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S elective serotonin reuptake inhibitors (SSRIs) are the mainstay of pharmacological treatment in various psychiatric disorders in both younger individuals and adults and are considered to be a first-line treatment alongside cognitive behavioral therapy (CBT) in patients with depressive disorder, anxiety disorders, and obsessive-compulsive disorder (OCD) with moderate or severe functional deficit. 1 Its primary known mechanism is to specifically inhibit reuptake of serotonin (5-HT) by 5-HT transporter at the synaptic cleft, resulting in high 5-HT concentration at the postsynaptic membrane, exerting serotoninergic effect. 2 With higher specificity of SSRIs compared with other groups of antidepressants (ie, tricyclic antidepressant and monoamine oxidase inhibitors), SSRIs are associated with less anticholinergic and adrenergic side effects. 3 For OCD, SSRIs tend to exhibit their highest efficacy in the upper range of tested doses, potentially contributing to a higher incidence of side effects. 4 Commonly reported side effects of SSRIs include nausea, vomiting, sleep disturbance, headache, and decreased libido. Less common ones that generally warrant medical attention are extrapyramidal symptoms, serotonin syndromes, and suicidality. 3 Urinary incontinence (UI) has been reported as a rare and overlooked side effect of SSRIs. Its incidence is very low. 5 Literature in children and adolescents is even more scarce, with only a few published case reports of SSRI-associated urinary side effects. [6][7][8] Nonetheless, it can be devastating to the patients, hindering their quality of life. 9 It can also tamper with patient's therapeutic alliance with clinicians and pose challenges to treatment. 4 This case report and literature review will add to the scant pool of evidence of SSRI-associated UI in a teenager. It also
S elective serotonin reuptake inhibitors (SSRIs) are the mainstay of pharmacological treatment in various psychiatric disorders in both younger individuals and adults and are considered to be a first-line treatment alongside cognitive behavioral therapy (CBT) in patients with depressive disorder, anxiety disorders, and obsessive-compulsive disorder (OCD) with moderate or severe functional deficit. 1 Its primary known mechanism is to specifically inhibit reuptake of serotonin (5-HT) by 5-HT transporter at the synaptic cleft, resulting in high 5-HT concentration at the postsynaptic membrane, exerting serotoninergic effect. 2 With higher specificity of SSRIs compared with other groups of antidepressants (ie, tricyclic antidepressant and monoamine oxidase inhibitors), SSRIs are associated with less anticholinergic and adrenergic side effects. 3 For OCD, SSRIs tend to exhibit their highest efficacy in the upper range of tested doses, potentially contributing to a higher incidence of side effects. 4 Commonly reported side effects of SSRIs include nausea, vomiting, sleep disturbance, headache, and decreased libido. Less common ones that generally warrant medical attention are extrapyramidal symptoms, serotonin syndromes, and suicidality. 3 Urinary incontinence (UI) has been reported as a rare and overlooked side effect of SSRIs. Its incidence is very low. 5 Literature in children and adolescents is even more scarce, with only a few published case reports of SSRI-associated urinary side effects. [6][7][8] Nonetheless, it can be devastating to the patients, hindering their quality of life. 9 It can also tamper with patient's therapeutic alliance with clinicians and pose challenges to treatment. 4 This case report and literature review will add to the scant pool of evidence of SSRI-associated UI in a teenager. It also
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