related mainly to alkaloids. The infusion showed the pharmacological potential of the plant as an alternative in the treatment of neurodegenerative diseases.

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Serum γ-glutamyltransferase activity as an indicator of chronic liver injury in cattle with no clinical signs

Cited by 19 publications

References 11 publications

Systemic implications of metallic foreign body syndrome in dairy cattle

Systemic implications of metallic foreign body syndrome in dairy cattle

Metabolic profile according to the parity and stage of lactation of high-performance Holstein-Friesian cows

Acetylcholinesterase inhibitory potential and lack of toxicity of Psychotria carthagenensis infusions

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