SERS based sandwich immunosensing with plasmonically active plastic optical fiber sensor probes

Christopher, Christina; Vasanthakumari, Priyanka; Asaithambi, Gowri; Subrahmanyam, A.; Sai, V. V. R.

doi:10.1364/sensors.2016.sew3e.7

Cited by 2 publications

(2 citation statements)

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“…Thus, the AuNP antibody Raman label conjugates not only improve the signal‐to‐noise ratio but also specificity of the biomolecular detection. A sandwich immunoassay with AuNP labels was performed as described in our previous work . Briefly, the amine functionalized probe was saturated with 40 nm gold nanoparticles.…”

Section: Sers Activity Of Plasmonic U‐bent Pof Probesmentioning

confidence: 99%

“…In case of conventional solid core fibers, plasmonic nanostructures are generated on either the fiber distal end or the fiber core surface to excite them passively or exploit evanescent wave‐based excitation, respectively . In comparison to distal end configuration, the fiber probes with geometric modifications such as D shaped, tapered, or U bent fabricated by inexpensive means have been shown to efficiently excite the plasmonic nanostructures over large modified surface simultaneously by virtue of evanescent waves. Amongst the above fiber modifications, U‐bent probes offer several advantages including (a) ergonomical dip‐type design without risk of breakage at the tip, unlike tapered probes, (b) availability of larger area on fiber for plasmonic nanostructures in comparison to conventional SERS probes, and (c) compatibility with fabrication processes such as nanoparticle chemisorption, microfabrication processes, and recent advances such as nanosphere lithography and nano‐skiving …”

Section: Introductionmentioning

confidence: 99%

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Development of plasmonic U‐bent plastic optical fiber probes for surface enhanced Raman scattering based biosensing

Danny

Subrahmanyam

Sai

2018

J Raman Spectroscopy

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Evanescent wave-based excitation of noble metal nanostructures on fiber core surface allows simultaneous excitation over a larger area in comparison with free space coupling, and hence highly suitable for development of surfaceenhanced Raman scattering (SERS)-based sensor applications. This study describes the development of plasmonically active U-bent plastic optical fiber (POF) probes for SERS-based sensing. The SERS activity of gold nanostructures on the fiber probe surface obtained by means of electroless deposition, sputtering, and chemisorption of nanoparticles are thoroughly characterized using a confocal microscopic setup. Influence of excitation wavelength and laser excitation power on SERS activity and stability of the plasmonic U-bent probes is evaluated. Gold-sputtered POF probes and gold nanoparticle immobilized POF probes show higher enhancement factor in the order tõ 10 8 . A biosensor application of these POF-based SERS sensors is demonstrated by realizing a sandwich immunoassay with 4-MBA as Raman label. KEYWORDS biosensor, fiber optic SERS, plastic optical fiber, SERS sandwich immunoassay, U-bent fiber optic sensor

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Section: Sers Activity Of Plasmonic U‐bent Pof Probesmentioning

confidence: 99%