Serotonin fibre densities in subcortical areas: differential effects of isolated rearing and methamphetamine

Lehmann, Konrad; Lesting, Jörg; Polascheck, Dierk; Teuchert-Noodt, Gertraud

doi:10.1016/s0165-3806(03)00130-5

Cited by 40 publications

(21 citation statements)

References 59 publications

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“…Similarly, increased serotonergic sprouting was observed in gerbil amygdala and hippocampal brain regions following isolation rearing and early methamphetamine administration, both manipulations that decrease dopaminergic innervation of these areas [35]. These adaptive changes were speculated to result from dopaminergic disinhibition of serotonin signaling and subsequent promotion of serotonergic sprouting [35]. Data such as this highlights the difficulty involved in isolating factors responsible for altered neural morphology, due to the combination of neurotransmitter cross-talk and autoregulation.…”

Section: Evidence For Autoregulation Of Morphology By Serotoninmentioning

confidence: 99%

“…However, 5-HT 1B is also expressed in non-serotonergic neurons and the potential for indirect modulation of serotonergic morphology by other neurotransmitters in the region analyzed cannot be excluded. Similarly, increased serotonergic sprouting was observed in gerbil amygdala and hippocampal brain regions following isolation rearing and early methamphetamine administration, both manipulations that decrease dopaminergic innervation of these areas [35]. These adaptive changes were speculated to result from dopaminergic disinhibition of serotonin signaling and subsequent promotion of serotonergic sprouting [35].…”

Section: Evidence For Autoregulation Of Morphology By Serotoninmentioning

confidence: 99%

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Serotonin: a regulator of neuronal morphology and circuitry

Daubert

Condron

2010

Trends in Neurosciences

265

171

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Serotonin is an important neuromodulator associated with a wide range of physiological effects in the central nervous system. The exact mechanisms for how serotonin influences brain development are not well understood, although studies in invertebrate and vertebrate model organisms are beginning to unravel a regulatory role for serotonin in neuronal morphology and circuit formation. Recent data suggests a developmental window during which altered serotonin levels permanently impact circuitry, however, the temporal constraints and molecular mechanisms responsible are still under investigation. Growing evidence suggests that alterations in early serotonin signaling contribute to a number of neurodevelopmental and neuropsychiatric disorders. Thus, understanding how altered serotonin signaling affects neuronal morphology and plasticity, and ultimately animal physiology and pathophysiology, will be of great significance.

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Section: Evidence For Autoregulation Of Morphology By Serotoninmentioning

confidence: 99%

Section: Evidence For Autoregulation Of Morphology By Serotoninmentioning

confidence: 99%

Serotonin: a regulator of neuronal morphology and circuitry

Daubert

Condron

2010

Trends in Neurosciences

265

171

View full text Add to dashboard Cite

show abstract

“…5-HT 1A binding is reduced in prelimbic cortex and increased in motor & somatosensory cortices and dentate gyrus and CA of hippocampus (Preece et al, 2004) Increased 5-HT fibre density in dorsal caudate putamen, NAcc and amygdala in gerbils (Lehmann et al, 2003) Circadian rhythms altered by isolation-5-HT peak later, tryptophan and 5-HIAA earlier (Greco et al, 1989) Noradrenaline Isolation has no effect on basal or K + -induced NA release in hippocampus or hypothalamus (in vitro slices). Idazoxan-induced NA release greater in isolates hippocampus-suggests altered sensitivity of presynaptic a2 autoreceptors (Fulford and Marsden, 1997a) Unaltered basal but enhanced K + -stimulated dorsal hippocampal NA release.…”

Section: Neurotransmittermentioning

confidence: 99%

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Fone

Porkess

2008

Neuroscience & Biobehavioral Reviews

768

590

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“…Most of our knowledge about the mediation of the therapeutic effects of stimulants derives from studies focused on the PFC and striatum, but there is increasing evidence of the relevance of catecholaminergic modulation in limbic regions such as ventral striatum (perhaps also amygdala and hippocampus) in mediating the motivation enhancing effects of stimulant drugs (Lehmann et al, 2003;Wilens, 2008).…”

Section: Neuronal Targets Of Stimulant Medicationsmentioning

confidence: 99%

Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress

Swanson

Baler

Volkow

2010

Neuropsychopharmacol

215

165

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The use of stimulant drugs for the treatment of children with attention-deficit hyperactivity disorder (ADHD) is one of the most widespread pharmacological interventions in child psychiatry and behavioral pediatrics. This treatment is well grounded on controlled studies showing efficacy of low oral doses of methylphenidate and amphetamine in reducing the behavioral symptoms of the disorder as reported by parents and teachers, both for the cognitive (inattention and impulsivity) and noncognitive (hyperactivity) domains. Our main aim is to review the objectively measured cognitive effects that accompany the subjectively assessed clinical responses to stimulant medications. Recently, methods from the cognitive neurosciences have been used to provide information about brain processes that underlie the cognitive deficits of ADHD and the cognitive effects of stimulant medications. We will review some key findings from the recent literature, and then offer interpretations of the progress that has been made over the past decade in understanding the cognitive effects of stimulant medication on individuals with ADHD. Neuropsychopharmacology Reviews (2011) 36, 207-226; doi:10.1038/npp.2010; published online 29 September 2010Keywords: methylphenidate; amphetamine; dopamine; prefrontal cortex; executive function; cognitive enhancement INTRODUCTIONCognitive deficits and behavioral symptoms associated with attention-deficit/hyperactivity disorder (ADHD) have been studied intensively and are well documented in the literature. Stimulant drugs (methylphenidate (MP) and amphetamine (AMP)) are particularly effective for the clinical treatment of ADHD, and accordingly, pediatricians and psychiatrists have been prescribing them for over seven decades (Bradley, 1937). Clear reductions in symptoms justify treatment with stimulant medications (MTA, 1999b), but the cognitive effects are less clear. Here, we will review the current understanding of some underlying neural processes that may account for the ADHD symptoms of inattention and impulsivity, and we will review evidence from neuropsychological and neuroimaging studies about how stimulant medications may affect these processes. To focus our review, we will not revisit related topics that are addressed elsewhere: the medical use of non-stimulant drugs to treat ADHD (Dopheide and Pliszka, 2009;Waxmonsky, 2005), the non-medical use of stimulants and non-stimulants for cognitive enhancement (Sahakian and Morein-Zamir, 2007;Stix, 2009), and nonmedical alternative treatments based on neurofeedback (Gevensleben et al, 2009) and working memory training (Klingberg et al, 2005) that have recently been evaluated and have gained some support in randomized clinical trials.In the Diagnostic and Statistical Manual (DSM) of the American Psychiatric Association, Version IV (APA, 1994(APA, , 2000, the cognitive symptoms of ADHD are grouped into two domains: inattention and hyperactivity/impulsivity. Currently, nine are specified for inattention (poor attending to details, sustaining attention, lis...

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Serotonin fibre densities in subcortical areas: differential effects of isolated rearing and methamphetamine

Cited by 40 publications

References 59 publications

Serotonin: a regulator of neuronal morphology and circuitry

Serotonin: a regulator of neuronal morphology and circuitry

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

Understanding the Effects of Stimulant Medications on Cognition in Individuals with Attention-Deficit Hyperactivity Disorder: A Decade of Progress

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