Seroprevalence of <i>Toxoplasma gondii</i>, Rubella virus and Cytomegalovirus among pregnant women and the importance of avidity assays

Şirin, Mümtaz Cem; Ağuş, Neval; Yılmaz, Nisel; Bayram, Arzu; Derici, Yeşer Karaca; Şamlıoğlu, Pınar; Hanci, Sevgi Yılmaz; Doğan, Güliz

doi:10.15537/smj.2017.7.18182

Cited by 39 publications

(39 citation statements)

References 15 publications

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“…Gebelik sürecinde özellikle ilk trimesterde fetusta konjenital malformasyonlara yol açabilen infeksiyonların geçirilmesi, dünyada özellikle gelişmekte olan ülkelerde ölü doğumların yaklaşık yarısının nedenidir 1 . Bu infeksiyonlar arasında yer alan TORCH (Toxoplasma gondii, Rubellavirüs, Cytomegalovirüs) grubunun prevalansı çok yüksektir 2 . Bu infeksiyonlardan Toxoplasma gondii (T. gondii) fetusta görme-işitme gibi duyusal kayıplara, mental ve psikomotor geriliklere, hematolojik problemlere, hepatosplenomegaliye veya fetusun ölümüne yol açabilir 3 .…”

Section: Introductionunclassified

Diyarbakır İlindeki Gebe Kadınlarda Toksoplazma, Rubella ve Sitomegalovirus Seroprevalansı

Obut¹,

Doğan²,

Bademkıran³

et al. 2019

Dicle Tıp Dergisi

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Öz Amaç: Bu çalışmada; gebelerde, Toxoplasma gondii, Rubella virüs ve Cytomegalovirus infeksiyonlarının bölgemizdeki seroprevalanslarının belirlemesi amaçlanmıştır. Yöntemler: Bu çalışmada hastanemize Eylül 2016 ile Haziran 2018 tarihleri arasında kadın hastalıkları ve doğum polikliniklerine ilk prenatal vizite gelen 18-45 yaş arası gebeler dahil edildi. Bu hastalardan Toxoplasma gondii, Rubella ve Cytomegalovirus virüs serolojisi çalışılanların test sonuçları retrospektif olarak incelendi. Bulgular: Toxoplasma gondii antikorları açısından 8175 hastanın 2853' inde (%34,9) anti toksoplazma gondii IgG antikorları, 91' inde (%1,1) anti Toxoplasma gondii IgM antikorları pozitif olarak saptandı. Cytomegalovirus antikorları açısından 2797 hastanın 2775' inde (%99,2) anti Cytomegalovirus IgG, 20' sinde (%0,7) anti Cytomegalovirus IgM pozitif olarak saptandı. Rubella virüs antikorları açısından 8158 hastanın 7677' sinde (%94,1) anti Rubellavirus IgG, 5' inde (%0,1) anti Rubellavirus IgM pozitif olarak saptandı. Sonuç: Bu çalışmada hastanemize başvuran gebelerin çoğunun toksoplazma seronegatif (%65,1) olduğu tespit edildi. Rubella seroprevalansı (%94,1) Türkiye verileri ile uyumludur. Gebelerin Cytomegalovirus seroprevalansı için seropozitiflik oranı (%99,2) dünya verileri ile uyumludur.

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Section: Introductionunclassified

Diyarbakır İlindeki Gebe Kadınlarda Toksoplazma, Rubella ve Sitomegalovirus Seroprevalansı

Obut¹,

Doğan²,

Bademkıran³

et al. 2019

Dicle Tıp Dergisi

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“…In an environment where contact with the infectious agent can be frequent, avidity tests must be carried out to guide the behavior to be followed. 13 The IgG avidity test remains an essential orientation element despite the difficulty of access to this test for Madagascar. The question of therapeutic abortion depends on the result of this IgG avidity test.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, attitude, and practice of care providers about congenital rubella syndrome

Ravaoarisoa¹,

Andriatahina²,

Randriananahirana³

et al. 2020

Int J Res Med Sci

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Background: Behaviour of healthcare providers when facing an illness is an important part of their struggle. The aim of this study was to assess the level of knowledge, the attitude and the practice of health care providers regarding to the Congenital Rubella Syndrome.Methods: Authors did a descriptive study on the knowledge, the attitude and the practice of healthcare providers about Congenital Rubella Syndrome with 161 healthcare providers working in 8 hospitals in Madagascar. A self-introduced survey was used to collect the data.Results: There were 87% of all healthcare providers included in the study, who said that rubella in the first trimester of pregnancy was the cause of this syndrome for child, 87% knew at least 2 of the 3 major signs of Congenital Rubella Syndrome and more than 80% had a good knowledge of the criteria for diagnosing cases (suspected, clinically confirmed, laboratory confirmed). The referral to a hospital or to a specialist was the most proposed for the management of the case of Congenital Rubella Syndrome. The prescription of an IgG avidity for rubella and advising abortion were the main propositions for mothers having a positive test at the first trimester of pregnancy.Conclusions: A fairly satisfactory level of knowledge of healthcare providers was noted.

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“…Powstałe kompleksy stają się stabilne w obecności mocznika dzięki siłom elektrostatycznym, oddziaływaniom hydrofobowym, siłom Van der Waalsa i wiązaniom wodorowym. Przykładowo, w przypadku toksoplazmozy czas potrzebny na przejście z niskiej do wysokiej awidności wynosi około 12-16 tygodni, zatem przeciwciała o wysokiej awidności występują w fazie przewlekłej zarażenia (3,7,15).…”

Section: Discussionunclassified

“…W dostępnym piśmiennictwie istnieją liczne doniesienia, o bardziej lub mniej udanych próbach zastosowania indeksu awidności przeciwciał klasy IgG do rozróżnienia ostrej fazy choroby od fazy przewlekłej również w przebiegu takich chorób jak: leszmianioza trzewna, strongyloidoza, toksokaroza, salmoneloza bydła, gruźlica, zakażenie wirusami opryszczki, HCV, Epstein-Barr, HIV, różyczki, West Nile i CMV (3,9,10,15,16,18,19,20). Trzeba mieć jednak na uwadze fakt, że w przypadku serodiagnostyki toksoplazmozy opisano kilka metod oceny awidności przeciwciał (2,13).…”

Section: Dyskusjaunclassified

Avidity of IgG class antibodies to Francisella tularensis in the course of tularemia in humans

Rastawicki¹,

Śmietańska²,

Rokosz‐Chudziak³

et al. 2019

Med Dosw Mikrobiol

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Introduction: Tularemia is a highly infectious zoonotic disease caused by Gram-negative bacterium Francisella tularensis. The microbiological diagnosis of tularemia is based mainly on serological investigations. The present study was undertaken to determine the avidity of IgG class antibodies to Francisella tularensis in the course of tularemia in humans and to evaluate its value for estimation of the phase of diseases. Methods: Fifty two serum samples obtained from 40 patients with tularemia were tested by in-house ELISA in duplicate in the same plate, without and after the 0.5 h incubation with 8M urea. The age of the subjects was between 6 and 77 years. From one patient, a 9-years-old girl with oculoglandular form of tularemia, five serum samples were taken, respectively after 0.5, 1.5, 3, 6 and 12 months from the beginning of the first clinical symptoms. Results: The results of the study showed higher values of the avidity index (AI) of IgG antibodies for F. tularensis, often exceeding the value of 0.9, in children and adolescents than in adults. The examination of serum samples obtained 2-3 times in the course of tularemia from few patients did not show significant differences in the level of avidity index depending on the period of the disease. However, in five serum samples obtained from a 9-years-old girl in the different phases of tularemia the avidity index showed increasing values (0.51, 0.80, 0.92, 0.90 and 0.94, respectively). Conclusions: The avidity index of IgG may be helpful in excluding recent infection, but its usefulness in detecting an active phase of invasion requires further research.

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Seroprevalence of Toxoplasma gondii, Rubella virus and Cytomegalovirus among pregnant women and the importance of avidity assays

Cited by 39 publications

References 15 publications

Diyarbakır İlindeki Gebe Kadınlarda Toksoplazma, Rubella ve Sitomegalovirus Seroprevalansı

Diyarbakır İlindeki Gebe Kadınlarda Toksoplazma, Rubella ve Sitomegalovirus Seroprevalansı

Knowledge, attitude, and practice of care providers about congenital rubella syndrome

Avidity of IgG class antibodies to Francisella tularensis in the course of tularemia in humans

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