Serotonergic autoreceptor blockade in the reduction of antidepressant latency: personality variables and response to paroxetine and pindolol

Tome, Maria; Cloninger, C. Robert; Watson, James P.; Isaac, Michael T.

doi:10.1016/s0165-0327(97)00030-x

Cited by 91 publications

(40 citation statements)

References 17 publications

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“…This rapid restoration of the sensitivity to electrical stimulation (i.e., relative increase in reward) may be attributable to increased serotonin function in forebrain structures, such as the frontal cortex, the hippocampus and the striatum (e.g., Bel and Artigas 1993;Dreshfield et al 1996Dreshfield et al , 1997Invernizzi et al 1994;Gobert and Millan 1999;Rutter et al 1994). The present data are consistent with the hypothesis that the rapid onset of clinical antidepressant action of SSRIs when combined with pindolol (Bordet et al 1998;Tome et al 1997aTome et al , 1997bZanardi et al 1997Zanardi et al , 1998; however, see Berman et al 1997Berman et al , 1999) is partly attributable to pindolol's 5-HT 1A antagonist properties. Nevertheless, other receptors, such as the 5-HT 1B and ␣-adrenergic receptors, for which pindolol has antagonist and/or partial agonist properties, and other neuromechanisms may also contribute to pindolol's augmentation of SSRI antidepressant effects.…”

Section: Discussionsupporting

confidence: 91%

“…Thus, such a drug combination may have rapid therapeutic effects that may be detectable during the short-lasting drug withdrawal. Second, the combination of a SSRI with pindolol [antagonist at 5-HT 1A , 5-HT 1B , and ␤ -adrenergic receptors (Assie and Koek 1996;Bourin et al 1998;Gobert and Millan 1999;Hoyer and Schoeffter 1991;Newman-Tancredi et al 1998); also reported to act as a partial agonist at 5-HT 1A and ␣ -adrenergic receptors (Clifford et al 1998;Fornal et al 1999aFornal et al , 1999bFornal et al , 1999cGobert and Millan 1999;Palmier 1994a, 1994b)] accelerates the onset of antidepressant action of SSRIs in humans (Bordet et al 1998;Zanardi et al 1997Zanardi et al , 1998, or augments the antidepressant response to SSRIs in terms of both magnitude and duration of the response (Maes et al 1999;Perez et al 1997;Tome and Isaac 1998;for review, see McAskill et al 1998;however, see Berman et al 1997however, see Berman et al , 1999Tome et al 1997aTome et al , 1997b. In the present study, instead of pindolol, which has multiple receptor actions, the relatively selective 5-HT 1A receptor antagonist p-MPPI was used.…”

mentioning

confidence: 99%

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Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats

Harrison

Liem

Markou

2001

Neuropsychopharmacology

158

126

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Cessation of chronic nicotine or amphetamine administration precipitates withdrawal syndromes characterized by affective symptoms, including "diminished interest or pleasure" in rewarding stimuli (i.e., anhedonia) (American Psychiatric Association 1994;Covey et al. 1998;Glassman 1993;Hughes 1992). Interestingly, the symptom of "diminished interest or pleasure" is not only a symptom of drug withdrawal, but also a core symptom of depression and a negative symptom of schizophrenia (American Psychiatric Association 1994;Markou et al. 1998). Brain reward threshold elevation is an operational measure of this symptom because it reflects diminished sensitivity to rewarding electrical stimuli. In rats, withdrawal from drugs of abuse belonging to diverse pharmacological classes, such as nicotine (Epping-Jordan et al. 1998 Watkins et al. 2000b), amphetamine Zacharko 1980a, 1980b;Kokkinidis et al. 1980Kokkinidis et al. , 1986 Barrett 1976, 1980;Lin et al. 1999Lin et al. , 2000Paterson et al. 2000;Wise and Munn 1995), cocaine (Baldo et al. 1999;Kokkinidis and McCarter 1990; Koob 1991, 1992a;Markou et al. 1992) morphine (Schulteis et al. 1994) and ethanol (Schulteis et al. 1995) elevated brain stimulation reward thresholds.In addition to the affective aspects of drug withdrawal reflected in threshold elevations, nicotine, opiate, or ethanol withdrawal also lead to alterations in a set of behaviors termed somatic signs. In the case of nicotine, these somatic signs are primarily gasps, writhes, eye blinks, and ptosis (Epping-Jordan et al. 1998;Hildebrand et al. 1997Hildebrand et al. , 1999Malin et al. 1992). It is unlikely that these somatic signs in the rat reflect the affective component of drug withdrawal. Nevertheless, the study of both threshold elevations and somatic signs permits the investigation of the effects of manipulations on the various aspects of withdrawal.Based on evidence demonstrating the efficacy of serotonergic antidepressant treatments, reduced cerebrospinal fluid levels of serotonin metabolites, endocrine measures reflecting reduced serotonergic neurotransmission and the exacerbation of depressive symptomatology seen after serotonin (5-HT) depletion in depressed individuals, it is hypothesized that reduced serotonergic neurotransmission underlies at least some aspects or some subtypes of non-drug-induced depressions (for reviews, see Caldecott-Hazard et al. 1991; CaldecottHazard and Schneider 1992;Heninger et al. 1996;Markou et al. 1998;Meltzer and Lowy 1988;Willner 1985). The purpose of the present study was to test the hypothesis that reduced serotonergic neurotransmission mediates some of the affective aspects, not only of non-drug-induced depressions, but also of druginduced depressions. Thus, the present study tested the hypothesis that enhancement of serotonergic neurotransmission through acute administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine (Wong et al. 1995) in combination with a relatively selective 5-HT 1A receptor antagonist would alleviate the symptom of "dimin...

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 99%

Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats

Harrison

Liem

Markou

2001

Neuropsychopharmacology

158

126

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“…The character dimension are called self-directedness (SD), cooperativeness (C), and self-transcendence (ST). We administered the 125-item version, which has been used by Cloninger himself and colleagues [21]. …”

Section: Methodsmentioning

confidence: 99%

Stability of Alexithymia and Its Relationships with the ‘Big Five’ Factors, Temperament, Character, and Attachment Style

Picardi

Toni

Caroppo

2005

Psychother Psychosom

123

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Background: Controversy still exists concerning the stability of the alexithymia construct. Also, although alexithymia has been found to be related in a theoretically meaningful way to other personality constructs such as the ‘Big Five’ factors, few studies have investigated its relationship with influential constructs such as temperament and character, and attachment security. Methods: Two hundred twenty-one undergraduate and graduate students were administered the Toronto Alexithymia Scale (TAS-20), the State-Trait Anxiety Inventory (STAI), the Zung Depression Scale (ZDS), the Temperament and Character Inventory (TCI-125), the Big Five Questionnaire (BFQ), and the Experiences in Close Relationships (ECR) questionnaire. After 1 month, 115 participants completed again the TAS-20, STAI, and ZDS. Results: Alexithymia was only moderately correlated with depression and anxiety. Both the absolute and relative stability of TAS-20 total and subscale scores was high, and a negligible portion of their change over time was accounted for by changes in depression or anxiety. In separate multiple regression models including also gender, age, depression and anxiety, TAS-20 total and subscale scores were correlated with low energy/extraversion, low emotional stability, openness, low friendliness/agreeableness; harm avoidance, low self-directedness, low cooperativeness, low reward dependence; attachment-related avoidance and anxiety. Conclusions: Our findings lend support for both absolute and relative stability of alexithymia, corroborate an association between alexithymia and insecure attachment, and contribute to a coherent placing of alexithymia in the broader theoretical network of personality constructs.

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“…High RD scores correlate with a better outcome in the treatment with paroxetine and pindolol at 6 weeks and 6 months [25]. Low levels of RD represent an independent predictor for alexithymia [26].…”

Section: Introductionmentioning

confidence: 90%

Combining the Rorschach Test and the Temperament Character Inventory: A New Perspective on Personality Assessment

Fassino¹,

Amianto²,

Levi³

et al. 2003

Psychopathology

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Background: The numerous reports on research involving the clinical assessment of personality in axis I disorders highlight the importance of temperament features in the current approach to all mental disorders. However, the available instruments of personality assessment have many limits. Self-administered questionnaires depend on the patient’s insight, and projective instruments (i.e. the Rorschach test) often lack objectivity. This study compared the results of personality assessment with the Temperament and Character Inventory (TCI) and the Rorschach test to verify their validity. Patients and Methods: TCI and Rorschach tests were administered to a wide sample of patients (n = 180) in a short period. The most common Rorschach siglatures were correlated with the TCI raw scores using the Pearson correlation test. Results: All TCI temperament dimensions and facets displayed at least two correlations with Rorschach siglatures. The description of each dimension and facet of the TCI obtained with the interpretation of Rorschach siglatures was consistent with its original meaning. Conclusions: The TCI and Rorschach tests adequately validated each other. In the future, the administration and integration of these tests will overcome the biases of both. Further, the theoretical bases of the TCI could facilitate the study of psychological functions, whereas the psychodynamic bases of the Rorschach test provide an in-depth insight into temperament traits.

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Serotonergic autoreceptor blockade in the reduction of antidepressant latency: personality variables and response to paroxetine and pindolol

Cited by 91 publications

References 17 publications

Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats

Fluoxetine Combined with a Serotonin-1A Receptor Antagonist Reversed Reward Deficits Observed during Nicotine and Amphetamine Withdrawal in Rats

Stability of Alexithymia and Its Relationships with the ‘Big Five’ Factors, Temperament, Character, and Attachment Style

Combining the Rorschach Test and the Temperament Character Inventory: A New Perspective on Personality Assessment

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