Serotonin — bradykinin potentiation on the pain receptors in man

Sicuteri, F; Fanciullacci, M; Franchi, G; Bianco, P. L. Del

doi:10.1016/0024-3205(65)90147-5

Cited by 101 publications

(21 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, animal studies have shown increased pain sensitivity with pharmacological and neural lesion depletion of brain serotonin (29)(30)(31). Serotonin is suggested as a peripheral mediator in the pain-producing action of bradykinin and potassium on vascular systems (36). Peripheral serotonergic mechanisms have also been implicated in the induction of pain (35).…”

Section: Nrem Sleep Disturbance and Symptomsmentioning

confidence: 99%

Musculosketal Symptoms and Non-REM Sleep Disturbance in Patients with “Fibrositis Syndrome” and Healthy Subjects

Moldofsky¹,

Scarisbrick²,

England³

et al. 1975

Psychosomatic Medicine

759

115

View full text Add to dashboard Cite

In sleep studies of (a) patients with the "fibrositis syndrome" and (b) healthy subjects undergoing stage 4 sleep deprivation, we observed in both groups the anomalous presence of alpha-rhythms in the non-rapid-eye-movement (NREM) sleep EEG. This phenomenon has been termed alpha-delta sleep. In the healthy subjects stage 4 deprivation was accompanied by the temporary appearance of muscoloskeletal and mood symptoms comparable to the symptoms seen chronically in the patients. It is suggested that the external arousing stimulus, which induced alpha-delta sleep in the subjects, is paralleled in the patients by an internal arousing mechanism. Such a mechanism, acting in competition with the NREM sleep system, would impair the presumed restorative function of NREM sleep and lead to the development of symptoms. It is proposed that the "fibrositis" symptom complex be considered a "non-restorative sleep syndrome". Evidence froms presented in support of the hypothesis that a disorder of serotonin metabolism serves as a basis for both the EEG sleep disturbance and the symptoms.

show abstract

Section: Nrem Sleep Disturbance and Symptomsmentioning

confidence: 99%

Musculosketal Symptoms and Non-REM Sleep Disturbance in Patients with “Fibrositis Syndrome” and Healthy Subjects

Moldofsky¹,

Scarisbrick²,

England³

et al. 1975

Psychosomatic Medicine

759

115

View full text Add to dashboard Cite

show abstract

“…Activation of nociceptors causes immediate, overt pain whereas sensitization of nociceptors is responsible for the development of inflammatory hyperalgesia. Bradykinin was established as a pain mediator because it produced immediate, overt pain in man (Armstrong et al, 1957;Sicuteri et al, 1965;Ferreira, 1972;Whalley et al, 1987). This immediate effect of bradykinin has been the subject of numerous behavioural and electro-physiological studies (Dray et al, 1988;Lang et al, 1990;Handwerker & Reeh, 1991) and appears to result from the activation of the high threshold nociceptors associated with C fibres.…”

Section: Introductionmentioning

confidence: 99%

Bradykinin initiates cytokine‐mediated inflammatory hyperalgesia

Ferreira

Lorenzetti

Poole

1993

British J Pharmacology

259

170

View full text Add to dashboard Cite

“…It is still uncertain, however, the extent to which other inflammatory mediators found in tissue exudates may contribute to the sensitization of peripheral sensory receptor mechanisms. Keele & Armstrong (1964) demonstrated that 5-hydroxytryptamine (5-HT) has the ability to cause pain when applied to a blister base, and 5-HT was later shown to lower thresholds for chemically-induced pain in man (Sicuteri et al, 1965) and to enhance pseudoaffective responses to bradykinin in animals (Nakano & Taira, 1976). Sensory nerve endings associated with small myelinated and non-myelinated axons have been found to be activated and sensitized by 5-HT in ' Author for correspondence.…”

Section: Introductionmentioning

confidence: 99%