Seroprevalence of Pertussis in Senegal: A Prospective Study

Gaayeb, Lobna; Sarr, Joseph; Ndiath, Mamadou Ousmane; Hanon, Jean-Baptiste; Debrie, Anne-Sophie; Seck, Modou; Schacht, Anne‐Marie; Remoué, Franck; Hermann, Emmanuel; Riveau, Gilles

doi:10.1371/journal.pone.0048684

Cited by 15 publications

(18 citation statements)

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“…26 The area is located in a dry savannah with a dry season from November to June and a short rainy season from July to October. 26, 27 In this region, malaria due to P. falciparum shows a low and seasonal incidence, where peaks of infections appear after the rainy season. 28 Anopheles gambiae s.l.…”

Section: Methodsmentioning

confidence: 99%

Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases

et al. 2017

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The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to α-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying α-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with α-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without α-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-α-Gal antibody protective response. These results have implications for disease control and prevention.

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Section: Methodsmentioning

confidence: 99%

Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases

et al. 2017

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“…The studied majority of the population belongs to the Peulh ethnic group. This region is a dry savannah, with a dry season from November to June and a short rainy season from July to October (annual rainfall <400 mm in 2009) [34]. In this region, malaria transmission is very low, seasonal and mainly due to An.…”

Section: Methodsmentioning

confidence: 99%

gSG6-P1 salivary biomarker discriminates micro-geographical heterogeneity of human exposure to Anopheles bites in low and seasonal malaria areas

et al. 2013

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BackgroundOver the past decade, a sharp decline of malaria burden has been observed in several countries. Consequently, the conventional entomological methods have become insufficiently sensitive and probably under-estimate micro-geographical heterogeneity of exposure and subsequent risk of malaria transmission. In this study, we investigated whether the human antibody (Ab) response to Anopheles salivary gSG6-P1 peptide, known as a biomarker of Anopheles exposure, could be a sensitive and reliable tool for discriminating human exposure to Anopheles bites in area of low and seasonal malaria transmission.MethodsA multi-disciplinary survey was performed in Northern Senegal where An. gambiae s.l. is the main malaria vector. Human IgG Ab response to gSG6-P1 salivary peptide was compared according to the season and villages in children from five villages in the middle Senegal River valley, known as a low malaria transmission area.ResultsIgG levels to gSG6-P1 varied considerably according to the villages, discriminating the heterogeneity of Anopheles exposure between villages. Significant increase of IgG levels to gSG6-P1 was observed during the peak of exposure to Anopheles bites, and decreased immediately after the end of the exposure season. In addition, differences in the season-dependent specific IgG levels between villages were observed after the implementation of Long-Lasting Insecticidal Nets by The National Malaria Control Program in this area.ConclusionThe gSG6-P1 salivary peptide seems to be a reliable tool to discriminate the micro-geographical heterogeneity of human exposure to Anopheles bites in areas of very low and seasonal malaria transmission. A biomarker such as this could also be used to monitor and evaluate the possible heterogeneous effectiveness of operational vector control programs in low-exposure areas.

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“…In contrast, few data are available from Latin American, Asian, and African countries compared with Europe and the United States (174,(439)(440)(441)(442)(443)(444)(445)(446). In the United States, reported outbreaks that have been investigated by local and state health departments have affected diverse populations, including school children, military personnel, and hospitalized patients (245,(446)(447)(448)(449)(450)(451)(452)(453).…”

Section: Control Measures For Pertussis Outbreaksmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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Seroprevalence of Pertussis in Senegal: A Prospective Study

Cited by 15 publications

References 28 publications

Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases

Effect of blood type on anti-α-Gal immunity and the incidence of infectious diseases

gSG6-P1 salivary biomarker discriminates micro-geographical heterogeneity of human exposure to Anopheles bites in low and seasonal malaria areas

Pertussis: Microbiology, Disease, Treatment, and Prevention

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