Serotype Distribution and Antimicrobial Resistance of Streptococcus
            pneumoniae Isolates Causing Systematic Infections in Spain,
          1979-1989

Fenoll, Asunción; Bourgon, Cecilia Martín; Múñoz, Rosario; Vicioso, Dolores; Casal, J.

doi:10.1093/clinids/13.1.56

Cited by 273 publications

(129 citation statements)

References 26 publications

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“…Chloramphenicol resistance was found in 2.7% and 1.9% of isolates from Belgium and Germany, respectively, as compared with 0.3% of isolates in this study (Reinert et al, 1995;Verhaegen et al, 1995). The prevalence of penicillin resistance in CSF isolates was 40% and 25% in Spain (1979-89) and France (1993), respectively; 25% of isolates were chloramphenicol resistant (Fenoll et al, 1991;Linares et al, 1992;Olivier et al, 1994). In a recent population-based surveillance of invasive pneumococcal infections in the USA 25% of isolates were resistant to penicillin and 3% to chloramphenicol.…”

Section: Discussionmentioning

confidence: 49%

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Enting¹,

Spanjaard²,

Beek³

et al. 1996

Journal of Antimicrobial Chemotherapy

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Section: Discussionmentioning

confidence: 49%

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Enting¹,

Spanjaard²,

Beek³

et al. 1996

Journal of Antimicrobial Chemotherapy

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“…Many studies [7,8,14,29,30] have reported an increase in the prevalence of antibiotic resistance of laboratory isolates in the last 20 years. These studies fail to address the prevalence of antibiotic-resistant pneumococci in the general population.…”

Section: Discussionmentioning

confidence: 99%

“…Early resistant isolates showed intermediate levels of resistance to penicillin (minimum inhibitory concentration (MIC) 0n12-1 µg\ml) but later, highly resistant isolates (MIC 4-8 µg\ml) [5], and multiply-resistant pneumococci were reported [6]. Reports show a progressive increase in prevalence once resistant strains are introduced into an area, as observed in Spain between 1980 and 1987 [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of carriage of antimicrobial resistant strains of Streptococcus pneumoniae in primary school children in Hong Kong

Boost

O'Donoghue

Dooley³

2001

Epidemiol. Infect.

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SUMMARYA cross-sectional survey was conducted to determine prevalence and assess risk factors for carriage of antibiotic resistant strains of Streptococcus pneumoniae in healthy school children in Hong Kong. Throat swabs were collected from 1455 subjects and written questionnaires providing demographic data and medical history were completed by parents. The overall carriage rate of Streptococcus pneumoniae was 3n5 %, of which 49 % were penicillin resistant. High levels of resistance to tetracycline (73 %), erythromycin (52 %), trimethoprim (66 %) and ciprofloxacin (57 %) were observed. Carriage was associated with presence of a younger sibling (OR l 1n79) and use of antibiotics (OR l 2n31). High use of day care and small size of housing units did not result in a high rate of carriage. The low rate of carriage may be linked to high use of antibiotics, geographical factors or ethnicity. High rates of antibiotic resistance reflect heavy use of antibiotics by general practitioners.

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“…Brain-heart infusion broth plus 0.5 YO yeast extract (BHI-Y) was used as liquid medium. MICs of antibiotics were determined as described previously (Fenoll et al, 1991). Serogrouping of each isolate was carried out at the Instituto de Salud Carlos 111, Majadahonda, Madrid, Spain (Fenoll et al, 1991).…”

Section: Methodsmentioning

confidence: 99%

“…MICs of antibiotics were determined as described previously (Fenoll et al, 1991). Serogrouping of each isolate was carried out at the Instituto de Salud Carlos 111, Majadahonda, Madrid, Spain (Fenoll et al, 1991). Serotyping of selected isolates was carried out a t the Central Public Health Laboratories, Colindale, UK.…”

Section: Methodsmentioning

confidence: 99%

Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F

et al. 1996

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We analysed a collection of 95 multiply antibiotic-resistant pneumococci, recovered since 1988 from 14 Spanish hospitals, that have MlCs 3 0-25 pg benzylpenicillin ml-l. The majority of the isolates were of serogroups 14, 23, 6, 19 and 15, which are currently the serogroups mainly associated with multiresistance in Spain. All of the serogroup 23 isolates were members of the major Spanish serotype 23F multiresistant clone. Similarly, most of the serogroup 6 isolates were members of the major multiresistant serotype 6B clone, or variants of this clone. Eighteen of the 24 isolates of serogroup 1 9 were members of a highly penicillin-resistant clone that appears to be a serotype 19F variant of the major Spanish serotype 23F multiresistant clone. Eighteen of the 25 isolates of serotype 14 were members of a previously uncharacterized highly penicillin-resistant clone. Thirteen of the 16 isolates of serogroup 1 5 were members of a single previously unreported clone of serotype 15F that had moderate levels of resistance to penicillin. Approximately 65 O/ O of the multiresistant pneumococci that are currently circulating in Spain were members of the three new clones of serotype 14, 15F and 19F that we describe here, or the previously described serotype 6B and 23F clones. The other 35% of isolates were minor variants of the major clones, unrelated minor clones, and unique isolates, many of which appeared to have arisen b y horizontal gene transfer events.

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Serotype Distribution and Antimicrobial Resistance of Streptococcus pneumoniae Isolates Causing Systematic Infections in Spain, 1979-1989

Cited by 273 publications

References 26 publications

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Antimicrobial susceptibility of Haemophilus influenzae, Neisseria meningitidis and Streptococcus pneumoniae isolates causing meningitis in The Netherlands, 1993-1994

Prevalence of carriage of antimicrobial resistant strains of Streptococcus pneumoniae in primary school children in Hong Kong

Multiply antibiotic-resistant Streptococcus pneumoniae recovered from Spanish hospitals (1988-1994): novel major clones of serotypes 14, 19F and 15F

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