Dispensed prescriptions for quetiapine and other second-generation antipsychotics in Canada from 2005 to 2012: a descriptive study

Atypical antipsychotics for insomnia: a systematic review

“…Atypical antipsychotics are effective for schizophrenia and bipolar disorder (1)(2)(3). Sedating properties of certain atypical antipsychotics such as quetiapine have led to their off label use for insomnia (1,4).…”

Time trends in intracranial bleeding associated with direct oral anticoagulants: a 5-year cohort study

“…The data have been used previously to evaluate prescribing trends. [10][11][12] We requested further information on data collection; however, IMS Brogan does not release details regarding which pharmacies contribute to their database. Data for the same period were available from both sources and were compared to evaluate consistency of the findings.…”

AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis

“…While second-generation antipsychotic (SGA) drugs have traditionally been used as a front line treatment for schizophrenia, there has been a drastic increase in off-label use over the past decade (Pringsheim and Gardner, 2014). SGAs have been increasingly prescribed for offlabel conditions such as anxiety, attention deficit hyperactivity disorder (ADHD), insomnia and chemotherapy-induced nausea (Maher et al, 2011;Pringsheim and Gardner, 2014;Devlin and Panagiotopoulos, 2015;Bun et al, 2017;Chelkeba et al, 2017).…”

“…SGAs have been increasingly prescribed for offlabel conditions such as anxiety, attention deficit hyperactivity disorder (ADHD), insomnia and chemotherapy-induced nausea (Maher et al, 2011;Pringsheim and Gardner, 2014;Devlin and Panagiotopoulos, 2015;Bun et al, 2017;Chelkeba et al, 2017). SGAs, such as olanzapine (OLZ), have numerous metabolic side effects (Newcomer, 2005).…”