Serotonin Agonist-Induced Decreases in Intermale Aggression Are Dependent on Brain Region and Receptor Subtype

Cologer-Clifford, Athena; Simon, Neal G.; Lu, Shi-fang; Smoluk, S. A.

doi:10.1016/s0091-3057(97)00295-5

Cited by 43 publications

(15 citation statements)

References 53 publications

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“…On the other hand, involvement of the MRN in aggressive behaviors was also suggested in the cat (Koprowska and Romaniuk, 1997) and female rats (de Almeida and Lucion, 1997). It is now recognized that the role of 5-HT on aggressive behaviors may vary depending on brain regions and also types of aggressive behaviors (Mos et al, 1993; Faccidomo et al, 2008; Bannai et al, 2007; de Almeida and Lucion, 1997; Ferris et al, 1999; Cologer-Clifford et al, 1997). Our results indicate that the increased 5-HT release in the brain areas that receive the ascending projections from the DRN can promote the escalation of aggressive behavior.…”

Section: Discussionmentioning

confidence: 99%

GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Takahashi¹,

Shimamoto²,

Boyson³

et al. 2010

J. Neurosci.

101

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The serotonin (5-HT) system in the brain has been studied more than any other neurotransmitter for its role in the neurobiological basis of aggression. However, which mechanisms modulate the 5-HT system to promote escalated aggression is not clear. We here explore the role of GABAergic modulation in the raphé nuclei, from which most 5-HT in the forebrain originates, on escalated aggression in male mice. Pharmacological activation of GABA B , but not GABA A , receptors in the dorsal raphé nucleus (

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Section: Discussionmentioning

confidence: 99%

GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Takahashi¹,

Shimamoto²,

Boyson³

et al. 2010

J. Neurosci.

101

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“…Serotonin (5-HT) has been associated with complex regulatory processes such as anxiety, depression, and impulse control [47][48][49]. An increasing body of data further suggests that the serotonergic system also plays a principal role in the regulation of attack and defense [49][50][51][52][53]. It has been shown that 5-HT exerts an inhibitory influence on defensive forms of aggression through the activation of 5-HT 1A receptors [54,55].…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of the mechanisms of attack and defense among higher brain animals

Nathaniel

Femi²,

Nathaniel

2006

Open Life Sciences

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Many studies have investigated different mechanisms of attack and defense in different species of higher brain animals including cats, rats, rodents, mice, and even in some bird species. However, detailed comparative analysis has not been carried out to understand the major similarities in the mechanisms of attack and defense across the different species of vertebrates. Although there are differences, there are also significant similarities as well, which warrant comparative assessment. By considering ethological ideas associated with the motivational defense system, we investigated the motor patterns of attack and defense in cats and rats, using the "resident-intruder" experimental paradigm. Our results reveal specific similarities and differences in the motor patterns of attack and defense in rats and cats. We discuss comparatively the mechanisms of attack and defense across different species of vertebrates, focusing on motor patterns, neuromodulating factors, brains neural substrates, and circuitry.

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“…The septum has been implicated in aggression in many species including rodents [Albert et al, 1992;Cologer-Clifford et al, 1997], birds [Goodson et al, 1999] and lizards [Coomber et al, 1997;Sakata et al, 2000]. Although we initially hypothesized that E2 would inhibit 5-HT activity thereby allowing the expression of aggression, the finding that higher doses of E2 (such as those found in E2-IMP females) promote 5-HT activity explains discrepancies found in our previous studies.…”

Section: Discussionmentioning

confidence: 65%

Estradiol Modulation of Central Monoamine Activity in Female Mountain Spiny Lizards

Woodley

Matt²,

Moore³

2000

Brain Behav Evol

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Although estradiol (E2) mediates many behaviors in females, relatively little is known about its role in female aggression. Previous studies in female mountain spiny lizards indicated that female aggression is modulated by ovariectomy and sex steroid hormone replacement and that expression of aggressive behavior is accompanied by changes in serotonin activity. This study examines if E2 modulates the activity of serotonin and other central monoamines. Free-living females were caught and housed in the laboratory and received one of 3 treatments: sham surgery (SHAM), ovariectomy plus empty implant (OVEX), or sham surgery plus a long lasting E2 implant (E2-IMP). After 3 weeks of treatment, selected brain areas were examined for levels of monoamines and their metabolites. Changes in monoamine activity were most pronounced in the septum where levels of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and norepinephrine (NE) were higher in E2-IMP females relative to SHAM, and levels of 5-HIAA were higher in OVEX females relative to SHAM. Changes in dopamine (DA) activity were also found, with increased DA concentration and decreased ratio of forebrain:brainstem HVA concentrations in E2-IMP relative to SHAM females. These results suggest that the actions of E2 on aggression might be mediated, in part, by dose-dependent effects on 5-HT activity in the septum.

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Serotonin Agonist-Induced Decreases in Intermale Aggression Are Dependent on Brain Region and Receptor Subtype

Cited by 43 publications

References 53 publications

GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Comparative analysis of the mechanisms of attack and defense among higher brain animals

Estradiol Modulation of Central Monoamine Activity in Female Mountain Spiny Lizards

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Serotonin Agonist-Induced Decreases in Intermale Aggression Are Dependent on Brain Region and Receptor Subtype

Cited by 43 publications

References 53 publications

GABABReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

GABABReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Comparative analysis of the mechanisms of attack and defense among higher brain animals

Estradiol Modulation of Central Monoamine Activity in Female Mountain Spiny Lizards

Contact Info

Product

Resources

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GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice