Serotonin in the Regulation of Brain Microcirculation

Cohen, Zvi; Bonvento, Gilles; Lacombe, Pierre; Hamel, Edith

doi:10.1016/s0301-0082(96)00033-0

Cited by 271 publications

(217 citation statements)

References 138 publications

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“…Kish et al, 2002), while cocaine may affect dopaminergic networks (Volkow et al 2001) and cannabis the dopaminergic system (through interaction between the endocannabinoid and dopaminergic system, Ng Cheong Ton & Gardner 1986; Giuffrida et al 1999). Thus this data is consistent with functional neuroimaging studies indicating that ecstasy/polydrug-related neurotransmitter changes may be concentrated in the dorsolateral and parietal regions of the prefrontal cortex (Cohen et al, 1996), and in addition may give rise to significantly lower grey matter concentrations in multiple brain regions (bilateral BA 18 and cerebellum,left BA 21 and left BA 45, as well as the midline brainstem; Cowan et al 2003). Memory updating has been particularly linked to the dorsolateral prefrontal cortex (GoldmanRakic, 1996) while performance on the letter-updating task is most strongly associated with the left fronto-polar cortex ( Van-der-Linden et al, 1999).…”

Section: Geusau Et Al's 2004 Findings) or Inhibitionsupporting

confidence: 77%

“…Although outside the scope of this study, it is possible that while ecstasy may affect memory updating and access through serotonergic depletions in the dorsolateral and parietal prefrontal regions (Cohen et al, 1996), cannabis may affect hippocampal areas resulting in deficits in short-term memory (e.g. Solowij et al, 1992;Solowij et al, 2002).…”

Section: Geusau Et Al's 2004 Findings) or Inhibitionmentioning

confidence: 99%

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The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory

et al. 2005

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Rationale/Objectives: Recent theoretical models suggest that the central executive may not be a unified structure. The present study explored the nature of central executive deficits in ecstasy users. Methods: In Study One, 27 ecstasy users and 34 nonusers were assessed using tasks to tap memory updating (computation span; letter updating) and access to long-term memory (a semantic fluency test and the Chicago word fluency test). In Study Two, 51 ecstasy users and 42 nonusers completed tasks that assess mental set switching (number/letter and plus/minus) and inhibition (random letter generation). Results: MANOVA revealed that ecstasy users performed worse on both tasks used to assess memory updating, and on tasks to assess access to long-term memory (C-and S-letter fluency). However, notwithstanding the significant ecstasy-group related effects, indices of cocaine and cannabis use were also significantly correlated with most of the executive measures. Unexpectedly, in Study Two, ecstasy users performed significantly better on the inhibition task producing more letters than nonusers. No group differences were observed on the switching tasks. Correlations between indices of ecstasy use and number of letters produced were significant. Conclusions: The present study provides further support for ecstasy/polydrug related deficits in memory updating and in access to long-term memory. The surplus evident on the inhibition task should be treated with some caution as this was limited to a single measure and has not been supported by our previous work.

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Section: Geusau Et Al's 2004 Findings) or Inhibitionsupporting

confidence: 77%

Section: Geusau Et Al's 2004 Findings) or Inhibitionmentioning

confidence: 99%

The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory

et al. 2005

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“…In addition, 8′-hydroxy-dihydroergotamine, the major metabolite of the antimigraine drug dihydroergotamine, may induce a persistent desensitization of 5-HT 2B receptors, which may contribute to its therapeutic efficacy (Schaerlinger et al 2003). The study of 5-HT 2B receptor blockade in migraine prophylaxis is awaited to substantiate the presumed hypersensitivity of these receptors in migraine and, hence, their suspected role in the initiation of the neurogenic inflammatory response (Cohen et al 1996;Fozard and Kalkman 1994;Kalkman 1994;Schmuck et al 1996). 5-HT 3 , 5-HT 4 , 5-ht 5A/5B , 5-HT 6 , and 5-HT 7 receptors…”

Section: -Ht 2 Receptor Subtypesmentioning

confidence: 99%

Current and prospective pharmacological targets in relation to antimigraine action

Mehrotra

Gupta

Chan

et al. 2008

Naunyn-Schmied Arch Pharmacol

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Migraine is a recurrent incapacitating neurovascular disorder characterized by unilateral and throbbing headaches associated with photophobia, phonophobia, nausea, and vomiting. Current specific drugs used in the acute treatment of migraine interact with vascular receptors, a fact that has raised concerns about their cardiovascular safety. In the past, α-adrenoceptor agonists (ergotamine, dihydroergotamine, isometheptene) were used. The last two decades have witnessed the advent of 5-HT 1B/1D receptor agonists (sumatriptan and second-generation triptans), which have a well-established efficacy in the acute treatment of migraine. Moreover, current prophylactic treatments of migraine include 5-HT 2 receptor antagonists, Ca 2+ channel blockers, and β-adrenoceptor antagonists. Despite the progress in migraine research and in view of its complex etiology, this disease still remains underdiagnosed, and available therapies are underused. In this review, we have discussed pharmacological targets in migraine, with special emphasis on compounds acting on 5-HT (5-HT 1-7 ), adrenergic (α 1 , α 2, and β), calcitonin gene-related peptide (CGRP 1 and CGRP 2 ), adenosine (A 1 , A 2 , and A 3 ), glutamate (NMDA, AMPA, kainate, and metabotropic), dopamine, endothelin, and female hormone (estrogen and progesterone) receptors. In addition, we have considered some other targets, including gamma-aminobutyric acid, angiotensin, bradykinin, histamine, and ionotropic receptors, in relation to antimigraine therapy. Finally, the cardiovascular safety of current and prospective antimigraine therapies is touched upon.

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“…Since pial arterioles are resistance vessels that control global blood supply to the brain (Cohen et al, 1996), it is important to investigate the role of increased blood content of Fg in pial circulation. Increased venular leakage leads to edema formation in the microcirculatory bed affecting the arteriolar function.…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen-Induced Increased Pial Venular Permeability in Mice

Muradashvili

Qipshidze

Munjal

et al. 2011

J Cereb Blood Flow Metab

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Elevated blood level of Fibrinogen (Fg) is commonly associated with vascular dysfunction. We tested the hypothesis that at pathologically high levels, Fg increases cerebrovascular permeability by activating matrix metalloproteinases (MMPs). Fibrinogen (4 mg/mL blood concentration) or equal volume of phosphate-buffered saline (PBS) was infused into male wild-type (WT; C57BL/6J) or MMP-9 gene knockout (MMP9À/À) mice. Pial venular leakage of fluorescein isothiocyanate-bovine serum albumin to Fg or PBS alone and to topically applied histamine (10 À5 mol/L) were assessed. Intravital fluorescence microscopy and image analysis were used to assess cerebrovascular protein leakage. Pial venular macromolecular leakage increased more after Fg infusion than after infusion of PBS in both (WT and MMP9À/À) mice but was more pronounced in WT compared with MMP9À/À mice. Expression of vascular endothelial cadherin (VE-cadherin) was less and plasmalemmal vesicle-associated protein-1 (PV-1) was greater in Fg-infused than in PBS-infused both mice groups. However, in MMP9À/À mice, VE-cadherin expression was greater and PV-1 expression was less than in WT mice. These data indicate that at higher levels, Fg compromises microvascular integrity through activation of MMP-9 and downregulation of VE-cadherin and upregulation of PV-1. Our results suggest that elevated blood level of Fg could have a significant role in cerebrovascular dysfunction and remodeling.

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Serotonin in the Regulation of Brain Microcirculation

Cited by 271 publications

References 138 publications

The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory

The differential effects of ecstasy/polydrug use on executive components: shifting, inhibition, updating and access to semantic memory

Current and prospective pharmacological targets in relation to antimigraine action

Fibrinogen-Induced Increased Pial Venular Permeability in Mice

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