Serratiopeptidase: A systematic review of the existing evidence

Bhagat, Shivani; Agarwal, Monika; Roy, Vandana

doi:10.1016/j.ijsu.2013.01.010

Cited by 80 publications

(61 citation statements)

References 18 publications

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“…This finding confirmed the synergistic anti-inflammatory effect of metformin and serratiopeptidase. Additionally, these findings coincide with results of Kim et al [39] in South Korea and Bhagatet [17] et al study in India which clarified the anti-inflammatory effect of metformin and serratiopeptidase enzyme.…”

Section: Discussionsupporting

confidence: 91%

“…Reduction of weight loss was proved to improve both pain and movement in obese patients with knee OA [10]. Many pharmacological agents were used efficiently in treatment of knee OA like systemic non-steroidal anti-inflammatory drugs (NSAIDs) [11], topical creams [12], glucosamine [13], diacerein [14], plateleterich-plasma [15], metformin [16] and serratiopeptidase [17].…”

Section: Managementmentioning

confidence: 99%

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Impact of Metformin and Serratiopeptidase in Obese Patients With Knee Osteoarthritis

Ateia

Al-Edanni

Al-qurtas

2018

Int J Pharm Pharm Sci

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Objective: Knee osteoarthritis is a common disabling chronic disease globally. Many pharmacological agents have been used efficiently in treatment of knee osteoarthritis. This study aims to evaluate metformin and serratiopeptidase together in treatment and stop of osteoarthritis progression by different mechanisms. Methods:Present study was a randomized clinical trial study conducted in Al-Kindi teaching hospital through the period from 1 st January to 30 th of May, 2017 on two groups of 80 osteoarthritis patients (group I; treated with metformin 850 mg oral tablets) and (group II; treated with metformin 850 mg oral tablets and serratiopeptidase 20 mg oral tablets). Parameters of two groups were compared with those of 40 normal healthy controls. Results:Patients in group II showed a highly significant reduction in pain scores post-treatment (p<0.001). Tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1ß) and interleukin 8 (IL-8) levels were significantly lowered among patients in group II treatment (p<0.001). Lower inflammatory parameters levels were observed among healthy controls and the parameters levels of group II patients were lower than those of group I patients. Conclusion:Metformin and serratiopeptidase regimen was efficient and safe in the treatment of knee osteoarthritis.

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Section: Discussionsupporting

confidence: 91%

Section: Managementmentioning

confidence: 99%

Impact of Metformin and Serratiopeptidase in Obese Patients With Knee Osteoarthritis

Ateia

Al-Edanni

Al-qurtas

2018

Int J Pharm Pharm Sci

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“…Shivani Bhagat et al, conducted a systematic review on the evidence available for the use of serratiopeptidase. 6 They reviewed a total of 9 RCTs and concluded that the existing scientific evidence for serratiopeptidase is insufficient to support its use as an analgesic or health supplement. The data on long-term safety of this enzyme is lacking.…”

Section: Discussionmentioning

confidence: 99%

Pattern of use of analgesics in post-operative pain management in adults undergoing laparotomy surgery: a prospective observational study

2018

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Background: Previous studies on post-operative pain document that most patients continue to experience pain after surgery. This study was done to record the drug use for post- operative pain in laparotomy and to determine the patient characteristics that affect their pain score.Methods: A prospective observational study in 250 adult patients undergoing laparotomy surgery from General Surgery and Obstetrics and Gynaecology (OBG) at a tertiary care hospital.Results: Among patients recruited, 161 (64.4%) were females, 134 (53.6 %) from surgery department, mean age 37.29±14.9 years. Caesarean section 85 (73.27%) followed by meshplasty 46 (34.3%) were most common.Parenteral tramadol 100mg (40%) was the most common analgesic post-operative, subsequently shifted to oral. Epidural analgesia used in 31 (12.4%) patients, only from surgery department. First analgesic received within 6 hrs in 55.5 % in surgery and 44.5 % in OBG (Pearson χ2 =2.535, p = 0.111) with mean time to first analgesic 2.85±2.33 hrs. Pain score, using Numerical Rating Scale (NRS) recorded for 200 (80%) patients showed 76 (30.4%) had severe pain on day 1 which decreased to 12 (4.8%) on day 3. Speciality (p=0.01) and nature of surgery (p=0.05) were significantly associated with severity of pain. Gender [OR = 0.55 (95% CI = 0.26, 1.19), p=0.13], nature of surgery [2.32 (1.02, 5.32), p=0.05], speciality [0.35 (0.15, 0.80), p=0.01] and surgical category [0.76 (1.01, 5.32), p=0.05] affected pain score on univariate logistic regression, but were not significant on multivariate analysis.Conclusions: Despite the use of opioids and combination analgesics, one third of patients reported severe pain on the first day after surgery.

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“…It is indicated for the conditions such as back pain, fibromyalgia, migraine headache, rheumatoid arthritis, tension headache, osteoporosis, osteoarthritis, carpal tunnel syndrome, laryngitis, sinusitis, pharyngitis, catarrhal rhinopharyngitis, tonsillitis, chronic bronchitis, bronchial asthma, chronic obstructive pulmonary disease, Crohn's disease, ear infections, ulcerative colitis, heart disease, leg ulcers, autoimmune diseases, psoriasis, allergies, keratitis, uveitis, endophthalmitis, subconjunctival hemorrhage, hyphemas, vitreous hemorrhage, infections, diabetes, atherosclerosis, facial swelling, fibrocystic breast disease, cystitis, epididymitis, episiotomy, hysterectomy, thrombophlebitis, hematomas, septic abortion, pelvic inflammatory disease, salpingitis, sprains and torn ligaments, lacerations, and other traumatic injuries, edema, as well as postoperative inflammation [31,32].…”

Section: General Usesmentioning

confidence: 99%

“…Although the clinical efficacy and safety of serratiopeptidase has been proven in many studies, most of the evidence is based on animal experiments, few uncontrolled clinical trials, and randomized controlled clinical trials of poor quality. Thus, there is a need for further extensive experimental and clinical research in this area [30,31,[58][59][60].…”

Section: Kumarmentioning

confidence: 99%

The Emerging Role of Serratiopeptidase in Oral Surgery: Literature Update

Kumar

2018

Asian J Pharm Clin Res

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Serratiopeptidase, a proteolytic enzyme derived from Serratia E-15 species enterobacteria, is widely used in medical field for its anti-inflammatory, anti-edemic properties, and analgesic properties. It is being used commonly in various specialties such as orthopedics, otolaryngology, gynecology, surgery, pulmonology, ophthalmology, and dentistry. Research has shown that serratiopeptidase is the most effective anti-inflammatory agent compared to other enzyme preparations. This article reviews the efficacy, safety, and applications of serratiopeptidase in oral surgery. This article also discusses the mechanism of action of serratiopeptidase, its contraindications and complications. From the recently published literature, it is clear that the role of serratiopeptidase as a therapeutic agent in oral and maxillofacial surgery is expanding and they hold a promising future as a broad-spectrum anti-inflammatory drug with minimal side effects and complications. Further, research will broaden their applications in the field of medicine and dentistry.

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Serratiopeptidase: A systematic review of the existing evidence

Cited by 80 publications

References 18 publications

Impact of Metformin and Serratiopeptidase in Obese Patients With Knee Osteoarthritis

Impact of Metformin and Serratiopeptidase in Obese Patients With Knee Osteoarthritis

Pattern of use of analgesics in post-operative pain management in adults undergoing laparotomy surgery: a prospective observational study

The Emerging Role of Serratiopeptidase in Oral Surgery: Literature Update

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