Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation

Gong, Pingyuan; Liu, Jinting; She, Li; Zhou, Xiaolin

doi:10.1016/j.psyneuen.2014.09.001

Cited by 21 publications

(15 citation statements)

References 56 publications

(81 reference statements)

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“…However, only HTR1A-G interacted with alexithymia (particularly the facets of difficulty identifying and describing feelings) to explain the expected increase in depression during antiviral treatment, controlled for sociodemographic and HCV-related factors, in line with separate findings for HCV [7] and alexithymia [4]. …”

Section: Discussionsupporting

confidence: 58%

“…Furthermore, alexithymia contributes substantially to a greater rate of somatic IFN-related side effects in HCV patients [9]. This study aimed to replicate previous findings regarding the association between alexithymia and 5-HT-related gene polymorphisms [4,5] and, for the first time to our knowledge, to investigate longitudinally whether genetic factors (5-HTTLPR and HTR1A) and alexithymia may contribute to vulnerability to depression during IFN treatment in HCV patients.…”

Section: Introductionmentioning

confidence: 68%

“…Laboratory studies have found possible candidate genes associated with alexithymia [3], particularly functional gene polymorphisms in the upstream regulatory region of the serotonin (5-HT) transporter coding sequence (5-HT-transporter-linked polymorphic region; 5-HTTLPR) and the 5-HT receptor (C-10119G of the HTR1A) [4,5]. Previous genetic investigations have recruited nonclinical subjects from general-population or convenience samples but, to our knowledge, no study has investigated clinical implications in terms of whether alexithymia interacts with 5-HT-related gene polymorphisms to increase the vulnerability to emotional distress.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C

Porcelli

Cozzolongo

Cariola³

et al. 2015

Psychopathology

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Background: Previous studies have shown that alexithymia is associated with gene polymorphisms that regulate the availability of serotonin (5-HT) in the brain. Since the 5-HT network is involved in interferon (IFN)-induced depression, this paper aimed to investigate the role of alexithymia and the functional gene variants of the 5-HT1A receptor (HTR1A) and the 5-HT transporter (5-HTTLPR) in induction of depression during antiviral treatment. Methods: The depressive symptoms of 130 consecutive patients with chronic hepatitis C and no current psychopathology were measured during treatment with IFN and ribavirin (6-12 months) and at a 6-month follow-up. At baseline, alexithymia and 2 genotypes (5-HTTLPR and HTR1A) were also assessed. Results: Patients with homozygosity for HTR1A-G and 5-HTTLPR long alleles had significantly higher levels of alexithymia. After controlling for sociodemographic and disease-related factors, alexithymia and HTR1A-G polymorphism, both separately (20-22%) and jointly (14-16%), significantly and independently predicted the development of IFN-induced depression. Conclusions: Subjects carrying HTR1A-G and 5-HTTLRP double long alleles are more vulnerable to alexithymia. Also patients with a higher level of alexithymia and the HTR1A-G gene variant are more vulnerable to experiencing IFN-induced depressive symptoms. The clinical implications of targeting alexithymia and HTR1A receptors as a possible treatment option for mood disorders should be investigated in further studies.

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Section: Discussionsupporting

confidence: 58%

Section: Introductionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C

Porcelli

Cozzolongo

Cariola³

et al. 2015

Psychopathology

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“…96 Conversely, depressed patients with the CC genotype showed better performance in a battery of 9 cognitive tests. 97 In healthy Han Chinese people, the CG/GG genotype has been linked with difficulty to identify one's own feelings and in forming close attachments 98 or romantic relationships, 99 which could relate to depression susceptibility. In panic disorder, the CC genotype is associated with increased fractional anisotropy of the left cingulate gyrus.…”

Section: Htr1a Rs6295 and Phenotypic/brain Network Alterationsmentioning

confidence: 99%

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

Albert

François

Vahid-Ansari

2019

jpn

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Major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microRNA, alternative splicing) mechanisms implicated in mental illness, focusing on a key serotonin-related regulator, the serotonin 1A (5-HT 1A) receptor. Functional single-nucleotide polymorphisms and stress-induced DNA methylation of the 5-HT 1A promoter converge to differentially alter pre-and postsynaptic 5-HT 1A receptor expression associated with major depression and reduced therapeutic response to serotonergic antidepressants. Major depression is also associated with altered levels of splice factors and microRNA, posttranscriptional mechanisms that regulate RNA stability. The human 5-HT 1A 3′-untranslated region is alternatively spliced, removing microRNA sites and increasing 5-HT 1A expression, which is reduced in major depression and may be genotype-dependent. Thus, the 5-HT 1A receptor gene illustrates the convergence of genetic, epigenetic and posttranscriptional mechanisms in gene expression, neurodevelopment and neuroplasticity, and major depression. Understanding gene regulatory mechanisms could enhance the detection, categorization and personalized treatment of major depression.

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“…Love-related behaviors, such as pair bonding and affective affiliation, are shown to be associated with the serotonin levels in the brain 4 5 6 7 8 9 . In non-human animals, decreasing serotonin levels via 5-HT1A receptor agonists diminishes female sexual receptivity and induces aggression towards male mates 6 8 .…”

mentioning

confidence: 99%

The association between romantic relationship status and 5-HT1A gene in young adults

Liu

Gong

Zhou

2014

Sci Rep

Self Cite

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What factors determine whether or not a young adult will fall in love? Sociological surveys and psychological studies have shown that non-genetic factors, such as socioeconomic status, external appearance, and personality attributes, are crucial components in romantic relationship formation. Here we demonstrate that genetic variants also contribute to romantic relationship formation. As love-related behaviors are associated with serotonin levels in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene is related to relationship status in 579 Chinese Han people. We found that 50.4% of individuals with the CC genotype and 39.0% with CG/GG genotype were in romantic relationship. Logistic regression analysis indicated that the C-1019G polymorphism was significantly associated with the odds of being single both before and after controlling for socioeconomic status, external appearance, religious beliefs, parenting style, and depressive symptoms. These findings provide, for the first time, direct evidence for the genetic contribution to romantic relationship formation.

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Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation

Cited by 21 publications

References 56 publications

Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C

Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

The association between romantic relationship status and 5-HT1A gene in young adults

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