Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women

Herman, Aryeh I.; Kaiss, Kristi M.; Ma, Rui; Philbeck, John W.; Hasan, Asfar; Dasti, Humza; DePetrillo, Paolo B.

doi:10.1002/ajmg.b.30135

Cited by 40 publications

(42 citation statements)

References 20 publications

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“…In the current study, SS subjects tended to drink more and to be of a younger current age than LL subjects, which is consistent with the finding of Herman et al (2005) that binge drinking may be greater in young college-aged adults with the SS genotype. However, the current study found no significant relationships between 5-HTT genotype and age of onset of alcoholism, which is consistent with family-based studies reporting no differential association of the L or S allele with early onset of alcoholism in offspring (Samochowiec et al, 2006).…”

Section: Discussionsupporting

confidence: 91%

Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

Johnson

Javors

Roache

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Serotonin transporter (5-HTT) activity is greater in carriers of the long (L) vs. short (S) alleles of the 5-HTT-linked polymorphic region (5′-HTTLPR) among healthy control subjects but not alcoholdependent adults. In 198 alcoholics, we determined the relationship between current or lifetime drinking and platelet 5-HTT function and density among allelic variants of the 5′-HTTLPR. SS subjects were younger than L-carriers (LL and LS) (p < 0.0085) and had fewer years of lifetime drinking. For L-carriers, the mean of B max for paroxetine binding, but not V max for serotonin (5-HT) uptake, was lower than that for SS subjects (p < 0.05). More L-carriers than their SS counterparts had V max for 5-HT uptake below 200 nmol/10 7 platelets-min (p < 0.05) and B max for paroxetine binding below 600 nmol/mg protein (p < 0.06). Current drinking (drinks per day during the past 14 days) correlated positively with K m and V max of platelet 5-HT uptake (p < 0.05) and negatively with B max , but not K d , of paroxetine binding (p < 0.05) for L-carriers alone. Years of lifetime drinking correlated negatively with K m and V max of platelet 5-HT uptake (p < 0.05) and B max , but not K d , of paroxetine binding (p < 0.05) for L-carriers alone. Among L-carriers alone, there were higher levels of platelet 5-HT uptake and lower levels of platelet paroxetine binding with increased drinking, and more lifetime drinking was associated with modestly lower levels of 5-HT uptake and paroxetine binding. Thus, 5-HTT expression varies with current and lifetime drinking in L-carriers alone.

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Section: Discussionsupporting

confidence: 91%

Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

Johnson

Javors

Roache

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…A study was designed by Herman et al 83 to examine the gene--gene (GxG) interaction between the functional polymorphism in the promoter region of the 5HTTLPR and the MAOA-mVNTR polymorphism related to binge drinking behavior in college females. Interestingly, the highest risk was found in homozygous for the short variant allele of the 5HTTLPR (SS) in combination with the higher activity forms of the MAOA-mVNTR (HH) (OR = 3.11, 95% CI = 1.14-18.10), and the lowest risk was found in individuals carrying at least one long variant of the 5HTTLPR (LL or LS) in combination with higher activity MAOA-mVNTR alleles (HH) (OR = 0.46, 95% CI = 0.28-0.71) 83 .…”

Section: Alcohol Dependencementioning

confidence: 99%

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

Nishioka¹,

Perin²,

Sampaio³

et al. 2011

Rev. psiquiatr. clín.

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Introduction: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. Objective: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. Method: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: "MAOA and human behavior" and "MAOA and psychiatry". Results: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. Discussion: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior ("hyperactive behaviors"), and the high activity alleles of the gene with "hypoactive behaviors", such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in "hyperactive" and "hypoactive" disorders.

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“…Herman et al (2005) also reported that the S allele was associated with a higher risk for binge drinking among women. Hammoumi et al (1999) showed that Caucasian subjects with the SS and SL genotypes had increased frequency of binge drinking, compared to the LL genotype.…”

Section: -Httlpr Polymorphism and Alcohol Use Problemsmentioning

confidence: 95%

“…Matsushita et al (2001) reported a higher frequency of the SS genotype among a sub-group of Japanese male adult alcoholics with binge drinking behaviors. Herman et al reported an association between the S allele and alcoholism in young Caucasian women (Herman et al 2005). Hallikainen et al (1999) found that the S allele was associated with early onset alcoholism in a Finnish study.…”

Section: -Httlpr Polymorphism and Alcohol Use Problemsmentioning

confidence: 98%

“…The S alleles were also associated with early onset of binge drinking when compared to LL variants. A study among college students at George Washington University showed that the S allele was associated with increased risk of binge drinking (Herman et al 2005). Matsushita et al (2001) reported a higher frequency of the SS genotype among a sub-group of Japanese male adult alcoholics with binge drinking behaviors.…”

Section: -Httlpr Polymorphism and Alcohol Use Problemsmentioning

confidence: 99%

See 1 more Smart Citation

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

et al. 2015

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Alcohol use and sexual risk behaviors are multidimensional phenomena involving many genetic and environmental factors. 5-HT transporter linked promoter region (5-HTTLPR) polymorphism constitutes an important factor affecting alcohol use problems and risky sexual behaviors. This paper narratively reviews studies on 5-HTTLPR polymorphism and its associations with alcohol use problems and sexual risk behaviors. We searched the electronic databases, PubMed, Ovid, and Google Scholar for articles using MeSH terms. Relevant articles were reviewed and eligible articles were selected for the study. Many studies have reported a significant but moderate association between 5-HTTLPR polymorphism and alcohol use problems. These studies have implicated the presence of at least one S allele to be associated with significant increases in alcohol use problems. Similarly, some studies associate the S allele with increased sexual risk behaviors. Effective alcohol cessation initiatives and STI/HIV prevention programs should be modified to account for 5-HTTLPR polymorphism before planning interventions; genetic effects could moderate the intervention effect.

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Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women

Cited by 40 publications

References 20 publications

Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

Can serotonin transporter genotype predict serotonergic function, chronicity, and severity of drinking?

O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos

A review of 5-HT transporter linked promoter region (5-HTTLPR) polymorphism and associations with alcohol use problems and sexual risk behaviors

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