Serotonin-System Polymorphisms (5-HTTLPR and -1438G/A) and Responses of Patients With Bulimic Syndromes to Multimodal Treatments

Steiger, Howard; Joober, Ridha; Gauvin, Lise; Bruce, Kenneth R.; Richardson, Jodie; Israël, Mimi; Anestin, Annélie S.; Whitehead, Richard; Groleau, Patricia

doi:10.4088/jcp.v69n1006

Cited by 27 publications

(23 citation statements)

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“…Few studies have also examined this variant in the context of bulimia nervosa. For instance, the low functioning allele of -1438G/A (G) has been found to be associated with poorer treatment response (Steiger et al , 2008). Another study implicates the G allele in increased impulsivity and reduced sensitivity to post-synaptic serotonin in women with bulimia nervosa (Bruce et al , 2005).…”

Section: Discussionmentioning

confidence: 99%

Preliminary evidence for the role of HTR2A variants in binge eating in young women

Koren¹,

Duncan²,

Munn‐Chernoff³

et al. 2014

Psychiatric Genetics

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Objective We examined the association between 15 single nucleotide polymorphisms (SNPs) in HTR2A and characteristics of disordered eating, including weight/shape concerns, binge eating (with or without loss of control) and compensatory behaviors (purging and non-purging). Whether a lifetime history of major depressive disorder (MDD) moderated or mediated this association was also investigated. Method A sample of 1533 twin women of Caucasian descent that were part of the Missouri Adolescent Female Twin Study was used. Data were collected using self-report responses to a semi-structured interview. Logistic regression analyses were used to examine the association between weight/shape concerns, binge eating and compensatory behaviors and SNPs (where carriers of the minor allele were coded as 1). Results Two SNPs, rs6561333 and rs2296972, showed a protective influence against binge eating, with rs2296972 being significant at a trend level after application of the False Discovery Rate. The SNP was not associated with MDD nor did MDD moderate its putative relation with binge eating. Discussion Pending replication, our analyses provide preliminary evidence for intronic SNPs in HTR2A and their association with binge eating. Given the well-documented role of serotonergic dysfunction in eating psychopathology, this report warrants considerable further study.

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Section: Discussionmentioning

confidence: 99%

Preliminary evidence for the role of HTR2A variants in binge eating in young women

Koren¹,

Duncan²,

Munn‐Chernoff³

et al. 2014

Psychiatric Genetics

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“…In the BN meta-analysis we considered the study by Steiger et al on the largest BN sample 22 ; in the meta-analysis considering all eating disorders we removed this study 22 because we included a more recent case-control study published by the same team in which a larger sample has been considered, even without separate data for AN and BN. 23 Fifteen studies met the criteria for inclusion in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, eight studies included AN samples [24][25][26][27][28][29][30][31] and seven included BN samples. 22,24,27,28,[32][33][34] Three additional studies have been included, two being performed on samples of eating disorder patients (AN and BN considered together) 23,35 and one being performed on a sample of BED patients. 36 The methodological quality of the included studies according to the Newcastle-Ottawa scale 12 is shown in Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…5,38,39 If we assume that temperamental differences between AN and BN may reflect a different genetic modulation, present results could be considered in line with the previous ones linking the S allele with both high anxiety-traits 40 and low impulsivity. 41,42 Moreover, only two studies 22,23 have considered the recently identified A/G SNP within the 5-HTTLPR insertion. 43 The 5-HTTLPR actually was conceptualized as having three allelic variants: LA, LG, and S. Of these alleles, only the LA allele is highly functioning (with regards to promoter activity), while the LG apparently behaves like the lowexpressing S allele.…”

Section: Discussionmentioning

confidence: 99%

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The 5‐HTTLPR polymorphism and eating disorders: A meta‐analysis

Calati

Ronchi

Bellini

et al. 2011

Intl J Eating Disorders

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“…This finding is consistent with a prior study conducted in posttraumatic stress disorder patients [20] reporting that individuals carrying at least 1 S allele displayed severer posttraumatic stress disorder symptoms 6 months following treatment compared to individuals homozygous for the L allele. In a study focussing on bulimia [44], the SS genotype was associated with poorer treatment outcome as well. However, opposite results have also been reported, demonstrating better therapy outcomes at the immediate posttreatment assessment [24,25] or in the long term [21,25] in individuals carrying the S allele compared to homozygous L allele carriers.…”

Section: Discussionmentioning

confidence: 99%

The Return of Fear: Variation of the Serotonin Transporter Gene Predicts Outcome of a Highly Standardized Exposure-Based One-Session Fear Treatment

Wannemüller

Moser

Kumsta

et al. 2018

Psychother Psychosom

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Background: Methodological problems of existing research, such as the application of unstandardized treatments in heterogeneous samples, has hampered clear conclusions about the extent and direction to which allelic variation of the serotonin transporter gene-linked polymorphic region (5- HTTLPR) is associated with a differential response to psychological treatment. The present study aimed to investigate the effects of the 5-HTTLPR genotype on treatment outcome under highly standardized environmental conditions. Methods: We treated 222 medication-free adults highly fearful of spiders, dental surgeries or blood, injuries and injections with a highly standardized exposure-based 1-session treatment and genotyped them for the 5-HTTLPR. Participants' subjective fear was assessed before, immediately after treatment and at 7 months of follow-up. Results: There were no differences between 5-HTTLPR genotypes in treatment outcome effects at the immediate posttreatment assessment. However, we observed a highly significant genotype × treatment effect (p = 0.004) at the 7-month follow-up. Fear levels of homozygous S allele carriers differed from those heterozygous (p = 0.026) and homozygous (p = 0.012) for the L allele. Compared to posttreatment assessment, LL allele carriers exhibited a further fear decrease at the follow-up assessment. In contrast, SS allele carriers displayed a strong return of fear. Conclusions: Results suggest that genetic variation of the serotonin transporter is associated with differential stability of inhibitory learning processes, potentially reflecting heightened susceptibility for context-related processes that facilitate a return of fear in S allele carriers. If replicated, results suggest the 5-HTTLPR might represent a biomarker for the long-term outcome of brief exposure-based fear treatments and might inform genotype-based selection of psychotherapeutic interventions.

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Serotonin-System Polymorphisms (5-HTTLPR and -1438G/A) and Responses of Patients With Bulimic Syndromes to Multimodal Treatments

Cited by 27 publications

References 0 publications

Preliminary evidence for the role of HTR2A variants in binge eating in young women

Preliminary evidence for the role of HTR2A variants in binge eating in young women

The 5‐HTTLPR polymorphism and eating disorders: A meta‐analysis

The Return of Fear: Variation of the Serotonin Transporter Gene Predicts Outcome of a Highly Standardized Exposure-Based One-Session Fear Treatment

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