The association between romantic relationship status and 5-HT1A gene in young adults

Liu, Jinting; Gong, Pingyuan; Zhou, Xiaolin

doi:10.1038/srep07049

Cited by 14 publications

(7 citation statements)

References 16 publications

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“…Fifthly, serotonin shows an effect on sexual relationships in the non-Caucasian sample: HTR2a variation was linked to SOI-R scores. This corroborates suggestions that serotonin plays a role in sexual dyads: variation in HTR1a has previously been found to relate to whether or not the carrier is in a romantic relationship (Liu et al 2014 ), which ties in well with our finding that variants in this gene are linked to the avoidant attachment style in the subclinical sample, in that dispositional attachment style is likely to influence whether or not an individual is motivated, and able, to find a partner. Despite these surface differences between the findings related to the three samples, chi-squared tests found no statistically significant differences between the frequency of positive and null results between the non-clinical Caucasian sample (Pearce et al 2017 ) and either the subclinical or non-Caucasian samples presented here, excepting the result discussed for OXTR .…”

Section: Discussionsupporting

confidence: 92%

The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study

Pearce

Wlodarski

Machin

et al. 2018

Adaptive Human Behavior and Physiology

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ObjectivesSociality is underpinned by a variety of neurochemicals. We previously showed, in a large healthy Caucasian sample, that genes for different neurochemicals are typically associated with differing social domains (disposition, romantic relationships and networks). Here we seek to confirm the validity of these findings by asking whether they replicate in other population samples.MethodsWe test for associations between the same 24 Single Nucleotide Polymorphisms (SNPs) and measures of sociality as previously, in two smaller independent samples: Caucasian individuals with histories of mental illness (subclinical sample) (N = 140), and non-Caucasian individuals (N = 66). We also combined the relevant SNPs and social measures into 18 distinct neurochemical/social domain categories to examine the distribution of significant associations across these.ResultsIn the subclinical Caucasian sample, we confirm previous associations between (i) specific oxytocin and dopamine receptor gene SNPs and sexual attitudes and behavior, and (ii) two SNPs associated with dopamine receptor 2 and feelings of inclusion in the local community. In the non-Caucasian sample, we replicate the previous association between an oxytocin receptor SNP and anxious attachment. More generally, chi-squared tests indicated that the distribution of significant associations for each neurochemical across the three social domains did not differ significantly between the original sample and either of the new samples, except for oxytocin in the non-Caucasian sample.ConclusionsThese results corroborate both the SNP-specific and broader neurochemical associations with particular facets of sociality in two new populations, thereby confirming the validity of the previous findings.Electronic supplementary materialThe online version of this article (10.1007/s40750-018-0101-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study

Pearce

Wlodarski

Machin

et al. 2018

Adaptive Human Behavior and Physiology

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“…For instance, both the dopamine and opioid systems have been shown to interact to maintain monogamous pair bonds in prairie voles (15,38). In humans, DRD2 and HTR2A variation has been linked to different "loving styles" (39) and DRD1 and DRD2 genotypes have been linked to age at first sexual intercourse (40), whereas HTR1A variation is associated with romantic relationship formation (41). In addition, OPRM1 and HTR2A have been associated with variation in mate-choice success differentially in the sexes in "speed-dating" situations (42).…”

mentioning

confidence: 99%

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Pearce

Wlodarski

Machin

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

115

137

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There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved. We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles.

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“…96 Conversely, depressed patients with the CC genotype showed better performance in a battery of 9 cognitive tests. 97 In healthy Han Chinese people, the CG/GG genotype has been linked with difficulty to identify one's own feelings and in forming close attachments 98 or romantic relationships, 99 which could relate to depression susceptibility. In panic disorder, the CC genotype is associated with increased fractional anisotropy of the left cingulate gyrus.…”

Section: Htr1a Rs6295 and Phenotypic/brain Network Alterationsmentioning

confidence: 99%

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

Albert

François

Vahid-Ansari

2019

jpn

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Major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microRNA, alternative splicing) mechanisms implicated in mental illness, focusing on a key serotonin-related regulator, the serotonin 1A (5-HT 1A) receptor. Functional single-nucleotide polymorphisms and stress-induced DNA methylation of the 5-HT 1A promoter converge to differentially alter pre-and postsynaptic 5-HT 1A receptor expression associated with major depression and reduced therapeutic response to serotonergic antidepressants. Major depression is also associated with altered levels of splice factors and microRNA, posttranscriptional mechanisms that regulate RNA stability. The human 5-HT 1A 3′-untranslated region is alternatively spliced, removing microRNA sites and increasing 5-HT 1A expression, which is reduced in major depression and may be genotype-dependent. Thus, the 5-HT 1A receptor gene illustrates the convergence of genetic, epigenetic and posttranscriptional mechanisms in gene expression, neurodevelopment and neuroplasticity, and major depression. Understanding gene regulatory mechanisms could enhance the detection, categorization and personalized treatment of major depression.

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The association between romantic relationship status and 5-HT1A gene in young adults

Cited by 14 publications

References 16 publications

The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study

The Influence of Genetic Variation on Social Disposition, Romantic Relationships and Social Networks: a Replication Study

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm

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