Conditional dendritic oscillators in a lobster mechanoreceptor neurone.

Combes, Denis; Simmers, John; Moulins, Maurice

doi:10.1113/jphysiol.1997.sp021918

Cited by 24 publications

(27 citation statements)

References 38 publications

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“…To the best of our knowledge, this is the first investigation examining neuromodulation of temporal jitter in a primary sensory neuron. Previous studies of invertebrate mechanoreceptors have shown that neuromodulation can modify neuronal firing properties Bush, 1987, 1989;el Manira et al, 1991;RossiDurand, 1993;Strawn et al, 2000;Birmingham, 2001) including the firing rate (Birmingham et al, 2003), sensitivity (Widmer et al, 2005), kinetics of adaptation (Zhang et al, 1992;Birmingham et al, 2003), tonic versus phasic response, (Ramirez et al, 1993;Matheson, 1997), and even the mode of firing (Combes et al, 1997). In this study, we show for the first time that neuromodulators can also modify the temporal precision of spike trains produced in these neurons.…”

Section: Discussionsupporting

confidence: 57%

Neuromodulation of Spike-Timing Precision in Sensory Neurons

Billimoria

DiCaprio²,

Birmingham³

et al. 2006

J. Neurosci.

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The neuropeptide allatostatin decreases the spike rate in response to time-varying stretches of two different crustacean mechanoreceptors, the gastropyloric receptor 2 in the crab Cancer borealis and the coxobasal chordotonal organ (CBCTO) in the crab Carcinus maenas. In each system, the decrease in firing rate is accompanied by an increase in the timing precision of spikes triggered by discrete temporal features in the stimulus. This was quantified by calculating the standard deviation or "jitter" in the times of individual identified spikes elicited in response to repeated presentations of the stimulus. Conversely, serotonin increases the firing rate but decreases the timing precision of the CBCTO response. Intracellular recordings from the afferents of this receptor demonstrate that allatostatin increases the conductance of the neurons, consistent with its inhibitory action on spike rate, whereas serotonin decreases the overall membrane conductance. We conclude that spike-timing precision of mechanoreceptor afferents in response to dynamic stimulation can be altered by neuromodulators acting directly on the afferent neurons.

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Section: Discussionsupporting

confidence: 57%

Neuromodulation of Spike-Timing Precision in Sensory Neurons

Billimoria

DiCaprio²,

Birmingham³

et al. 2006

J. Neurosci.

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“…AGR had previously been characterized in two different crustacean species, the lobster Homarus gammarus (Combes et al, 1999;Combes et al, 1995;Combes et al, 1997;Simmers and Moulins, 1988a;Simmers and Moulins, 1988b) and the spiny lobster Panulirus interruptus (Elson et al, 1994). We now aim at expanding our knowledge about this sensory neuron by examining it in a third crustacean species, Cancer pagurus.…”

Section: Discussionmentioning

confidence: 99%

“…In the isolated nervous system, AGR was usually tonically active with low firing frequencies (2.26±0.98·Hz; N=12). In contrast to the lobsters H. gammarus (Combes et al, 1997) and P. interruptus (Elson et al, 1994), AGR in C. pagurus never showed spontaneous oscillations (N>50 recordings). However, rhythmic bursts could be elicited with focal application of neuropeptide F1 (10 -6 ·mol·l -1 ) to the dendritic region of AGR (N=4; data not shown).…”

Section: Basic Properties Of the Sensory Neuron Agrmentioning

confidence: 99%

“…A proprioceptor that is particularly suited for investigating the effects of sensory feedback on the STG circuits is the anterior gastric receptor (AGR), which was initially described in the crayfish (Larimer and Kennedy, 1966) and then characterized in detail in the European lobster Homarus gammarus (Combes et al, 1995;Combes et al, 1997;Combes et al, 1999;Simmers and Moulins, 1988a;Simmers and Moulins, 1988b) and the spiny lobster Panulirus interruptus (Elson et al, 1994). In both lobster species AGR occurs as a single bipolar cell body in the STG and measures the tension of the muscles responsible for protraction of the medial tooth.…”

Section: Introductionmentioning

confidence: 99%

“…This work thus provides an initial framework for future studies to determine underlying common principles. Proprioceptive input to central pattern generators be oscillatory, depending on neuromodulatory influences on its dendritic compartment (Combes et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Sensory-induced modification of two motor patterns in the crab,Cancer pagurus

Smarandache

Stein

2007

Journal of Experimental Biology

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SUMMARY Sensory input is pervasive among motor networks and continuously adapts motor patterns to changing circumstances. To elucidate common principles of sensorimotor integration, it is beneficial to characterize sensory influences on motor network operation and compare these influences between species. To facilitate such comparison, we have studied the influence of the anterior gastric receptor (AGR) – a proprioceptor that has been characterized in detail in two lobster species – on the pyloric (filtering of food) and gastric mill (chewing of food) motor patterns in the crab Cancer pagurus. AGR has a bipolar cell body in the stomatogastric ganglion; it was activated by tension increase in gastric mill powerstroke muscles. While two spike initiation zones accounted for its spontaneous activity, active membrane properties (sag potentials, spike frequency adaptation) contributed to the AGR response to current injections. When activated, AGR diminished spike activities in two pyloric motor neurons and prolonged the pyloric cycle period. Furthermore, AGR excited gastric mill protractor neurons, inhibited the retractor neuron and evoked phase-independent resetting of the gastric mill rhythm. Repetitive spike trains entrained the rhythm to both longer and shorter cycle periods. All AGR actions seemed to be mediated via at least two premotor projection neurons in the spatially distant commissural ganglia. The response of the gastric mill neurons was independent of AGR firing frequency. Our results suggest that homologous proprioceptors can elicit similar effects on motor patterns while utilizing different mechanisms. This work thus provides an initial framework for future studies to determine underlying common principles.

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