Serotonin and proctolin modulate the response of a stretch receptor in crayfish

Manira, Abdeljabbar El; Rossi-Durand, Christiane; Clarac, François

doi:10.1016/0006-8993(91)91091-e

Cited by 28 publications

(16 citation statements)

References 14 publications

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“…To the best of our knowledge, this is the first investigation examining neuromodulation of temporal jitter in a primary sensory neuron. Previous studies of invertebrate mechanoreceptors have shown that neuromodulation can modify neuronal firing properties Bush, 1987, 1989;el Manira et al, 1991;RossiDurand, 1993;Strawn et al, 2000;Birmingham, 2001) including the firing rate (Birmingham et al, 2003), sensitivity (Widmer et al, 2005), kinetics of adaptation (Zhang et al, 1992;Birmingham et al, 2003), tonic versus phasic response, (Ramirez et al, 1993;Matheson, 1997), and even the mode of firing (Combes et al, 1997). In this study, we show for the first time that neuromodulators can also modify the temporal precision of spike trains produced in these neurons.…”

Section: Discussionmentioning

confidence: 67%

“…In the last case serotonin, like AST, decreases the spike rate (Birmingham et al, 2003). In contrast, serotonin increases the static and dynamic response of crustacean chordotonal afferents (el Manira et al, 1991;Rossi-Durand, 1993) in a dosedependent manner and also increases the input resistance of leg motor neurons that receive input from chordotonal afferents (Le Bon-Jego et al, 2004). We repeated the CBCTO experimental protocol described above to test whether serotonin also modified the spike-timing precision.…”

Section: Cbcto Spike Rate and Jitter Increase In Serotoninmentioning

confidence: 99%

See 1 more Smart Citation

Neuromodulation of Spike-Timing Precision in Sensory Neurons

Billimoria

DiCaprio²,

Birmingham³

et al. 2006

J. Neurosci.

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The neuropeptide allatostatin decreases the spike rate in response to time-varying stretches of two different crustacean mechanoreceptors, the gastropyloric receptor 2 in the crab Cancer borealis and the coxobasal chordotonal organ (CBCTO) in the crab Carcinus maenas. In each system, the decrease in firing rate is accompanied by an increase in the timing precision of spikes triggered by discrete temporal features in the stimulus. This was quantified by calculating the standard deviation or "jitter" in the times of individual identified spikes elicited in response to repeated presentations of the stimulus. Conversely, serotonin increases the firing rate but decreases the timing precision of the CBCTO response. Intracellular recordings from the afferents of this receptor demonstrate that allatostatin increases the conductance of the neurons, consistent with its inhibitory action on spike rate, whereas serotonin decreases the overall membrane conductance. We conclude that spike-timing precision of mechanoreceptor afferents in response to dynamic stimulation can be altered by neuromodulators acting directly on the afferent neurons.

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Section: Discussionmentioning

confidence: 67%

Section: Cbcto Spike Rate and Jitter Increase In Serotoninmentioning

confidence: 99%

Neuromodulation of Spike-Timing Precision in Sensory Neurons

Billimoria

DiCaprio²,

Birmingham³

et al. 2006

J. Neurosci.

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“…The decapods have received by far the most extensive investigation, and here, proctolin has been shown to modulate exoskeletal muscles/neuromuscular junctions [213][214][215][216], the cardiac neuromuscular system [98, [217][218][219][220][221][222], the stomatogastric neuromuscular system [92, 103, 204, 223-228], the ventilatory system [229], the neural circuitry controlling the swimmerets [230,231], mechanosensory neurons [232][233][234], and hindgut contractility [235]. In non-decapods, proctolin has been shown to be a potent myomodulator [236,237] and to modulate cardiac output [238].…”

Section: Pigment Dispersing Hormonementioning

confidence: 99%

Crustacean neuropeptides

Christie

Stemmler

Dickinson

2010

Cell. Mol. Life Sci.

192

407

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Crustaceans have long been used for peptide research. For example, the process of neurosecretion was first formally demonstrated in the crustacean X-organ-sinus gland system, and the first fully characterized invertebrate neuropeptide was from a shrimp. Moreover, the crustacean stomatogastric and cardiac nervous systems have long served as models for understanding the general principles governing neural circuit functioning, including modulation by peptides. Here, we review the basic biology of crustacean neuropeptides, discuss methodologies currently driving their discovery, provide an overview of the known families, and summarize recent data on their control of physiology and behavior.

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“…Proctolin facilitates receptor depolarization and hence spike generation, whereas octopamine and serotonin depress receptor firing. In walking limbs of crayfish, both serotonin and proctolin enhance stretch receptor responsiveness (El Manira, Rossi-Durand & Clarac, 1991), as does octopamine when applied to stretch receptors in the wings of locusts (Ramirez & Orchard, 1990). Unlike these cases, modulation of the mechanoreceptor AGR by the octapeptide TNRNFLRFamide involves more than a seemingly straightforward change in sensitivity to mechanostimulation, but leads to a fundamental alteration in the cell's own intrinsic bioelectrical behaviour: a switch from autoactive tonic firing to rhythmic bursting.…”

Section: Discussionmentioning

confidence: 99%