The effects of 5‐HT on articular sensory receptors in normal and arthritic rats

Birrell, G.J.; McQueen, Daniel S.; Iggo, A.; Grubb, Blair D.

doi:10.1111/j.1476-5381.1990.tb14146.x

Cited by 37 publications

(15 citation statements)

References 28 publications

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“…The doses of 5-HT injected i.a. in the rat (Birrell et al 1990) were similar to those in our experiments {1-100 p,g vs. 0.135-135 p,g).…”

Section: Discussionsupporting

confidence: 77%

“…The effects of 5-HT on articular sensory receptors have also been investigated in a different species, the rat (Birrell et al 1990), but with another model to induce arthritis (rat adjuvant-induced polyarthritis) and a quite different mode of classifying joint receptors. Adjuvant-induced polyarthritis serves as a model for chronic inflammatory pain (see Colpaert 1987).…”

Section: Discussionmentioning

confidence: 99%

“…Adjuvant-induced polyarthritis serves as a model for chronic inflammatory pain (see Colpaert 1987). Unidentified chemosensitive afferents and hightbreshold mechanoreceptors from rat medial plantar nerve were excited in a fast transient hurst, followed by a delayed slow Ionger-lasting excitation (Birrell et al 1990). These 2 seperate components of 5-HT-induced excitation were · only observed in rat knee joint afferents.…”

Section: Discussionmentioning

confidence: 99%

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Activation of normal and inflamed fine articular afferent units by serotonin

Herbert

Schmidt

1992

Pain

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SummaryIn cats anesthetized with alpha-chloralose, extracellular recordings were made from fine afferent units belonging to the medial articular nerve (MAN) of the knee joint. The excitatory and sensitizing effects on articular afferents of serotonin (5-HT) applied intra-arterially close to the joint were examined. The joints were either normal or an experimental arthritis had been induced some hours before the recording session. Bolus injections of 1.35-135 p,g 5-HT excited about 43% of group 111 (CV: 2.5-20 mjsec) and 73% of group IV units (CV: < 2.5 mjsec) from normal joints. The latency was usually between 10 and 30 sec, and the duration and size of the responses were dose-dependent. Fast group 111 units (CV: > 16 mjsec) and group li units (CV: > 20 mjsec) were never excited by 5-HT. Repetitiveadministration led to pronounced tachyphylaxis of the 5-HT response. Inflammation induced an enhanced sensitivity of group III articular afferent units to close intra-arterial application of 5-HT. In particular the total duration of each response was considerably prolonged (4-10 min against 1-2 min under normal conditions). At the same time the tachyphylaxis seen under normal conditions was gteatly reduced. In contrast, group IV articular afferent units did not become sensitized to 5-HT in the course of inflammation. In normal joints 5-HT did not sensitize fineafferent units for movement-induced responses. However, after inflammation, a distinct sensitization to such movements by 5-HT application could be observed bothin group 111 and group IV fiber ranges. The sensitization had a short time course not exceeding 7 min. The tonic component of the movement-induced response was more enhanced than the phasic one. The bolus application of 5-HT led to temporary vasoconstriction of the knee joint vessels. This vasoconstriction was especially pronounced in inflamed joints and impeded the access of subsequently applied substances to the terminal regions of the afferent units under observation.lt is concluded that the present results support the notion that 5-HT may participate in the mediation of pain from inflamed tissue such as an arthritic joint by exciting and sensitizing fine afferent units. During inflammation group 111 units are particularly sensitive to 5-HT and, thus, may carry the bulk of the 5-HT-induced nociceptive messages.

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“…The doses of 5-HT injected i.a. in the rat (Birrell et al 1990) were similar to those in our experiments {1-100 p,g vs. 0.135-135 p,g).…”

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Activation of normal and inflamed fine articular afferent units by serotonin

Herbert

Schmidt

1992

Pain

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“…For example, 5-HT enhances peripheral sensory sensitivity in a variety of tissues (cf. Birrell et al, 1990) and given its localization to specific cells in taste buds, it is reasonable to hypothesize that this monoamine is a potential neurotransmitter or neuromodulator in peripheral taste organs. Similarly, the effects of adrenalin and noradrenalin on sensory organs, including taste buds, have long been known.…”

mentioning

confidence: 99%

The microphysiology of peripheral taste organs

Roper

1992

J. Neurosci.

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Recent studies on how peripheral taste organs function have revealed a number of intriguing membrane mechanisms underlying taste transduction. The story is still evolving, but certain generalities can now be stated confidently. For example, there is no one single chemosensory membrane transduction event. Instead, the different taste qualities--sweet, sour, salty, bitter--are subserved by different mechanisms. Furthermore, chemical and electrical synaptic processing in the taste bud is likely to modulate the output of the taste organs and may contribute to how different taste qualities are discriminated. Synapses occur between adjacent cells in the taste organ as well as between receptor cells and sensory fibers. The preponderance of data indicates that biogenic amines are present in taste buds and exert some form of neuromodulatory control, if not frank neurotransmission, in peripheral taste organs. Current research in the microphysiology of taste buds includes extending and refining our understanding of how the apical, chemosensitive regions of receptor cells respond to taste stimuli, identifying what synaptic transmitters exist in taste organs, and exploring synaptic mechanisms in taste buds.

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“…It is well established that serotonin (5-hydroxytryptamine, 5-HT) and other mediators of inflammation play an essential role in peripheral mechanisms of pain through participating in sensitization and activation of nociceptors [7,8]. Controlled reduction of the content of 5-HT in inflammatory pain syndromes is used for the development of new analgesic drugs.…”

mentioning

confidence: 99%