Seroprevalence of Toscana virus in dogs from Kabylia (Algeria)

Tahir, Djamel; Alwassouf, Sulaf; Loudahi, Abdelghani; Davoust, Bernard; Charrel, Rémi N.

doi:10.1016/j.cmi.2015.10.029

Cited by 19 publications

(18 citation statements)

References 7 publications

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“…The largest amount of data available on dogs, at the outset of this study, concerned TOSV, which observed rates (4.4% in Greece and 8.4% in Cyprus) are in the same order of magnitude as those recently reported in dogs in Tunisia (6.8%, [20]), in Algeria (4.3%, [18]), in France (3.9%, [21]) and in Portugal (6.8% [31]. Because all these studies measured neutralising antibodies against TOSV, their results are comparable and they reflect local circulation of TOSV only, not other viruses belonging to the SFNV complex.…”

Section: Discussionsupporting

confidence: 52%

“…Since collecting human sera displaying a large geographic distribution was challenging, we decided to use dog sera; indeed, dog sera can be good surrogates for the following reasons: (i) dogs are readily infected with phlebotomine-borne phleboviruses which are human pathogens [18, 20, 31, 32]; (ii) domestic dogs live in close contact with humans and therefore are exposed to sandfly bites, although different feeding preferences of sand fly species have to be considered [31]. …”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, all studies performed in Greece and Cyprus used either ELISA or IFA tests, which are notoriously prone to cross-reactivity between viruses belonging to the same serocomplex [7–10]. To conduct our nation-wide (mainland Greece, Greek islands, Cyprus) seroprevalence study in dogs, we selected neutralisation tests which is the most discriminant assay as previously reported in Algeria, Tunisia, Turkey and Portugal [15, 18–20]. Although virus exposure to viruses may be quantitatively different in humans and dogs, because of different feeding preferences of phlebotomines, recent studies suggest that virus circulation can be estimated using either human or dog sera since dogs live in close proximity to humans and are readily infected by these viruses [15, 18, 20, 21].…”

Section: Introductionmentioning

confidence: 99%

“…To conduct our nation-wide (mainland Greece, Greek islands, Cyprus) seroprevalence study in dogs, we selected neutralisation tests which is the most discriminant assay as previously reported in Algeria, Tunisia, Turkey and Portugal [15, 18–20]. Although virus exposure to viruses may be quantitatively different in humans and dogs, because of different feeding preferences of phlebotomines, recent studies suggest that virus circulation can be estimated using either human or dog sera since dogs live in close proximity to humans and are readily infected by these viruses [15, 18, 20, 21]. In our study, dog sera were tested for the presence of neutralising antibodies against TOSV, SFSV, and two viruses belonging to the Salehabad complex (Arbia virus isolated in Italy and Adana virus isolated in Turkey).…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Alwassouf

Christodoulou²,

Bichaud

et al. 2016

PLoS Negl Trop Dis

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Phleboviruses transmitted by sandflies are endemic in the Mediterranean area. The last decade has witnessed the description of an accumulating number of novel viruses. Although, the risk of exposure of vertebrates is globally assessed, detailed geographic knowledge is poor even in Greece and Cyprus where sandfly fever has been recognized for a long time and repeatedly. A total of 1,250 dogs from mainland Greece and Greek archipelago on one hand and 422 dogs from Cyprus on the other hand have been sampled and tested for neutralising antibodies against Toscana virus (TOSV), Sandfly fever Sicilian virus (SFSV), Arbia virus, and Adana virus i.e. four viruses belonging to the 3 sandfly-borne serocomplexes known to circulate actively in the Mediterranean area. Our results showed that (i) SFSV is highly prevalent with 71.9% (50.7–84.9% depending on the region) in Greece and 60.2% (40.0–72.6%) in Cyprus; (ii) TOSV ranked second with 4.4% (0–15.4%) in Greece and 8.4% (0–11.4%) in Cyprus; (iii) Salehabad viruses (Arbia and Adana) displayed also substantial prevalence rates in both countries with values ranging from 0–22.6% depending on the region and on the virus strain used in the test. These results demonstrate that circulation of viruses transmitted by sand flies can be estimated qualitatively using dog sera. As reported in other regions of the Mediterranean, these results indicate that it is time to shift these viruses from the "neglected" status to the "priority" status in order to stimulate studies aiming at defining and quantifying their medical and veterinary importance and possible public health impact. Specifically, viruses belonging to the Sandfly fever Sicilian complex should be given careful consideration. This calls for implementation of direct and indirect diagnosis in National reference centers and in hospital microbiology laboratories and systematic testing of unelucidated febrile illness and central and peripheral nervous system febrile manifestations.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Alwassouf

Christodoulou²,

Bichaud

et al. 2016

PLoS Negl Trop Dis

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“…In addition, Alcube, Arrabida and Massilia viruses have been isolated from phlebotomine sand flies collected in the southwest of Portugal [13, 14]. Although no animal reservoir hosts of these viruses have been identified yet, recent data showed that domestic animals are frequently exposed to them [15–20]. Seroprevalence rates up to 6.8% for TOSV and up to 50.8% for SFSV were recently described in dogs from Portugal [21].…”

Section: Introductionmentioning

confidence: 99%

Serological association between Leishmania infantum and sand fly fever Sicilian (but not Toscana) virus in sheltered dogs from southern Portugal

et al. 2017

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BackgroundPhlebotomine sand fly-borne diseases such as leishmanioses and phleboviruses are emerging threats to animal and public health. Canine leishmaniosis caused by Leishmania infantum is an endemic zoonosis in Portugal. Antibodies to Toscana virus (TOSV) and sand fly fever Sicilian virus (SFSV) were also reported in dogs from the south of the country. The aim of this work was to evaluate a possible association between exposure to L. infantum, TOSV and SFSV in sheltered dogs from the south of Portugal.ResultsSeventy-six (13.1%) out of 581 dogs were seropositive for L. infantum, 327 (56.3%) for SFSV and 36 (6.2%) for TOSV. Six dogs were co-exposed with L. infantum and TOSV, 51 with L. infantum and SFSV and 25 with TOSV and SFSV. One dog had antibodies to the three pathogens. Leishmania infantum seroprevalence was significantly higher in pure breed dogs than in mongrels and in dogs with clinical signs while SFSV positivity was significantly higher in males, in pure and cross-breed dogs than in mongrels and in those not treated with insecticides. Seroprevalence for both viruses was significantly higher in dogs over than 7 years-old than in those aged 1–7. A significant association was observed between the presence of antibodies to L. infantum and SFSV.ConclusionsThe presence of antibodies to several phlebotomine sand fly-borne pathogens in dogs, reinforces the need to implement efficient prophylactic measures to prevent infection among vertebrate hosts including humans. The results also indicate that dogs are good sentinels for assessing human exposure to TOSV and SFSV. Further studies must be performed to elucidate the role of dogs in the dynamics of transmission and if they can play a role as amplifying or reservoir hosts in the natural cycle of these viruses. Public and animal health impacts of these phleboviruses in Portugal should be addressed via serological and virological studies on both phlebotomine sand flies and vertebrate hosts, especially on humans.

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Surveillance of Arthropod-Borne Viruses and Their Vectors in the Mediterranean and Black Sea Regions Within the MediLabSecure Network

et al. 2017

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Purpose of ReviewArboviruses, viruses transmitted by arthropods such as mosquitoes, ticks, sandflies, and fleas are a significant threat to public health because of their epidemic and zoonotic potential. The geographical distribution of mosquito-borne diseases such as West Nile (WN), Rift Valley fever (RVF), Dengue, Chikungunya, and Zika has expanded over the last decades. Countries of the Mediterranean and Black Sea regions are not spared. Outbreaks of WN are repeatedly reported in the Mediterranean basin. Human cases of RVF were reported at the southern borders of the Maghreb region. For this reason, establishing the basis for the research to understand the potential for the future emergence of these and other arboviruses and their expansion into new geographic areas became a public health priority. In this context, the European network “MediLabSecure” gathering laboratories in 19 non-EU countries from the Mediterranean and Black Sea regions seeks to improve the surveillance (of animals, humans, and vectors) by reinforcing capacity building and harmonizing national surveillance systems to address this important human and veterinary health issue. The aim of this review is to give an exhaustive overview of arboviruses and their vectors in the region.Recent FindingsThe data presented underline the importance of surveillance in the implementation of more adapted control strategies to combat vector-borne diseases. Partner laboratories within the MediLabSecure network present a wide range of infrastructures and have benefited from different training programs.SummaryAlthough reporting of arboviral presence is not carried out in a systematic manner, the expansion of the area where arboviruses are present cannot be disputed. This reinforces the need for increasing surveillance capacity building in this region to prevent future emergences.

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Seroprevalence of Toscana virus in dogs from Kabylia (Algeria)

Abstract: International audienceno abstrac

Cited by 19 publications

References 7 publications

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Seroprevalence of Sandfly‐Borne Phleboviruses Belonging to Three Serocomplexes (Sandfly fever Naples, Sandfly fever Sicilian and Salehabad) in Dogs from Greece and Cyprus Using Neutralization Test

Serological association between Leishmania infantum and sand fly fever Sicilian (but not Toscana) virus in sheltered dogs from southern Portugal

Surveillance of Arthropod-Borne Viruses and Their Vectors in the Mediterranean and Black Sea Regions Within the MediLabSecure Network

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