Serratiopeptidase – A Cause for Spread of Infection

Abstract

Serratiopeptidase is a proteolytic enzyme that has been used for reducing inflammation, it has antiedemic, analgesic, fibrinolytic and caesinolytic properties. Serratiopeptidase is often used in oral surgery for its anti-inflammatory purpose after impaction surgery, maxillofacial trauma and infections but its use should be limited in cases of abscess due to its fibrinolytic activity. Here, we report a case of a buccal space abscess which had spread into deeper muscular layers after serratiopeptidase administration in a 32-year-old male without any systemic condition. Patient presented with a painful swelling on the right mid region of the face since seven days. Serratiopeptidase was discontinued. After routine blood investigation and ultrasonography, incision and drainage was done and the patient recovered after seven days of treatment.

Role of orally administered enzymes in dental practice: A review

“…The wall of the abscess is formed by the effused and organized fibrin and sometimes the fibrin wall is not strong enough; in those cases the pus finds its way into surrounding cellular texture and results into a diffuse abscess. 5 SP can be prescribed either as a single salt with dosage of 5, 10, 15 mg BD or TDS or as fixed dose combination withs other NSAIDs like PCM & aceclofenac (325 + 100 +15 mg), diclofenac (50 + 10 mg), etc. The usual adult dose of SP ranges from 15 to 60 mg per day.…”

Serratiopeptidase: Insights into the therapeutic applications

“…The explanation of the same has been provided above in the respective section of this review. Further, Stevens-Johnson syndrome [ 73 ] and buccal space abscess [ 74 ] have also been reported as side effects of this molecule. These side effects may be dose dependent or possibly due to a combination effect when used with other drugs.…”

Formulation and development of Serratiopeptidase enteric coated tablets and analytical method validation by UV Spectroscopy

“…SRP is normally recommended for oral administration at a dose of 5–10 mg three times a day [ 1 ]. This enzyme is rapidly and readily absorbed through the intestine and transported directly into the blood circulation [ 4 ]. SRP has been extensively used in Europe and Asia for more than 30 years but is relatively new in the United States and Canada.…”