Development of plasmonic U‐bent plastic optical fiber probes for surface enhanced Raman scattering based biosensing

Abstract

Evanescent wave-based excitation of noble metal nanostructures on fiber core surface allows simultaneous excitation over a larger area in comparison with free space coupling, and hence highly suitable for development of surfaceenhanced Raman scattering (SERS)-based sensor applications. This study describes the development of plasmonically active U-bent plastic optical fiber (POF) probes for SERS-based sensing. The SERS activity of gold nanostructures on the fiber probe surface obtained by means of electroless deposition, sputtering, and chemisorption of nanoparticles are thoroughly characterized using a confocal microscopic setup. Influence of excitation wavelength and laser excitation power on SERS activity and stability of the plasmonic U-bent probes is evaluated. Gold-sputtered POF probes and gold nanoparticle immobilized POF probes show higher enhancement factor in the order tõ 10 8 . A biosensor application of these POF-based SERS sensors is demonstrated by realizing a sandwich immunoassay with 4-MBA as Raman label. KEYWORDS biosensor, fiber optic SERS, plastic optical fiber, SERS sandwich immunoassay, U-bent fiber optic sensor

Preparation and Application of Metal Nanoparticals Elaborated Fiber Sensors

“…Before that, the silica surface of optical fiber needs to be silanized or amino-modified [ 39 ]. Furthermore, Ag NPs were loaded with other types of metal NPs to obtain better sensing properties [ 40 ]. For PCFs with special structures, the SPR film was prepared when the solution of Au NPs flows slowly through the inner wall of the modified hollow core, as shown in Figure 3 d. The NPs density depends on the volume ratio of bonded and unbound silanes [ 41 ].…”

Recent advances in linear and nonlinear Raman spectroscopy. Part XIII

“…Danny and co‐workers reported the development of plasmonic U‐bent plastic optical fibre probes for SERS‐based biosensing. The SERS activity of the gold nanostructures on the fibre probe surface was obtained by means of electroless deposition, sputtering, and chemisorption of NPs and were thoroughly characterized by using a confocal microscopic setup . Dhafer et al carried out a SERS study of polyproline/Ag nanocomposite developed to prevent postsurgery infection.…”

“…The SERS activity of the gold nanostructures on the fibre probe surface was obtained by means of electroless deposition, sputtering, and chemisorption of NPs and were thoroughly characterized by using a confocal microscopic setup. [35] Dhafer et al carried out a SERS study of polyproline/Ag nanocomposite developed to prevent postsurgery infection. Antibacterial performances of polyproline/Ag nanocomposite against gram-positive and gram-negative colonies of bacteria were also investigated.…”

Self‐Assembled Polyamidoamine Dendrimer on Poly (methyl meth‐ acrylate) for Plasmonic Fiber Optic Sensors

“…Recently, POF has been exploited in development of plasmonic fiber optic sensors (P‐FOS) based on surface plasmon resonance (SPR) and localized SPR (LSPR) . Noble metal nanostructures were deposited on a POF surface by means of either sputter deposition or chemisorption of nanoparticles from solution phase . Sputter deposition on PMMA based POF is associated with formation of craters due to evaporation of water content, leading to surface deformation and inconsistency in the end result.…”

“…[6][7][8][9] Noble metal nanostructures were deposited on a POF surface by means of either sputter deposition or chemisorption of nanoparticles from solution phase. [6,7,10] Sputter deposition on PMMA based POF is associated with formation of craters due to evaporation of water content, [10] leading to surface deformation and inconsistency in the end result. On the other hand, the chemisorption of nanoparticles requires PMMA surface modification by multi-step treatment processes to generate active functional groups on its surface [11][12][13][14] as discussed below.…”