Sertraline safety and efficacy in major depression: A double-blind fixed-dose comparison with placebo

Fabre, Louis F.; Abuzzahab, F. S.; Amin, Muhammad; Claghorn, James L.; Mendels, J.; Petrie, William M.; Dubé, Sanjay; Small, Joyce G.

doi:10.1016/0006-3223(95)00178-8

Cited by 157 publications

(108 citation statements)

References 11 publications

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“…All of these 10 trials were captured by our search method and are included in online supplementary Table 3 (references [27,28,29,30,31]) and in online supplementary Table 6 (references [32,33,34,35,36]). In accordance with the overall conclusion of this systematic review, these 10 studies also demonstrated superior responsiveness of HAM-D 6 compared to that of HAM-D 17 and MADRS.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Clinimetric Properties of the 6-Item Version of the Hamilton Depression Rating Scale (HAM-D<sub>6</sub>)

Timmerby

Andersen

Søndergaard

et al. 2017

Psychother Psychosom

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Background: In a study aimed at identifying the items carrying information regarding the global severity of depression, the 6-item Hamilton Depression Rating Scale (HAM-D₆) was derived from the original 17-item version of the scale (HAM-D₁₇). Since then, the HAM-D₆ has been used in a wide range of clinical studies. We now provide a systematic review of the clinimetric properties of HAM-D₆ in comparison with those of HAM-D₁₇ and the Montgomery Asberg Depression Rating Scale (MADRS). Methods: We conducted a systematic search of the literature in PubMed, PsycInfo, and EMBASE databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline. Studies reporting data on the clinimetric validity of the HAM-D₆ and either the HAM-D₁₇ or MADRS in non-psychotic unipolar or bipolar depression were included in the synthesis. Results: The search identified 681 unique records, of which 51 articles met the inclusion criteria. According to the published literature, HAM-D₆ has proven to be superior to both HAM-D₁₇ and MADRS in terms of scalability (each item contains unique information regarding syndrome severity), transferability (scalability is constant over time and irrespective of sex, age, and depressive subtypes), and responsiveness (sensitivity to change in severity during treatment). Conclusions: According to the published literature, the clinimetric properties of HAM-D₆ are superior to those of both the HAM-D₁₇ and MADRS. Since the validity of HAM-D₆ has been demonstrated in both research and clinical practice, using the scale more consistently would facilitate translation of results from one setting to the other.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Clinimetric Properties of the 6-Item Version of the Hamilton Depression Rating Scale (HAM-D<sub>6</sub>)

Timmerby

Andersen

Søndergaard

et al. 2017

Psychother Psychosom

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“…The exclusion from the study of patients with primary affective illness or anxiety disorder diagnoses may have reduced the incidence of comorbid affective illness in the current sample compared with what has been reported in the community. 1 A potential therapeutic advantage of sertraline as a treatment for PTSD is its established efficacy in treating disorders commonly comorbid with PTSD, such as depression [31][32][33] and panic disorder. [34][35][36] In the current study, sertraline demonstrated a significant efficacy advantage over placebo in the treatment of PTSD (Table 3), although specific measures of panic or anxiety disorders were not obtained.…”

Section: Commentmentioning

confidence: 99%

Efficacy and Safety of Sertraline Treatment of Posttraumatic Stress Disorder

Brady

Pearlstein²,

Asnis³

et al. 2000

JAMA

616

362

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RAUMATIC STRESS IS A SIGNIFIcant public health problem 1 that frequently results in a distinctive pattern of persistent and disabling psychological and physiological symptoms. 2,3 Once thought to be primarily limited to soldiers in combat, posttraumatic stress disorder (PTSD) is now recognized in civilians, including those who have experienced natural disasters, physical and sexual assault, fire, motor vehicle and other serious trauma, as well as those who have witnessed inflicted injury or death. Exposure to a traumatic event is common, estimated in the range of 5% to 35% annually, with a lifetime exposure to 1 or more traumatic events occurring in more than 50% of the US population. 1 The clinical presentation of PTSD is characterized by moderate-to-severe symptoms in 3 separate domains: reexperiencing (intrusive thoughts, nightmares, flashbacks, images, or memories), emotional numbing and avoidance (flattened affect or detachment, loss of interest and motivation, and avoidance of any activity, place, person, or topic associated with the trauma); and Author Affiliations and Financial Disclosures are listed at the end of this article.

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“…Bupropion hydrochloride sustained release (SR) and sertraline have demonstrated antidepressant efficacy in randomized, double-blind, placebo-controlled studies in outpatients with major depressive disorder (Reimherr et al 1990(Reimherr et al , 1998Fabre et al 1995;Croft et al 1999;Coleman et al 1999). Bupropion has demonstrated comparable antidepressant efficacy to sertraline (Kavoussi et al 1997;Croft et al 1999;Coleman et al 1999), fluoxetine (Feighner et al 1991), and paroxetine (Weihs et al 2000) in outpatients with major depressive disorder.…”

mentioning

confidence: 99%

Response in Relation to Baseline Anxiety Levels in Major Depressive Disorder Treated with Bupropion Sustained Release or Sertraline

Rush

2001

Neuropsychopharmacology

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Sertraline safety and efficacy in major depression: A double-blind fixed-dose comparison with placebo

Cited by 157 publications

References 11 publications

A Systematic Review of the Clinimetric Properties of the 6-Item Version of the Hamilton Depression Rating Scale (HAM-D<sub>6</sub>)

A Systematic Review of the Clinimetric Properties of the 6-Item Version of the Hamilton Depression Rating Scale (HAM-D<sub>6</sub>)

Efficacy and Safety of Sertraline Treatment of Posttraumatic Stress Disorder

Response in Relation to Baseline Anxiety Levels in Major Depressive Disorder Treated with Bupropion Sustained Release or Sertraline

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