Sertraline-Induced Enuresis in a Prepubertal Child Resolves after Switching to Fluoxetine

Maalouf, Fadi T.; Gilbert, Anna C.

doi:10.1089/cap.2009.0031

Cited by 6 publications

(8 citation statements)

References 18 publications

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“…4 Conversely, and quite interestingly, several cases have been reported of enuresis improving with SSRI administration or by switching to a different SSRI, including a change from sertraline to fluoxetine. 5 Fluoxetine exerts some dopaminergic effect, which has been previously linked to increased continence. 6,7 It has even been demonstrated as a potentially safe and effective therapy for monosymptomatic nocturnal enuresis in children.…”

Section: Discussionmentioning

confidence: 99%

“…4 It also produces an inhibition of dopamine release and an increase in the release of endogenous opioids. 5 Excessive daytime sleepiness in narcolepsy is usually treated with wakefulnesspromoting agents such as methylphenidate, dextroamphetamine, and modafinil in addition to behavioral interventions 6 as firstline treatment. In those who experience unacceptable adverse effects or an inadequate response to wakefulness-promoting treat-ment, SO may be effective when administered in 2 equivalent doses in the evening, spaced from 2.5 to 4 hours, with a recommended starting dose of 4.5 g/d.…”

Section: Mania-like Reaction Secondary To Sodium Oxybatementioning

confidence: 99%

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Fluoxetine-Associated Enuresis in a Pediatric Patient

Horgan,

Charatcharungkiat

2024

J Clin Psychopharmacol

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Section: Discussionmentioning

confidence: 99%

Section: Mania-like Reaction Secondary To Sodium Oxybatementioning

confidence: 99%

Fluoxetine-Associated Enuresis in a Pediatric Patient

Horgan,

Charatcharungkiat

2024

J Clin Psychopharmacol

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“…The lower urinary tract is influenced by various neurotransmitter pathways. In literature, there have been several case reports of urinary incontinence associated with the use of selective serotonin reuptake inhibitor (SSRI) antidepressants [ 24 ] and antipsychotics over a broad range of doses [ 25 ]. In terms of biological mechanisms, SSRIs may have agonist effects on 5-HT4 receptors, which are also found in the urinary tract and could evoke responses in the bladder and urethra [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Obsessive-Compulsive Disorders and Functional Urinary Disorders: A Fortuitous Association?

Lim

Loke

et al. 2021

Behavioral Sciences

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Although psychological factors are known to affect bladder and bowel control, the occurrence of functional urinary disorders in patients with psychiatric disorders has not been well-studied or described. A higher prevalence of functional lower urinary tract disorders have also been reported amongst patients with obsessive-compulsive (OC) disorders. A systematic literature search of PubMed, EMBASE, OVID Medline, PsycINFO, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group (CCDANTR), Clinicaltrials.gov and Google Scholar databases found five observational studies on the topic. Unfortunately, as only one study had a (healthy) control group, a meta-analytic approach was not possible. Overall, patients with OC symptoms appeared to have increased occurrence of functional urinary symptoms, e.g., overactive bladder, increase in urgency, frequency, incontinence and enuresis. This was even more common amongst patients with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections (PANDAS) or Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) as opposed to patients with OCD alone. Several biological and behavioural mechanisms and treatment approaches were discussed. However, as the current evidence base was significantly limited and had moderate to serious risk of bias, no strong inferences could be drawn. Further well-designed cohort studies are necessary to better elucidate the observed associations and their management.

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“…Human bladder muscles have three different serotonin (5-HT) receptor sites, 5HT-4, 5HT-7 and 5HT1A. 5HT-4 and 5HT-7 are excitatory receptors for acetylcholine which is suggested to be related with dose-dependent effects of sertraline in nocturnal enuresis 7,8 . 5HT-4 agonists like cisapride are known to increase the urination frequency, and SSRIs may have a similar effect.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, Kiatichi et al have reported the increase of dopamine in the nucleus accumbens and striatum of rats caused by sertraline 17 . Secondly, sertraline and venlafaxine may both increase the urination frequency, which may be another reason for nocturnal enuresis 12,8 .…”

Section: Discussionmentioning

confidence: 99%