Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to `binge' cocaine administration

Burchett, Scott A.; Bannon, Michael J.

doi:10.1016/s0169-328x(97)00131-9

Cited by 43 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data on the lack of regulation of DAT protein levels in the NAc are in agreement with other studies, where DAT levels were also not altered following cocaine withdrawal (Kula and Baldessarini, 1991;Claye et al, 1995;Hitri et al, 1996;Burchett and Bannon, 1997;Letchworth et al, 1999;Arroyo et al, 2000). However, there are previous reports that DAT binding is initially increased in the NAc (1-2 days of withdrawal), and then decreased following 7-60 days of withdrawal (Wilson et al, 1994;Kuhar and Pilotte, 1996).…”

Section: Dat and Th Levels In Terminal Daergic Regions Following Withsupporting

confidence: 92%

Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats

Grimm

Shaham²,

Hope³

2002

Behavioural Pharmacology

113

View full text Add to dashboard Cite

Lever pressing during tests for resistance to extinction and cue-induced reinstatement of cocaine seeking in rats progressively increases over the first 2 months of withdrawal. In the present report, we investigated the generality of these findings in rats trained to self-administer sucrose, a non-drug reinforcer. We also examined whether the time-dependent changes in cocaine seeking correlate with the levels of the dopamine transporter (DAT) and tyrosine hydroxylase (TH) proteins in the amygdala, nucleus accumbens, prefrontal cortex and orbitofrontal cortex. Rats were trained to selfadminister cocaine (0.5 mg/kg/i.v. infusion) or 10% sucrose (0.2 ml/infusion into a liquid drop receptacle) for 10 days (6 h/day); each reward delivery was paired with a tone+light cue. Tests for cocaine seeking were conducted following 1 or 15 reward-free days. On the test day, rats were initially tested for resistance to extinction during 6-7 60-min extinction sessions in the absence of the tonelight cue, until they reached the extinction criterion of less than 15 responses/60 min. Subsequently, rats were tested for cue-induced reinstatement during a 60-min session in which each lever press led to a contingent presentation of the tone-light cue. Lever pressing during the tests for reward seeking was significantly greater on day 15 than on day 1 following withdrawal from both cocaine and sucrose self-administration training. The levels of DAT, but not TH, were greater in the prefrontal cortex of cocaine-trained rats than in sucrose-trained rats on both days 1 and 15 of withdrawal. The levels of DAT and TH in other brain areas were not altered following withdrawal from cocaine or sucrose self-administration. These data suggest that the withdrawal period can modulate reward seeking of both drug and non-drug reinforcers, and that alterations in DAT and TH levels in the brain regions examined do not mediate this effect.

show abstract

Section: Dat and Th Levels In Terminal Daergic Regions Following Withsupporting

confidence: 92%

Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats

Grimm

Shaham²,

Hope³

2002

Behavioural Pharmacology

113

View full text Add to dashboard Cite

show abstract

“…Additional data implicate other receptor systems (GABA-A receptor subunits, GABA-B receptor, glutamate receptors, transcription factors, etc.). Complementary to previously published results, we did not observe significant alteration in the D2 dopamine receptor (Moore et al, 1998), dopamine transporter, tyrosine hydroxylase (Sorg et al, 1993;Vrana et al, 1993;Burchett and Bannon, 1997) or in serotonin receptor subytpe 2C or 3 mRNA levels. Additional analyses at the protein level indicated an upregulation of CREB in the VTA, but not in the lateral substantia nigra.…”

Section: Drug Abusesupporting

confidence: 91%

Functional genomics and psychiatric illness

Hasenkamp

Hemby

2002

Progress in Brain Research

View full text Add to dashboard Cite

“…To the extent that impaired inhibition of a previously learned response and the inability to withhold responding in the presence of a discriminative stimulus reflect similar processes, the two studies produced contradictory results. Indeed we were surprised at the minimal behavioural effects that we observed, particularly as similar dosing regimes can produce pronounced neural and behavioural changes (Burchett & Bannon, 1997;Unterwald, Ho, Rubenfield, & Kreek, 1994;). Moreover, cortical serotonergic mechanisms were partially compromised in our study in that the 5-HT receptor antagonist, methiothepin, was more effective in blocking electrocorticogram (ECoG) activity in cocaine-than in saline-treated animals.…”

Section: Chronic Drug Exposurementioning

confidence: 85%

“…In addition, although chronic cocaine does not alter basal levels of cortical 5-HT (Baumann, Raley, Partilla, & Rothman, 1993;Johnson, Fiorella, & Rabin, 1993), it does cause regionally specific alterations in 5-HT uptake binding (Belej, Maji, Sioutis, Barros, & Nobrega, 1996;Burchett & Bannon, 1997;Cunningham, Paris, & Goeders, 1992) and decreased 5-HT turnover rates in the frontal cortex (Dworkin, Co, & Smith, 1995). Most importantly, these changes are dose dependent and many persist long after the cessation of drug use.…”

Section: A Role For Animal Researchmentioning

confidence: 96%

Animal models of drug addiction: Where do we go from here?

Olmstead

2006

Quarterly Journal of Experimental Psychology

View full text Add to dashboard Cite

Compulsion and impulsivity are both primary features of drug addiction. Based on decades of animal research, we have a detailed understanding of the factors (both environmental and physiological) that influence compulsive drug use, but still know relatively little about the impulsive aspects of drug addiction. This review outlines our current knowledge of the relationship between impulsivity and drug addiction, focusing on cognitive and motor impulsivity, which are particularly relevant to this disorder. Topics to be discussed include the influence of chronic drug administration on impulsivity, the mechanisms that may explain drug-induced impulsivity, and the role of individual differences in the development of impulsive drug use. In addition, the manner in which contemporary theories of drug addiction conceptualize the relationship between impulsivity and compulsion is examined. Most importantly, this review emphasizes a critical role for animal research in understanding the role of impulsivity in the development and maintenance of drug addiction.

show abstract

Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to `binge' cocaine administration

Cited by 43 publications

References 37 publications

Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats

Effect of cocaine and sucrose withdrawal period on extinction behavior, cue-induced reinstatement, and protein levels of the dopamine transporter and tyrosine hydroxylase in limbic and cortical areas in rats

Functional genomics and psychiatric illness

Animal models of drug addiction: Where do we go from here?

Contact Info

Product

Resources

About