Serratiopeptidase: Insights into the therapeutic applications

Abstract

Highlights Serrapeptidase has immense applications in therapeutic areas. Serrapeptidase is anti-inflammatory, anti-biofilm, analgesic, and anti-edemic. Serrapeptidase need more scientific understanding for further exploration.

A Randomized Controlled Trial of the Efficacy of Systemic Enzymes and Probiotics in the Resolution of Post-COVID Fatigue

“…There is less variability in the data in the test arm on days 8, 11 and 14 when compared to days 0 and 4 in the test arm as well as when compared to days 8, 11 and 14 in the control arm. The median values of total, physical and mental fatigue are substantially lower on day 4 (19, 13, 5), day 8 (15, 10, 5), day 11 (10, 7, 4) and day 14 (8,5,3), respectively, when compared to day 0 (26,18,8) in the test arm as well as when compared to day 4 (23, 16, 8), day 8 (22,15,7), day 11 (20, 14, 7) and day 14 (19.5, 14, 7) in the control arm (Figure 3). The outliers in the upper range of the test arm represent subjects that were still experiencing fatigue at the end of the 14-day treatment period.…”

“…Lactoferrin and enzymes such as lysozyme, catalase, bromelain and papain are known to function as immunomodulators [ 17 , 18 , 19 , 20 ] as well as in combating oxidative stress [ 21 ]. Serratiopeptidase is used for its anti-inflammatory and analgesic activity [ 22 ]. With this understanding, it is rational to examine the effect of enzymes and probiotics supplementation on COVID-19 induced fatigue.…”

In-vitro Virucidal Activity of Commercial Enzyme Preparations against SARS-CoV-2 Virus

“…Serratiopeptidase is a single enzyme protease preparation. Serratiopeptidase has been previously shown to be effective for biofilm reduction [11]. The rest of the enzyme preparations are multi-enzyme preparations.…”

Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19

“…The anti-inflammatory effects of SEPD were reported in the late 1960s, and since then, it has been popularly used in therapeutics for inflammatory diseases in Japan and many European and Asian countries ( Gupte and Luthra, 2017 ; Tiwari, 2017 ; Jadhav et al, 2020 ). Currently, it is available in United States, Canada and European countries as a natural health supplement or dietary ingredient, rather as a drug ( Jadhav et al, 2020 ).…”

“…The anti-inflammatory effects of SEPD were reported in the late 1960s, and since then, it has been popularly used in therapeutics for inflammatory diseases in Japan and many European and Asian countries ( Gupte and Luthra, 2017 ; Tiwari, 2017 ; Jadhav et al, 2020 ). Currently, it is available in United States, Canada and European countries as a natural health supplement or dietary ingredient, rather as a drug ( Jadhav et al, 2020 ). It has been widely used in the management of pain and inflammation related to joints, sports-related chronic muscular swelling, sprain, scar, ruptured ligaments, chronic swelling and injuries, sinusitis, bronchitis, carpel tunnel syndrome, tooth extraction, breast engorgement, and post-surgery inflammation ( Mazzone et al, 1990 ; Klein and Kullich, 2000 ; Tiwari, 2017 ).…”