Sertraline versus other antidepressive agents for depression

Cipriani, Andrea; Ferla, T. La; Furukawa, Toshi A; Signoretti, Alessandra; Nakagawa, Atsuo; Churchill, Rachel; McGuire, Hugh; Barbui, Corrado

doi:10.1002/14651858.cd006117.pub3

Cited by 57 publications

(57 citation statements)

References 101 publications

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“…When quetiapine was used as an adjunct to unsuccessful antidepressant treatment, the corresponding numbers needed to treat or harm were estimated to be 10, 8 and 12, respectively. The only direct comparison with an antidepressant was with duloxetine, which may be less effective and less tolerable than other antidepressants; 22 that study found no differences in efficacy between treatment and control groups, but overall tolerability was reduced among those taking quetiapine. 23 The extent of quetiapine use to treat anxiety is unprecedented for an antipsychotic.…”

Section: Discussionmentioning

confidence: 97%

Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study

Pringsheim

Gardner

2014

CMAJ Open

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Section: Discussionmentioning

confidence: 97%

Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study

Pringsheim

Gardner

2014

CMAJ Open

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“…This checklist was completed for each patient eight weeks after the beginning of the study intervention. The presence of each side effect was documented by placing a checkmark in front of it in the checklist (8). The data on depression severity and response to treatment were collected at four time points, namely before, two, four, and eight weeks after the beginning of the intervention.…”

Section: Sertraline Side Effect Checklistmentioning

confidence: 99%

“…Thereby, given the high prevalence of MDD and MDDinduced disability, MDD annually causes billions of dollars of economic damage worldwide (7). It also aggravates illnesses such as asthma, diabetes mellitus, and arthritis (8). More seriously, MDD is associated with a high prevalence of suicidal and even homicidal thoughts (6,9).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the most important medications for MDD management are tricyclic antidepressants, monoamine oxidase inhibitors, and serotonin reuptake inhibitors (16,17). As one of the inhibitors of serotonin reuptake, sertraline is the best treatment option for the improvement of MDD symptoms (8). Recently, depression symptoms were found to have a reciprocal relationship with inflammation (18).…”

Section: Introductionmentioning

confidence: 99%

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The effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder: A randomized clinical trial

Sepehrmanesh¹,

Fahimi²,

Akasheh³

et al. 2017

Electron Physician

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Background: Different studies have been conducted to find the best adjuvant therapies for depression management. There are controversies over the effects of aspirin as an adjuvant therapy for depression. Objective: To determine the effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder. Methods: This randomized clinical trial was conducted at Kargarnejad Psychiatric Hospital in Kashan, Isfahan, Iran, from September 1, 2016 to November 1, 2016. The study participants included 100 patients with major depressive disorder who were assigned to aspirin and placebo groups by the use of computer-generated random numbers. Patients in these groups respectively received sertraline-aspirin and sertraline-placebo for eight consecutive weeks. Patients were prescribed 80 milligrams of aspirin twice a day. Also, sertraline was administered at a dose of 50-200 milligrams daily. Beck Depression Inventory was employed for depression severity assessment at four time points, namely before, two, four, and eight weeks after the beginning of the intervention. Medication side effects were also assessed eight weeks after the beginning of the intervention. Data were analyzed by SPSS version 12.0, using Chi-square and the Independent-samples t-test (α=0.05). Results: Both groups were matched in terms of age (p=0.46), gender (p=0.539), and depression severity (p=0.509, with mean score 33.5±4.1 vs. 32.8±5.9) at baseline. However, depression scores were reduced significantly four and eight weeks after initiation of therapy just in the sertraline-aspirin group (p<0.05). Conclusion:As an adjuvant therapy, aspirin can reduce depression severity among patients with major depressive disorder. Yet, further studies are needed to prove the effectiveness of aspirin and other antiinflammatory agents in reducing depression severity.

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“…• Escitalopram, 6 venlafaxine, 7 and sertraline 8 have each been shown to be superior to all others; this puts conclusions of each into question.…”

mentioning

confidence: 99%

Second-Generation Antidepressants

Allan

Virani²,

Ivers³

2013

Encyclopedia of Pain

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In adults suffering from depression, are some secondgeneration antidepressants more effective than others? Evidence• A 2008 systematic review 1 compared benefits and harms of second-generation antidepressants.-No important difference in effectiveness. The few statistical differences found were not clinically important (eg, escitalopram 1.13 points better than citalopram on the 60-point MADRS scale [minimal clinically important difference ≥ 2]); sponsorship might have played a role in these subtle differences. -Adverse events: similar amount (61% of patients had ≥ 1), but types vary.• A 2009 systematic review 2 examined response to treatment and withdrawal, and identified some small differences in efficacy and acceptability. -Efficacy top 4: mirtazapine, escitalopram, venlafaxine, and sertraline. -Acceptability top 4: escitalopram, sertraline, bupropion, and citalopram.• Both reviews had validity concerns, like the use of indirect comparisons, but the 2009 review had additional issues with treating all depression scales as the same (and they are not), and using odds ratios that could exaggerate differences. Context• Considerable bias exists in antidepressant evidence: Few studies are high quality 1,3 and positive trials are selectively published 4,5 (and republished 5 ) while more than 60% of negative trials are never published. 4• Industry-sponsored trials favour their products (about 5%) over any other antidepressants. 3• Escitalopram, 6 venlafaxine, 7 and sertraline 8 have each been shown to be superior to all others; this puts conclusions of each into question.• A trial comparing bupropion, venlafaxine, and sertraline as second-line therapy found no difference. 9• On average, 54% of patients taking antidepressants and 37% of those given placebos get a 50% reduction in symptoms in 8 to 12 weeks. 10 Bottom lineAmong second-generation antidepressants, there is little or no reliable difference in effectiveness. The frequency of adverse events is also similar, but the types of adverse events do vary. ImplementationRegular assessment of depression and response to therapy is an important part of management. Standardized scales, such as the PHQ-9, can help providers monitor progress and determine treatment.11 Results should be discussed with patients and used to supplement clinical decision making. 12,13 For information about the PHQ-9 and for a copy of the scale itself, visit the MacArthur Initiative on Depression and Primary Care website (www.depression-primarycare.org). and doctors' views on depression severity questionnaires incentivised in UK quality and outcomes framework: qualitative study.

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Sertraline versus other antidepressive agents for depression

Cited by 57 publications

References 101 publications

Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study

Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study

The effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder: A randomized clinical trial

Second-Generation Antidepressants

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