Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients

Atalay, Hüseyin; Solak, Yalçın; Bıyık, Murat; Bıyık, Zeynep; Yeksan, Mehdi; Uğuz, Faruk; Güney, İ̇brahim; Tonbul, Halil Zeki; Türk, Süleyman

doi:10.1007/s11255-009-9686-y

Cited by 40 publications

(40 citation statements)

References 34 publications

(46 reference statements)

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“…In a pilot trial, Koudi et al showed that aerobic exercise improved symptoms of depression(30), while a randomized trial of 96 patients on hemodialysis showed no significant benefit of exercise training on depression scores at one year(31). Treatments for depression in ESRD include antidepressants(32–35) and cognitive behavioral therapy (CBT)(36). Recently, Duarte et al .…”

Section: Discussionmentioning

confidence: 99%

Effects of 6-Times-Weekly Versus 3-Times-Weekly Hemodialysis on Depressive Symptoms and Self-reported Mental Health: Frequent Hemodialysis Network (FHN) Trials

Unruh

Larive

Chertow

et al. 2013

American Journal of Kidney Diseases

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Background Patients undergoing maintenance hemodialysis frequently exhibit poor mental health. We studied the effects of frequent in-center and nocturnal hemodialysis on depressive symptoms and self-reported mental health. Study Design 1-year randomized-controlled clinical trials. Setting & Participants Hemodialysis centers in the United States and Canada. A total of 332 patients were randomized to frequent (six times per week) as compared with conventional (three times per week) hemodialysis in the Frequent Hemodialysis Network (FHN) Daily (n=245) and Nocturnal (n=87) Trials. Intervention Daily Trial was a trial of frequent (six times per week), as compared with conventional (three times per week) in-center hemodialysis. The Nocturnal Trial assigned patients to either frequent nocturnal hemodialysis (six times per week) or conventional hemodialysis (three times per week). Outcomes Self-reported depressive symptoms and mental health. Measurements Beck Depression Inventory (BDI) and the mental health composite (MHC) score and emotional subscale of the RAND 36-Item Health Survey at baseline, 4 and 12 months. The MHC score is derived by summarizing these domains of the RAND 36-Item Health Survey: emotional, role emotional, energy/fatigue, and social functioning scales. Results In the Daily Trial, subjects randomized to frequent as compared with conventional in-center hemodialysis demonstrated no significant change over 12 months in adjusted mean BDI (−1.9 ± 0.7 vs. −0.6 ± 0.7; p=0.2), but experienced clinically significant improvements in adjusted mean MHC (3.7 ± 0.9 vs. 0.2 ± 1.0; P<0.01) and the emotional subscale (5.2 ± 1.6 vs. −0.3 ± 1.7; p=0.01). In the Nocturnal Trial, there were no significant changes among subjects randomized to nocturnal as compared with conventional hemodialysis on the same metrics. Limitations The trial interventions were not blinded. Conclusions Frequent in-center hemodialysis, as compared with conventional in-center hemodialysis, improved self-reported general mental health. Changes in self-reported depressive symptoms were not statistically significant. We were unable to conclude whether nocturnal hemodialysis yielded similar effects.

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Section: Discussionmentioning

confidence: 99%

Effects of 6-Times-Weekly Versus 3-Times-Weekly Hemodialysis on Depressive Symptoms and Self-reported Mental Health: Frequent Hemodialysis Network (FHN) Trials

Unruh

Larive

Chertow

et al. 2013

American Journal of Kidney Diseases

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“…In 60 (18.8%) of these patients, clinical depression was diagnosed. 19 In addition, Atalay et al 20 indicated that 32 of 124 CAPD patients (25.8%) had depression based on BDI. Similarly, in our study, 10 (25%) of 40 patients had depression disorder.…”

Section: Discussionmentioning

confidence: 99%

Association between Depression, Nutritional Status, and Inflammatory Markers in Peritoneal Dialysis Patients

et al. 2012

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“…Paroxetine, combined with supportive psychotherapy, has been shown to be not only successful for treating depression, but also for improving nutritional status in chronic HD patients with depression (Koo et al, 2005). Sertraline has safe pharmacokinetics in patients with ESRD, and treatment with sertraline in PD patients is associated with improved of QoL and fewer symptoms of depression (Atalay et al, 2010). Duloxetine and venlafaxine, which are categorized as serotonin-norepinephrine reuptake inhibitors, are beneficial for patients with major depressive disorder (Ye et al, 2011).…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

The Psychological Impact of Hemodialysis on Patients with Chronic Renal Failure

Wang¹,

Chen²

2012

Renal Failure - The Facts

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Sertraline treatment is associated with an improvement in depression and health-related quality of life in chronic peritoneal dialysis patients

Abstract: Treatment of depression with sertraline is associated with improvement of the HRQoL and symptoms related to depression.

Cited by 40 publications

References 34 publications

Effects of 6-Times-Weekly Versus 3-Times-Weekly Hemodialysis on Depressive Symptoms and Self-reported Mental Health: Frequent Hemodialysis Network (FHN) Trials

Effects of 6-Times-Weekly Versus 3-Times-Weekly Hemodialysis on Depressive Symptoms and Self-reported Mental Health: Frequent Hemodialysis Network (FHN) Trials

Association between Depression, Nutritional Status, and Inflammatory Markers in Peritoneal Dialysis Patients

The Psychological Impact of Hemodialysis on Patients with Chronic Renal Failure

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