Serotype Identification of Human Adenoviruses Associated with Influenza-Like Illnesses in the Philippines from 2006–2012 by Microneutralization and Molecular Techniques

Calzado, Catherine; Foronda, Janiza Lianne; Arguelles, Vina Lea; Daga, Chona Mae; Quimpo, M.T.; Lupisan, Socorro; Dapat, Clyde; Saito, Mariko; Okamoto, Michiko; Albano, Pia Marie; Oshitani, Hitoshi

doi:10.1016/j.ijid.2022.02.008

Cited by 1 publication

(1 citation statement)

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“…2 HAdVs are highly contagious, spreading rapidly in households, schools, and military quarters, although HAdV-associated pneumonia is usually observed in newborns and immunodeficient older hosts. 3 In recent years, however, outbreaks of HAdV-associated pneumonia have been reported among immunocompetent children in China, as well as many other countries, [4][5][6][7] resulting in a significant increase in severe morbidity (34.4%) and mortality (28.6%). 3,8 Thus, HAdV-pneumonia in children poses a major public health concern.…”

Section: Introductionmentioning

confidence: 99%

Genome and proteomic analysis of risk factors for fatal outcome in children with severe community‐acquired pneumonia caused by human adenovirus 7

Wei,

Zang,

Zhang

et al. 2023

Journal of Medical Virology

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IntroductionHuman adenovirus 7 (HAdV‐7) is an important viral pathogen of severe pneumonia in children and a serious threat to health.MethodsA cohort of 45 pediatric patients diagnosed with HAdV‐7‐associated severe pneumonia and admitted to the Pediatric Intensive Care Unit at the Children's Hospital of Chongqing Medical University from May 2018 to January 2020 were included. Risk factors of death were analyzed by the Cox proportional risk mode with Clinical data, serum, and nasopharyngeal aspirate adenovirus load, Genome analysis, Olink proteomics, and cytokine profile between dead and surviving patients were also analyzed.ResultsA total of 45 children with a median age of 12.0 months (interquartile range [IQR]: 6.5, 22.0) were included (female 14), including 14 (31.1%) who died. High serum viral load was an independent risk factor for mortality (hazard ratio [HR] = 2.16, 95% confidence interval [CI], 1.04–4.49, p = 0.039). BTB and CNC homology 1 (BACH1), interleukin‐5 (IL‐5), and IL‐9 levels were significantly correlated with serum viral load (p = 0.0400, 0.0499, and 0.0290; r = 0.4663, 0.3339, and −0.3700, respectively), with significant differences between the dead and survival groups (p = 0.021, 0.001, and 0.021).ConclusionsSevere cytokine storm‐associated high serum viral load after HAdV‐7 infection may be the main mechanism responsible for poor prognosis in children.

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