Seroprevalence of Toxoplasma gondii in horses: A global systematic review and meta-analysis

Li, Xi; Ni, Hong-Bo; Ren, Wei-Xin; Jiang, Jing; Gong, Qing‐Long; Zhang, Xiaoxuan

doi:10.1016/j.actatropica.2019.105222

Cited by 52 publications

(30 citation statements)

References 39 publications

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“…Therefore, the local peoples should pay attention to the soil and environment polluted with Toxoplasma oocysts. Furthermore, the current ELISA test based on rTgSAG2 found a slightly lower seroprevalence of T. gondii in horses (13.1%, 8/61) than the average seroprevalence of T. gondii infection (18.0%, 615/3413) in China [35]. Although this study was limited to the number of the horse samples, the high prevalence suggests the horses should not ingest food and water that is probably contaminated by the oocysts of T. gondii that might reduce the seroprevalence.…”

Section: Discussionmentioning

confidence: 74%

“…The current study was the first report for the seroprevalence and epidemiology of T. gondii in chickens, pigs and horses in the Qinghai, though these animals infected with T. gondii have been investigated in other province in China [25,34,35]. Of the investigated animal species in this study, the most prevalent animal for T. gondii infections was the pig, for which seroprevalence was significantly higher than other animals.…”

Section: Discussionmentioning

confidence: 80%

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Seroprevalence and Epidemiology of Toxoplasma gondii in Animals in the Qinghai-Tibetan Plateau Area, China

Zheng

Yang

et al. 2021

Pathogens

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Toxoplasma gondii belongs to the Apicomplexan protozoa—an obligate intracellular parasite—causing toxoplasmosis that has a worldwide distribution and is very harmful to both human health and the livestock industry. However, the information on toxoplasmosis in the Qinghai-Tibetan Plateau Area (QTPA) and the seroprevalence of T. gondii in the food-borne animals in that area has been limited. Therefore, this study focused to T. gondii and toxoplasmosis to perform an indirect ELISA test based on recombinant TgSAG2 protein to establish a comprehensive record of the seroprevalence of T. gondii infections in a wide range of animals, including Tibetan sheep (Ovis aries), yaks (Bos grunniens), cows, chicken, pigs, and horses, in the QTPA. Overall, the seropositive rates of the specific-T. gondii IgG and IgM antibodies in all investigated animals were 44.1% (1179/2673) and 18.0% (469/2612), respectively. The 14.9% (389/2612) sera were determined to be both IgG and IgM positive samples, 30.2% (789/2673) were single-IgG seropositive, and a total of 80 in 2612 animals (3.0%) were single-IgM seropositive. Moreover, for the animal species, the pig was the most prevalent animal (90.2%, 304/337) for IgG positivity, followed by Tibetan sheep (50.7%, 460/907), chickens (45.8%, 229/500), yaks (21.1%, 140/663), cows (18.5%, 38/205) and horses (13.1%, 8/61), respectively. For the IgM antibody positivity, the pig was also the most prevalent animal (41.8%, 141/337), followed by Tibetan sheep (21.2%, 191/907), cows (15.1%, 31/205), chickens (12.4%, 62/500) and yaks (6.6%, 44/663), respectively. The significant differences in the prevalent distribution of T. gondii were found in the different altitudes. In conclusion, this study found the high seroprevalence for T. gondii infections among these animal species in the QTPA, and provides new data to facilitate further research for development of control measures against T. gondii infections in the surveyed locations.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 80%

Seroprevalence and Epidemiology of Toxoplasma gondii in Animals in the Qinghai-Tibetan Plateau Area, China

Zheng

Yang

et al. 2021

Pathogens

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“…The high exposure to both parasites may be the result of the poor sanitation associated with low-income populations, which may increase the chance of exposure to oocysts in water sources or the environment. The association between low income and higher exposure to T. gondii has been previously described in humans and in horses [ 7 , 37 , 38 ]. In addition, in poor sanitary conditions, stray dogs and cats may have access to and feed on donkey carcasses, thus enhancing the maintenance and transmission of Neosporosis and Toxoplasmosis in these areas.…”

Section: Discussionmentioning

confidence: 97%

“…The seroprevalence of T. gondii in horses varies between countries and ranges between 1.2% in Sweden [ 39 ] and 71.2% in Iran [ 40 ]. The differences in prevalence may be associated with housing, stable hygiene and feeding practices [ 7 , 41 ]. The prevalence of T. gondii was higher in donkeys (72.7%) than in horses (27.7%) in a recent study from Brazil [ 42 ], as well as in other studies from Spain [ 23 ] and Pakistan [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical significance of T. gondii infection in horses is unclear. Nevertheless, horses may be exposed to or infected by the T. gondii parasite with no apparent clinical signs, and may pose a zoonotic risk through the consumption of infective horse or donkey meat [ 5 , 6 , 7 ]. In Israel, the seroprevalence of T. gondii was evaluated as 20–60% in humans [ 8 ], 25% in sheep [ 9 ], 36% in dogs [ 10 ], 17% in cats [ 11 ], 43% in crows, 40% in Griffon vultures [ 12 ] and 2.5% in horses [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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High Exposure to Toxoplasma gondii and Neospora Spp. in Donkeys in Israel: Serological Survey and Case Reports

Tirosh-Levy

Steinman

Minderigiu

et al. 2020

Animals

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Toxoplasma gondii and Neospora spp. are closely related cyst-forming coccidian parasites, which infect various animal species and have considerable zoonotic and economic implications, respectively. Both parasites are endemic in Israel and have been reported to infect wild and domestic animals. This study was conceived to evaluate the serologic exposure of donkeys to these parasites. Serum samples were collected from 98 donkeys. Half of them (n = 49) were from animal shelters in Israel, and the rest (n = 49) were working donkeys from the Palestinian Authority. The donkeys were screened for the presence of anti-Toxoplasma and anti-Neospora antibodies by immunofluorescence antibody tests (IFATs). The seroprevalence of T. gondii and Neospora spp. was 94% and 70%, respectively, and 69% of the donkeys were exposed to both parasites. In addition, N. caninum tissue cysts were documented in two donkeys during post-mortem examination. This is the first report of the exposure of donkeys to T. gondii and Neospora spp. in the area. The high prevalence found in this study suggests that donkeys may have a role in the maintenance of these parasites in the area, thus serving as a source of infection for the definitive hosts.

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Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

et al. 2022

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This study aimed to map systemic alterations predisposing to oral squamous cell carcinoma (OSCC) onset. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses. Five databases were used to access (1) reports of OSCC co‐occurring in patients with systemic conditions, (2) prevalence of OSCC among these patients, and (3) clinicopathological profiles. Data from more than 1 million patients worldwide showed that Fanconi's anemia, xeroderma pigmentosum, dyskeratosis congenital, chronic fatigue syndrome, and patients post bone marrow transplantation (BMT) present increased risk for OSCC development. The overall prevalence of OSCC in syndromic patients and post‐BMT were 0.65% (95% CI = 0.13–3.11, p < 0.01) and 5.83% (95% CI = 0.00–30.90, p < 0.01), respectively. The certainty of the evidence was moderate. This study demonstrated that some systemic conditions predispose to OSCC. These results present an impact on the screening of OSCC in systemically compromised patients.

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Seroprevalence of Toxoplasma gondii in horses: A global systematic review and meta-analysis

Cited by 52 publications

References 39 publications

Seroprevalence and Epidemiology of Toxoplasma gondii in Animals in the Qinghai-Tibetan Plateau Area, China

Seroprevalence and Epidemiology of Toxoplasma gondii in Animals in the Qinghai-Tibetan Plateau Area, China

High Exposure to Toxoplasma gondii and Neospora Spp. in Donkeys in Israel: Serological Survey and Case Reports

Systemic conditions associated with increased risk to develop oral squamous cell carcinoma: Systematic review and meta‐analysis

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