The 5‐HTTLPR polymorphism and eating disorders: A meta‐analysis

Abstract

To be carrier of the 5-HTTLPR S allele seem to represent a risk factor for eating disorders, especially for AN. However, considering the reported high between-study heterogeneity, future studies should focus on more homogeneous endophenotype.

SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation

“…Furthermore, two single-nucleotide polymorphisms (SNPs) within 5-HTTLPR, rs25531 and rs25532, have been found to affect transcriptional activity (Murphy and Lesch, 2008). In accordance with findings in the SERT-KO mice, the low-expressing s allele of the 5-HTTLPR has been associated with anxiety-related personality traits Holmes et al, 2003b) and neuropsychiatric conditions such as bipolar disorder (Cho et al, 2005;Lasky-Su et al, 2005), autism (Huang and Santangelo, 2008), obsessive-compulsive disorder (OCD) (Lin, 2007), 610 KRISTENSEN ET AL. eating disorders (Calati et al, 2011), major depressive disorder (Clarke et al, 2010;Kiyohara and Yoshimasu, 2010), and predisposition to develop depression in response to stressful life events (Caspi et al, 2003). However, two recent meta-analyses have failed to support a correlation among 5-HTTLPR, stress, and depression (Munafò et al, 2009;Risch et al, 2009), and this geneby-environment interaction is still the subject of debate (Risch et al, 2009;Wankerl et al, 2010).…”

Epigenetics of Human Obesity: A Link Between Genetics and Nutrition

“…In a recent study, Crujeira et al [76] found that NPY and POMC methylation levels reflect a putative epigenetic regulation implicated in the weight regain process. Also, the promoter region hypermethylation of the serotonin transporter gene ( SLC6A4), previously related with eating disorders and body weight [77,78], was associated with an increase in BMI, body weight and waist circumference [79].…”

Genetic aspects of binge eating disorder Part 2. Molecular genetics and pharmacogenetic approaches

“…На выборке из 71 женщи-ны с ВЕD с ожирением и без такового (в группе контро-ля с нормальным весом была 61 женщина) показано, что не S-, а L-аллель 5-HTTLPR увеличивает риск раз-вития ВЕD [37]. Согласно результатам метаанализов, S-аллель 5-HTTLPR может являться фактором риска развития расстройств пищевого поведения в целом [38], особенно анорексии [28], для которой получены наи-лучшие показатели достоверности [39]. Однако доказа-тельств влияния на риск развития ВЕD до сих пор нет.…”