GABA<sub>B</sub>Receptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Takahashi, Akiyoshi; Shimamoto, Akiko; Boyson, Christopher O.; DeBold, Joseph F.; Miczek, Klaus A.

doi:10.1523/jneurosci.1814-10.2010

Cited by 101 publications

(106 citation statements)

References 75 publications

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“…Serotonin (5-HT) is one of the major neurotransmitters that has crucial role on sleep-wake cycle, motor control, immune system, nociception, behavior and aggression regulation in species ranging from invertebrates to humans. In the CNS, 5-HT derives mainly from the midbrain raphe´ nuclei [20,21] . Since years ago, it has been known that serotonin acts in mood regulation [22] but recently it is identified that the 5-HT has important role in the central control of feeding behavior in mammals and avian species.…”

Section: Serotoninmentioning

confidence: 99%

Central regulation of food intake in mammals and birds: a review

Zendehdel

Hassanpour

2015

Neurotransmitter

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Appetite regulates by a complex system of central and peripheral signals which interact in order to modulate ingestion response. A number of peptides comprise a complex network that regulates feeding behavior in vertebrates. This review is focused on the main neurotransmitters and peptides that influence feeding responses in mammals and birds. On the basis of literature review, there are several evidences that neurotransmitters have different effects on food intake between mammals and birds. Also, central regulation of food intake regulates via different mechanisms in animals. So, the aim of this review was to investigate comparative food-intake regulation mechanisms in mammals and birds.

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Section: Serotoninmentioning

confidence: 99%

Central regulation of food intake in mammals and birds: a review

Zendehdel

Hassanpour

2015

Neurotransmitter

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“…We used an autoreceptor agonist, 8-OH-DPAT, as a pharmacological tool to transiently inhibit 5-HT impulse flow from the DRN (Sprouse and Aghajanian, 1987;Will et al, 2004) during testing for aggressive behavior. As intra-DRN infusion of 8-OH-DPAT has been reported to reduce aggressive and motor behaviors in mice in higher doses (1 mg; Faccidomo et al, 2008), we selected a lower dose, 0.3 mg, so that baseline aggression and motor activity would be preserved, as shown by Takahashi et al (2010b). After drinking water or 1.0 g/kg of alcohol, mice received intra-DRN microinfusions of 0.3 mg CP-154,526 alone, 0.3 mg 8-OH-DPAT alone, a combination of CP-154,526 and 8-OH-DPAT, or vehicle in counterbalanced order and subsequently tests for aggressive behavior commenced.…”

Section: Intra-drn Microinjection Of Crf-r1 Antagonists and 8-oh-dpatmentioning

confidence: 99%

Prevention of Alcohol-Heightened Aggression by CRF-R1 Antagonists in Mice: Critical Role for DRN-PFC Serotonin Pathway

Quadros

Hwa

Shimamoto

et al. 2014

Neuropsychopharmacol

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Alcohol can escalate aggressive behavior in a significant subgroup of rodents, humans, and nonhuman primates. The present study investigated whether blockade of corticotropin-releasing factor receptor type 1 (CRF-R1) could prevent the emergence of alcoholheightened aggression in mice. The serotonin (5-HT) pathway from the dorsal raphe nucleus (DRN) to the medial prefrontal cortex (mPFC) by CRF-R1 was investigated as a possible target for the prevention of alcohol-heightened aggressive behavior. Male CFW mice that reliably exhibited aggressive behaviors after consuming 1 g/kg of alcohol received systemic or intra-DRN administration of CRF-R1 antagonists, CP-154,526 or MTIP, before a confrontation with a male conspecific. Blockade of DRN CRF-R1 receptors with both antagonists significantly reduced only alcohol-heightened aggression, whereas systemic administration reduced both alcohol-heightened and species-typical aggression. Next, a 5-HT1A agonist, 8-OH-DPAT, was coadministered with CP-154,526 into the DRN to temporarily disrupt 5-HT activity. This manipulation abolished the antiaggressive effects of intra-DRN CP-154,526. In the mPFC, in vivo microdialysis revealed that extracellular 5-HT levels were increased in mice that consumed alcohol and were then injected with CP-154,526, both systemically or intra-DRN. Neither alcohol nor CP-154,526 alone affected 5-HT release in the mPFC. The present results suggest the DRN as a critical site for CRF-R1 to modulate alcohol-heightened aggression via action on the serotonergic DRN-PFC pathway.

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“…This means that the amplification effect of GABA B agonist baclofen on aggression is dependent on the activation of serotonin neurons. It should be mentioned that both GABA A and GABA B receptors are expressed in the dorsal raphe nucleus of mice and play a role in the aggression behavior (Takahashi et al, 2010a;2010b). On the other hand, according to the report of Cherek et al (2002), amygdala is one of the brain structures involved in aggression, possibly due to several neurotransmitters such as GABA and serotonin (Cherek et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Î³Aminobutyrate B Receptors in Central Amygdaloid and Medial Amygdaloid Nuclei of Amygdala Modulate Aggression in Male Rats

Taherianfard¹,

Abdolahi²,

Rajaian³

et al. 2012

American Journal of Neuroscience

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Abstract:One neurochemical system most consistently linked with aggression is the GABAergic system. The aim of the present investigation was to examine the effect of injection of baclofen (GABA B agonist) and CGP35348 (GABA B antagonist) in the Central Amygdaloid (CA) and Medial Amygdaloid (MA) nuclei of the amygdala on offensive aggression behavior in the animal model. Sixty six adult male rats weighing 180-200g were used. Cannula was implanted into each ac and or am nuclei of amygdala using stereotaxic method. Each animal received 100 electrical shocks every session. After electrical shock, another rat was placed in the electroshock chamber and the animals were observed for various aggressive behaviors. Data were analyzed by Student's T test and one way ANOVA and Tukey's test as the post-hoc test. Significant level was considered to be p<0.05. It was shown that injection of baclofen into the am nucleus of amygdala led to a significant increase in offensive aggression behavior, whereas baclofen injection into the ac nucleus of amygdala led to a significant decrease in offensive aggression behavior. Injection of CGP35348 into the am nucleus of amygdala caused a significant decrease in aggressive behavior, but its injection into the ac nucleus of amygdala induced a significant increase in offensive aggression behavior. Results indicated that GABA B receptors in the ac and am nuclei of amygdala are possibly involved in the modulation of offensive aggression behavior.

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GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Cited by 101 publications

References 75 publications

Central regulation of food intake in mammals and birds: a review

Central regulation of food intake in mammals and birds: a review

Prevention of Alcohol-Heightened Aggression by CRF-R1 Antagonists in Mice: Critical Role for DRN-PFC Serotonin Pathway

Î³Aminobutyrate B Receptors in Central Amygdaloid and Medial Amygdaloid Nuclei of Amygdala Modulate Aggression in Male Rats

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GABABReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice

Cited by 101 publications

References 75 publications

Central regulation of food intake in mammals and birds: a review

Central regulation of food intake in mammals and birds: a review

Prevention of Alcohol-Heightened Aggression by CRF-R1 Antagonists in Mice: Critical Role for DRN-PFC Serotonin Pathway

Î³Aminobutyrate B Receptors in Central Amygdaloid and Medial Amygdaloid Nuclei of Amygdala Modulate Aggression in Male Rats

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GABA_BReceptor Modulation of Serotonin Neurons in the Dorsal Raphé Nucleus and Escalation of Aggression in Mice