Impact of Metformin and Serratiopeptidase in Obese Patients With Knee Osteoarthritis

Abstract

Objective: Knee osteoarthritis is a common disabling chronic disease globally. Many pharmacological agents have been used efficiently in treatment of knee osteoarthritis. This study aims to evaluate metformin and serratiopeptidase together in treatment and stop of osteoarthritis progression by different mechanisms. Methods:Present study was a randomized clinical trial study conducted in Al-Kindi teaching hospital through the period from 1 st January to 30 th of May, 2017 on two groups of 80 osteoarthritis patients (group I; treated with metformin 850 mg oral tablets) and (group II; treated with metformin 850 mg oral tablets and serratiopeptidase 20 mg oral tablets). Parameters of two groups were compared with those of 40 normal healthy controls. Results:Patients in group II showed a highly significant reduction in pain scores post-treatment (p<0.001). Tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1ß) and interleukin 8 (IL-8) levels were significantly lowered among patients in group II treatment (p<0.001). Lower inflammatory parameters levels were observed among healthy controls and the parameters levels of group II patients were lower than those of group I patients. Conclusion:Metformin and serratiopeptidase regimen was efficient and safe in the treatment of knee osteoarthritis.

Evaluating the Effectiveness of Phonophoresis by Piroxicam and Dimethyl Sulfoxide for Women’s With Osteoarthritis Knee Joint

“…Identifying the superiority of the phonophoresis technique to conventional US in OA was conducted using the piroxicam gel, 10 min of treatment per session and mild to moderate degree of knee OA. Results from this study showed that phonophoresis was superior to conventional US and also confirmed the findings of previous reports regarding factors influencing the quality and efficacy of phonophoresis [11,19].…”

“…Knee OA is a common disabling chronic disease globally [11]. OA is a non-inflammatory joint disease, it affects all joints most commonly affected are hip and knee joints, and the affected age group is elderly people.…”

Serratiopeptidase: Insights into the therapeutic applications

“…Serratiopeptidase is a natural molecule that is being used for decades, hence commonly considered as safe. The safety of this enzyme in different areas of therapeutics is supported by several studies [ 15 , 19 , 22 , 48 , 54 , 72 ] in which no side effects or adverse events were reported. However, some studies have reported adverse effects of this molecule, but at a rare frequency.…”

Serratiopeptidase: An integrated View of Multifaceted Therapeutic Enzyme

“…Serratiopeptidase can be used to treat osteoarthritis in combination with metformin. Ateia et al [ 62 ] reported the impact of metformin and serratiopeptidase on knee osteoarthritis in obese patients. Metformin and serratiopeptidase combination tablets were efficient in the treatment of knee osteoarthritis.…”