Seroprevalence of parvovirus B19 IgG and IgM antibodies among pregnant women in Oyo State, Nigeria

Iyanda, Abiodun; Opaleye, Oluyinka Oladele; Ojurongbe, Olusola; Fagbami, A.H.

doi:10.3855/jidc.3157

Cited by 17 publications

(27 citation statements)

References 20 publications

(16 reference statements)

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“…IgM was positive in 3.3% of our study population; it indicates that acute HPV B19 infection is prevalent in our population. It is compatible with a previous study that showed an active transmission of the virus in the community (2). A similar study showed that a significant percentage of child-bearing women were at risk of primary infection which could adversely affect their pregnancy (18).…”

Section: Discussionsupporting

confidence: 80%

“…B19 IgG seroprevalence was 61.4%, with one subject positive for IgM in Sudan (15). In another study, of the 231 women in Nigeria, 45 (20%) were positive for parvovirus B19 IgG, 10 (4%) were positive for parvovirus B19 IgM (2). Also, seroprevalence of HPV B19 in 404 Tunisian pregnant women was 76.2% (16).…”

Section: Discussionmentioning

confidence: 99%

“…The risk of infection compared with nulliparous women increases about several times in women with three or more children. Serious medical conditions and stressful jobs have been shown to be risk factors (2). The risk of exposure is common as HPV B19 circulates widely in the population, particularly in day care centers and schools.…”

Section: Introductionmentioning

confidence: 99%

“…Pregnancy itself induces a transient immune suppression, which seems to increase the vulnerability of pregnant women to viral infections (5). Parvovirus B19 infections during pregnancy are mostly asymptomatic (1,2). But in approximately 5-10% of pregnant women with primary HPV B19 infection, may result in complications including severe fetal anemia, non-immune hydrops fetalis, abortion and intrauterine fetal death.…”

Section: Introductionmentioning

confidence: 99%

“…The important clinical manifestation of HPV B19 primary infection in human is erythema infectiosum (fifth disease) usually in children and acute polyarthralgia in adults. Since the virus replicates in the nucleus of erythroid precursor cells and is cytolytic, it causes a transient cessation of red blood cell production, so infection leads to transient aplastic crisis in persons with underlying abnormalities in erythropoiesis, and hemoglobin disorders (1)(2) A common mode of parvovirus B19 transmission is through contact with respiratory secretions or aerosol. Transmission via blood products may also occur (3).…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Parvovirus B19 Antibodies in Young Women, Sanandaj, Iran

2013

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Background and Aims: Human parvovirus B19 may transmit to the fetus via the placenta during pregnancy and cause serious complications such as severe fetal anemia, non-immune hydrops fetalis, and even intrauterine fetal death. The aim of this study was to determine the seroprevalence of parvovirus B19 antibodies among young women, Sanandaj, Iran. Materials and Methods: Ninety young women (15-40 years old) referring to clinical laboratory, Sanandaj, Iran, from January 2013 until June 2014 participated in this cross sectional study. In a questionnaire demographic data including age, job, education, place of residence, and history of illness, medications, pregnancy, history of abortion, and blood transfusion were collected. Women's sera were screened for parvovirus B19 IgM and IgG antibodies using ELISA test. The collected data and ELISA results were entered to SPSS statistical software and analyzed using t-test, one-way ANOVA with Tukey post hoc and Chisquire. Results: Prevalence of parvovirus B19 IgG and IgM antibodies were 46.7% and 3.3%, respectively in our study population. There were no association between parvovirus antibodies and the demographic variables using t-test, and one-way ANOVA with Tukey post hoc and Chi-squire. Conclusion: We found that more than fifty percent of the subjects were susceptible to parvovirus B19. Also, IgM antibody was positive in 3.3% of women, indicates that there is an active transmission of the virus in our population. Therefore, if this infection occurs during pregnancy may be harmful to the fetus. Paying more attention is needed to determine the B19 immunity, especially in young women ready for marriage and pregnancy.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Parvovirus B19 Antibodies in Young Women, Sanandaj, Iran

2013

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Prevalence of anti‐parvovirus B19 IgG and IgM and parvovirus B19 viremia in pregnant women in an urban area of Northern Italy

Massimo¹,

Claudia²,

Cerulli³

et al. 2022

Journal of Medical Virology

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Parvovirus B19 (B19V) infection in pregnancy is mostly asymptomatic, but can cause complications including abortion and fetal hydrops. Although its infection is ubiquitous, seroprevalence among pregnant women varies according to different geographical areas. Since seroprevalence data in Italy are limited, the prevalence of antibodies and DNA in pregnant women was evaluated retrospectively, correlating the clinical situation of mothers and newborns. One thousand eight hundred and ninety-three sequential sera were examined from pregnant women (60.8% in the first trimester, 16.6% in the second one, and 22.6% in the third one, respectively) for anti-B19V IgG and IgM (confirmed by immunoblot); 1402 (74.1%) were of Italian origin and 491 (25.9%) non-Italian women. Molecular tests were used to search for viral genome. One thousand three hundred and fifteen (69.5%) samples were IgG-positive, 21 (1.1%) IgM-positive, and 578 (30.5%) nonimmune. The difference in IgG seroprevalence between Italian (71.1%) and non-Italian women (64.8%) was statistically significant. Of the 21 IgM-positive women, 16 were confirmed positive also by immunoblot (prevalence: 0.8%), of which 11 were viraemic (prevalence: 0.6%; mean 1.3 × 10 4 geq/ml). Mothers were asymptomatic, and the newborns had no clinical signs of congenital infection. IgG seroprevalence in Italy is high, with differences between Italian women and non-Italian women from geographic areas with lower endemic levels of B19V. The consistent migratory flows in place could lead to an increase in the number of susceptible women. The prevalence of viremia is low, and has not been associated with evident fetal damage at birth.

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