recreational drug use. We have seen the emergence and rapid growth in the use of a group of psychoactive drugs currently neither controlled Introduction Within the last 12 months, an unexpected and unprecedented shift has occurred in British

Rationale/Objectives: Recent theoretical models suggest that the central executive may not be a unified structure. The present study explored the nature of central executive deficits in ecstasy users. Methods: In Study One, 27 ecstasy users and 34 nonusers were assessed using tasks to tap memory updating (computation span; letter updating) and access to long-term memory (a semantic fluency test and the Chicago word fluency test). In Study Two, 51 ecstasy users and 42 nonusers completed tasks that assess mental set switching (number/letter and plus/minus) and inhibition (random letter generation). Results: MANOVA revealed that ecstasy users performed worse on both tasks used to assess memory updating, and on tasks to assess access to long-term memory (C-and S-letter fluency). However, notwithstanding the significant ecstasy-group related effects, indices of cocaine and cannabis use were also significantly correlated with most of the executive measures. Unexpectedly, in Study Two, ecstasy users performed significantly better on the inhibition task producing more letters than nonusers. No group differences were observed on the switching tasks. Correlations between indices of ecstasy use and number of letters produced were significant. Conclusions: The present study provides further support for ecstasy/polydrug related deficits in memory updating and in access to long-term memory. The surplus evident on the inhibition task should be treated with some caution as this was limited to a single measure and has not been supported by our previous work.

An anonymous self-report survey of drug use among a cohort of 776 14-15 year olds in North-West England was conducted at the end of 1991, aiming to estimate prevalence and profile users. Six in 10 reported being offered drugs, and 36 per cent to using drugs (20 per cent in the past month). Over half of those offered drugs had tried them. Lifetime prevalence was highest for cannabis (32 per cent), with five other drugs each being used by 10-14 per cent. Three groups identified were cannabis smokers, solvents sniffers, and stimulant/psychedelic (or dance drug) users. The population parameters of drug use were estimated at 33-40 per cent, suggesting up to 200,000 local young adults have used drugs. Most significantly, the proportion of young women being offered and using drugs and the prevalence of drug trying amongst young people in 'middle-class' schools, suggests a substantial social transformation is underway in respect of recreational drug use. The results of this survey confirm a general trend apparent in other British studies. As this cohort is tracked into the mid 1990s, the sociological implications will be significant.

Rationale/Objectives: Research has revealed associative learning deficits among users of ecstasy; the present study explored the component processes underlying these deficits. Methods: 35 ecstasy users and 62 non-ecstasy users completed a computerbased, verbal paired-associates learning task. Participants attempted to learn eight sequentially presented word pairs. After all eight had been presented, the first member of each pair was displayed and participants attempted to recall the second. Eight trials were administered. Correct responses on each trial, forgetting at various levels of learning, perseveration errors and the rate at which the associations were learned (trials to completion) were all recorded. Results: MANOVA revealed that ecstasy users performed worse overall and subsequent ANOVAs showed that users performed significantly worse on virtually all measures. Regression analysis revealed that over half of the ecstasy-group related variance in trials to completion was attributable to group differences in initial learning and forgetting. In relation to forgetting, it appears that cannabis use may be an important determinant. In relation to rate of learning (trials to completion) and initial learning, both ecstasy and cannabis may be implicated. Conclusions: There appears to be abundant evidence of associative learning deficits among ecstasy users. However, it appears that a range of illicit drugs including cannabis and ecstasy may contribute to these deficits.

Outbreaks of illicit opioid use have been occurring throughout the U.K. during the 1980's, and Merseyside has been particularly affected. This paper reports on the prevalence of known opioid use in Witral, a metropolitan borough of Merseyside with a population of 339,000 where a heroin 'epidemic' began 5 years ago. Using a multi-agency enumeration technique the annual prevalence of known opioid use during t984-85 was found to be 4.4 per 1000 ofthe adult population, which indicates a rapidity and depth of penetration not previously encountered in the U,K. In contrast to the typically London-based heroin user of the late 196O's and early 197O's, the new heroin users of Wirral are predominantly young, unemployed, and socially deprived. These new users also display a strong preference for smoking heroin. Their profile is compared zvith that found in other recent local surveys of drug misuse.