Serotonin turnover in different duration of sleep recovery in discrete regions of young rat brain after 24h REM sleep deprivation

Senthilvelan, M; Ravindran, R.; Samson, J.; Devi, Rathinasamy Sheela

doi:10.1016/j.braindev.2006.03.001

Cited by 6 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Short-term sleep deprivation increases levels of 5-HT in the hippocampal cycle, with levels quickly returning to normal during sleep rebound (53,54). When Senthilvelan et al deprived rats of REM sleep for 24 hours, the 5-HT cycle, measured after resting for 3 h and 12 h, was increased (55).…”

Section: Discussionmentioning

confidence: 99%

The impact of sleep deprivation on hippocampal-mediated learning and memory in rats

Saygın¹,

Özgüner²,

Önder³

et al. 2017

BLL

View full text Add to dashboard Cite

BACKGROUND: To examine the impact of different types of sleep deprivation on hippocampal-mediated learning and memory in rats. METHODS: Forty-eight Sprague-Dawley male rats were randomly assigned to 1 of 4 equal-size groups: (1) 12 hours of sleep per day (control). (2) total sleep deprivation (TSD), (3) rapid eye movement (REM) deprivation (RD), and (4) sleep restricted to 4 hours per day (SR). All rats were subjected to swimming training in the Morris water maze (MWM). At the end of the experiments, the rats were decapitated, and hippocampus tissue was analyzed for several neurotransmitters and receptors. RESULTS: The time spent at the target quadrant increased from 20.2 to 30.0 seconds in the control group on the third day of the experiment, whereas corresponding values increased from 20.2 to 21.8 seconds in the TSD group, 22.1 to 25.4 seconds in the RD group, and 21.2 to 32.0 sec in the SR group (p = 0.026). On the seventh day of the experiment, the values decreased to 25.0 seconds in controls, 22.5 in the RD group, and 23.6 in the SR group (p = 0.045). The TSD group demonstrated signifi cant decreases in glutamate and serotonin levels compared with the control group. There was a signifi cant increase in 5-HT2 a receptor expression in all intervention groups compared with the controls. CONCLUSIONS: Our results of glutamate levels and 5-HT2a receptor expression in the hippocampus seem to be primarily involved in sleep and memory regulation (Tab. 2, Fig. 4, Ref. 59). Text in PDF www.elis.sk.

show abstract

Section: Discussionmentioning

confidence: 99%

The impact of sleep deprivation on hippocampal-mediated learning and memory in rats

Saygın¹,

Özgüner²,

Önder³

et al. 2017

BLL

View full text Add to dashboard Cite

show abstract

“…There has been some suggestion that it may improve sleep patterns and aid weight loss. A recent study, which investigated the effect of sleep deprivation on 5-HT turnover, indicated that REM sleep modulated the 5-HT turnover in the brain in a region-specific manner [92].…”

Section: Sleep and Pharmacological Treatmentsmentioning

confidence: 99%

Inflammation, Sleep, Obesity and Cardiovascular Disease.

Miller¹,

Cappuccio²

2007

CVP

191

136

View full text Add to dashboard Cite

show abstract

“…In addition, REM SD before the end of the critical period in young rats is known to delay termination of the critical period in the visual cortex (Shaffery et al 2006 ). In sleep-deprived young rats, the ratio of serotonin decreases in the hypothalamus (Senthilvelan et al 2006 ). This study demonstrates that 48-h of REM sleep deprivation in adolescent rats leads to increased locomotor activity, susceptibility to fear, and induced depression-like behavior.…”

Section: Discussionmentioning

confidence: 99%

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

Jung

Noh

2021

Animal Cells and Systems

View full text Add to dashboard Cite

Disruption of sleep due to acute or chronic stress can lead to changes in emotional memory processing. Sleep disturbances are highly prevalent in post-traumatic stress disorder (PTSD), but still, the contribution of sleep deprivation on the susceptibility to PTSD has received little attention. To determine whether rapid eye movement sleep deprivation (SD) alters the development of fear expression or fear-associated memory impairment in adolescent rats, we performed animal emotional behavior tests using an SD animal model with the flowerpot technique. SD rats showed an increase in locomotor activity frequency and a decrease in sucrose consumption compared to control rats. An increase in freezing behavior during shock trials was observed in SD rats. Noticeably, it was observed that when applying the SD condition after fear stimuli exposure, fear extinction was delayed more in SD rats than in control rats. Overall, these results indicate that SD in adolescent rats leads to increased locomotor activity and anhedonic behavior, as well as increased fear expression and delayed fear extinction, suggesting that SD would lead to increased severity of PTSD-like phenotype.

show abstract

Serotonin turnover in different duration of sleep recovery in discrete regions of young rat brain after 24h REM sleep deprivation

Cited by 6 publications

References 7 publications

The impact of sleep deprivation on hippocampal-mediated learning and memory in rats

The impact of sleep deprivation on hippocampal-mediated learning and memory in rats

Inflammation, Sleep, Obesity and Cardiovascular Disease.

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

Contact Info

Product

Resources

About