Seroprevalence of Toxoplasma among HIV infected and HIV non-infected individuals in North India

Uppal, Beena; Aggarwal, Praveen; Perween, Naz; Sud, Anuj

doi:10.1016/s2222-1808(15)60848-9

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…9,25 Female gender and Toxoplasma seropositivity was found to be associated significantly by Tegegne et al 26 But both the findings are in discordance with the present study where we find that gender is not significantly associated with higher seroprevalence of Toxoplasma gondii and this finding of present study is in concordance with finding of Perween et al Northern India, Mathew from Southern India. 5,13 Various international studies in concordance with present finding are Mahdavi et al, Cademartori et al, Ogoina et al in their study in Northern Nigeria, Muluye et al in their cross-sectional study in Gondar university hospital Northwest Ethiopia, Aliaghi et al in their study on HIV infected subjects in Tehran, Iran, Vasmehjani et al from Jahrom of Southern Iran. 8,15,17,19,20,22…”

Section: Association Of Toxoplasma Seropositivity and Antiretroviral ...supporting

confidence: 84%

“…In contrast, low seroprevalence of 10.8%, 12%, 15% and 21% were found by Amuta et al, Malla et al, Sucilathangam et al and Perween et al respectively. [10][11][12][13] Walle et al found seroprevalence of Toxoplasmosis to be as high as 87.4%. 14 Cademartori et al in 2009-2010 also found 80% prevalence of Toxoplasma seropositivity in Brazil.…”

Section: It Has Been Calculated From Results Of Qualitative Anti-mentioning

confidence: 99%

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Seroprevalence of Toxoplasma gondii in HIV infected cases and its association with CD4 count in Silchar medical college and hospital

Bhattacharjee,

Dhar Chanda

2023

Int J Res Med Sci

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Background: Toxoplasmosis caused by the intracellular coccidian parasite Toxoplasma gondii is one the most common AIDS defining condition in HIV infection. It may produce fatal consequences if gains upper hand in immunocompromised states like HIV infection or due to reactivation of latent disease or new infection. Toxoplasma encephalitis, affecting 15-40% of world’s PLHIV, is the most common opportunistic parasitic co-morbidity conventionally when CD4 count falls below 200/µl. But there has also been reports of asymptomatic toxoplasma IgG seropositivity in PLHIV with CD4 count in the range of 200-500/µl. This study was carried out to find the prevalence of Toxoplasma IgG seropositivity and to determine the association of Toxoplasma gondii seropositivity with CD4 count in HIV infected cases in south Assam. Methods: The 200 HIV infected cases with CD4 count <500/µl attending ICTC, ART centre and various clinical departments were screened by Toxoplasma IgG ELISA over 1 year. Result: It was found that 94 HIV infected cases were seropositive for Toxoplasma IgG and in which CD4 count was significantly less than 200/µl in 54% cases and in the range of 200-500/µl in remaining 46% cases. Conclusions: This sero-surveillance revealed anti-Toxoplasma gondii IgG in 47% cases. IgG seropositivity was significantly higher in cases on ART and in females with history of first trimester abortion. The finding of this study calls for initiation of prophylaxis against Toxoplasma routinely even in HIV cases of this region with CD4count in 200-500/µl range as quite good proportion of Toxoplasma seropositive HIV cases have CD4 count in this range apart from the conventionally vulnerable group with CD4 count below 200/µl.

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Section: Association Of Toxoplasma Seropositivity and Antiretroviral ...supporting

confidence: 84%

Section: It Has Been Calculated From Results Of Qualitative Anti-mentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii in HIV infected cases and its association with CD4 count in Silchar medical college and hospital

Bhattacharjee,

Dhar Chanda

2023

Int J Res Med Sci

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“…In fact, higher prevalence of T. gondii infection in HIV/AIDS patients has been reported in many countries, such as Nigeria, Mali, Ethopia, India, China, and Thailand (Maiga et al, 2001 ; Wanachiwanawin et al, 2001 ; Akanmu et al, 2010 ; Daryani et al, 2011 ; Uppal et al, 2015 ; Shen et al, 2016 ). The present study provided robust evidence that support the conclusion, and demonstrated that HIV/AIDS patients are associated risk factors ( OR = 1.92, 95% CI 1.44–2.55) for T. gondii infection.…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Wang¹,

Liu

Ma³

et al. 2017

Front. Microbiol.

186

190

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Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible studies were included. The estimated pooled prevalence of T. gondii infection in immunocompromised patients and the control was 35.9 and 24.7% (p < 0.001), with an OR of 2.24, i.e., 42.1 and 32.0% for HIV/AIDS patients and the control (p < 0.05), 26.0 and 12.1% for cancer patients and the control (p < 0.001), and 42.1 and 34.5% for transplant recipients and the control (p > 0.05), whose estimated pooled ORs were 1.92 (95% CI, 1.44–2.55), 2.89 (95% CI, 2.36–3.55), and 1.51 (95% CI, 1.16–1.95), respectively. This study is the first to demonstrate that the immunocompromised patients are associated with higher odds of T. gondii infection, and appropriate prevention and control measures are highly recommended for these susceptible populations.

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Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis

et al. 2017

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Seroprevalence of Toxoplasma among HIV infected and HIV non-infected individuals in North India

Cited by 3 publications

References 12 publications

Seroprevalence of Toxoplasma gondii in HIV infected cases and its association with CD4 count in Silchar medical college and hospital

Seroprevalence of Toxoplasma gondii in HIV infected cases and its association with CD4 count in Silchar medical college and hospital

Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis

Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis

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