SERS based Y-shaped aptasensor for early diagnosis of acute kidney injury

Abstract

We develop a promising SERS-based aptasensor for duplex detection of protein biomarkers in AKI. The development of biomarker specific sensors is of great significance to achieving accurate diagnosis and monitoring the occurrence and progress of AKI.

Development and future of droplet microfluidics

“…Monodisperse microparticles can be fabricated through solidification of the entire droplets. 55,56 Chemical polymerization is a common method to solidify the droplets and has been applied to a variety of materials, including gelatin methacrylate (GelMA) 57 and poly(ethylene glycol) diacrylate (PEGDA). 58 Upon ultraviolet (UV) irradiation, heating, or redox reaction, covalent linkages can be formed within the matrices to solidify the droplets.…”

Bioinspired bioassay platforms derived from colloidal crystals with topological shapes

“…[89][90][91][92][93][94][95][96][97][98][99][100] Therefore, it can be used as a reliable method to generate droplets or fibers with tunable and uniform sizes. [62,[101][102][103][104][105][106][107][108] For example, Zhang et al designed a microfluidic chip whose inner and outer phases were the colloidal suspension and silicon oil, respectively. [109] The oil cut the colloidal suspension into droplets, which were then collected in silicon oil for drying.…”

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

“…[ 14 ] To date, the rapid development of nanotechnology and increasing clinical demands have given rise to the emerging interdisciplinary field of nanomedicine, bringing about a profound paradigm shift. [ 15 ] Over the past few decades, a large number of nanomaterials used for disease diagnosis and/or treatment have been proposed, and the advantages of nanomaterials have gradually emerged: I) the ultra‐small size of nanomaterials provides a large surface area and more reaction sites; [ 16 ] II) the physical and chemical properties of nanomaterials (e.g., optical, magnetic, mechanical, and electrical properties) can be regulated by the controllable composition and structure of the nanomaterials; [ 17 ] III) the size of nanomaterials is much smaller than that of cells, which makes them easily penetrate through various biological barriers and have favorable biocompatibility; [ 18 ] IV) the enhanced permeability and retention (EPR) effect promotes passive targeting accumulation of nanomaterials in tumors or other pathological sites; [ 19 ] V) the off‐target effect of nanomaterials can be significantly reduced by modifying the active targeting ligand. [ 20 ] These characteristics endow nanomaterials with potential value for clinical application.…”