Serotonin‐transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss

Bonnet, Gemma; Gómez-Abellán, Purificación; Vera, Beatriz; Sánchez-Romera, Juan F.; Hernández-Martínez, Antonio Miguel; Sookoian, Silvia; Pirola, Carlos José; Garaulet, Marta

doi:10.1002/mnfr.201700494

Cited by 6 publications

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References 52 publications

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“…Furthermore, emotional eating has been positively associated with waist circumference (WC) [ 15 , 16 ], abdominal obesity (AO) by WC [ 17 , 18 ], body mass index (BMI) [ 15 , 16 , 19 , 20 ], obesity by BMI [ 6 , 12 , 17 ], obesity by percent body fat [ 18 ], bodyweight gain [ 6 , 21 ], and weight loss impairments [ 21 ]. Moreover, emotional eating has been shown to interact with the physiological and genetic characteristics of the individual for body weight loss effectiveness [ 22 , 23 ]. In addition, obesity and AO are more frequent among those subjects classified as emotional eaters than non-emotional ones [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Emotional Eating and Dietary Patterns: Reflecting Food Choices in People with and without Abdominal Obesity

et al. 2022

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Emotional eating (EE) is food consumption in response to feelings rather than hunger. EE is related to unhealthy food intake and abdominal obesity (AO). However, little evidence exists about the association between EE and dietary patterns (DPs) and EE–AO interaction related to DPs. DPs allow describing food combinations that people usually eat. We analyzed the association of EE with DPs in adults (≥18 years) with AO (WC ≥ 80/90 cm in women/men, respectively; n = 494; 66.8% women;) or without AO (n = 269; 74.2% women) in a cross-sectional study. Principal component analysis allowed identifying four DPs from 40 food groups (validated with a semiquantitative food frequency questionnaire). Among the subjects presenting AO, being “emotional/very-emotional eater” (emotional eating questionnaire) was negatively associated with the “Healthy” DP (fruits, vegetables, olive oil, oilseeds, legumes, fish, seafood) (OR:0.53; 95% CI: 0.33, 0.88, p = 0.013) and positively with the “Snacks and fast food” DP (sweet bread, breakfast cereal, corn, potato, desserts, sweets, sugar, fast food) (OR:1.88; 95% CI: 1.17, 3.03, p = 0.010). Emotional eaters with AO have significantly lower fiber intake, folic acid, magnesium, potassium, vitamin B1, and vitamin C, while they had a higher intake of sodium, lipids, mono and polyunsaturated fatty acids, and saturated fats. In non-AO participants, EE was not associated with any DP (p > 0.05). In conclusion, EE is associated with unhealthy DPs in subjects with AO.

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Section: Introductionmentioning

confidence: 99%

Emotional Eating and Dietary Patterns: Reflecting Food Choices in People with and without Abdominal Obesity

et al. 2022

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“…Yet, the minor allele ( A ) of rs9903062 within SLC6A4 was associated with increased BMI in a recessive genetic model. Previous studies found SLC6A4 was implicated in energy intake, stress induced appetite for sweets, ability to control food intake and emotional eating 9,15–17 . In SLC6A4 knock out mice, 5‐HT reuptake is absent and 5‐HT concentration is markedly reduced 41 .…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies found SLC6A4 was implicated in energy intake, stress induced appetite for sweets, ability to control food intake and emotional eating. 9 , 15 , 16 , 17 In SLC6A4 knock out mice, 5‐HT reuptake is absent and 5‐HT concentration is markedly reduced. 41 These mice also present decreased food intake but increased body fat and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“… 8 , 9 , 10 , 11 , 12 , 13 , 14 Variations in SLC6A4 have also been linked with obesogenic eating behaviors, such as appetite, energy intake, disinhibited eating, and emotional eating. 9 , 15 , 16 , 17 In addition to SLC6A4 , several 5‐HT receptor genes and TPHs, including HTR1B , 18 , 19 HTR2A , 20 , 21 , 22 , 23 HTR2B , 24 HTR2C , 11 , 18 , 20 , 25 , 26 , 27 HTR6 , 28 HTR7 , 19 TPH1 , and TPH2 24 , 29 have also been assessed for potential associations with body weight measures and/or eating behaviors. However, the majority of the results have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

“…To date, the most frequently assessed genetic variations within the 5‐HT systems related to obesity are located at the SLC6A4 gene, although findings are not consistent 8–14 . Variations in SLC6A4 have also been linked with obesogenic eating behaviors, such as appetite, energy intake, disinhibited eating, and emotional eating 9,15–17 . In addition to SLC6A4 , several 5‐HT receptor genes and TPHs, including HTR1B , 18,19 HTR2A , 20–23 HTR2B , 24 HTR2C , 11,18,20,25–27 HTR6 , 28 HTR7 , 19 TPH1 , and TPH2 24,29 have also been assessed for potential associations with body weight measures and/or eating behaviors.…”

Section: Introductionmentioning

confidence: 99%

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Serotonin system genes contribute to the susceptibility to obesity in Black adolescents

Meng

Groth

Hodgkinson

et al. 2021

Obesity Science & Practice

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Objective The importance of the central and peripheral serotonin systems in regulating energy balance and obesity development has been highlighted in animal models. Yet, the role of both serotonin systems has not been systematically assessed in humans. The purpose of this study was to investigate the association of genes within both serotonin systems with obesity outcomes in black adolescents. Methods African–American adolescents (n = 1052) whose mothers participated the Memphis New Mother's Study were assessed. In total, 110 polymorphisms mapped to 10 serotonin genes were examined for their associations with standardized body mass index (BMI‐z) scores and waist circumferences using generalized estimating equation models. Results Over 39% of adolescents were overweight or had obesity. Three single nucleotide polymorphisms (SNPs) within TPH2, HTR3B, and SLC6A4, were significantly associated with BMI‐z scores (p < 1.7 × 10−3). Two SNPs in TPH2 were nominally associated with waist circumferences. One SNP in HTR2C was associated with BMI‐z scores (p = 0.001) and waist circumferences (p = 0.005) only in girls. Tissue‐specific expression indicates that three identified genes are predominantly expressed in the brain. Conclusion The central serotonin system may play a key role in obesity development in black adolescents. Future studies are warranted to explore additional serotonin system genes and their potential obesogenic mechanisms in humans.

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Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression

et al. 2022

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Depressed individuals who carry the short allele for the serotonin-transporter-linked promotor region of the gene are more vulnerable to stress and have reduced response to first-line antidepressants such as selective serotonin reuptake inhibitors. Since depression severity has been reported to correlate with brain iron levels, the present study aimed to characterise the potential antidepressant properties of the iron chelator deferiprone. Using the serotonin transporter knock-out (5-HTT KO) mouse model, we assessed the behavioural effects of acute deferiprone on the Porsolt swim test (PST) and novelty-suppressed feeding test (NSFT). Brain and blood iron levels were also measured following acute deferiprone. To determine the relevant brain regions activated by deferiprone, we then measured c-Fos expression and applied network-based analyses. We found that deferiprone reduced immobility time in the PST in 5-HTT KO mice and reduced latency to feed in the NSFT in both genotypes, suggesting potential antidepressant-like effects. There was no effect on brain or blood iron levels following deferiprone treatment, potentially indicating an acute iron-independent mechanism. Deferiprone reversed the increase in c-Fos expression induced by swim stress in 5-HTT KO mice in the lateral amygdala. Functional network analyses suggest that hub regions of activity in mice treated with deferiprone include the caudate putamen and prefrontal cortex. The PST-induced increase in network modularity in wild-type mice was not observed in 5-HTT KO mice. Altogether, our data show that the antidepressant-like effects of deferiprone could be acting via an iron-independent mechanism and that these therapeutic effects are underpinned by changes in neuronal activity in the lateral amygdala.

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Serotonin‐transporter promoter polymorphism modulates the ability to control food intake: Effect on total weight loss

Abstract: SLC6A4-promoter variant is associated with the ability to control food intake and interacts with emotional eating to modulate total weight loss.

Cited by 6 publications

References 52 publications

Emotional Eating and Dietary Patterns: Reflecting Food Choices in People with and without Abdominal Obesity

Emotional Eating and Dietary Patterns: Reflecting Food Choices in People with and without Abdominal Obesity

Serotonin system genes contribute to the susceptibility to obesity in Black adolescents

Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression

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