Seroprevalence of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among blood donors in Segou, Mali

Koné, Mamadou; Sidibé, E.T.; Mallé, K.K.; Beye, SA; Lurton, Grégoire; Diarra, Maryam; Dao, Sounkalo

doi:10.1684/mst.2012.0016

Cited by 9 publications

(7 citation statements)

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“…This male was already provided by other African writers in Nigeria, Mali, Niger, Ivory Coast and Cameroon [ 4 – 6 , 16 , 17 ]. The average age of our donors was similar to that reported by other African studies in Mali, Nigeria and Cameroon [ 4 , 5 , 17 ]. In our study, the overall prevalence of biomarkers studied in blood donors was 16.2%.…”

Section: Discussionsupporting

confidence: 87%

Estimation of seroprevalence of HIV, hepatitis B and C virus and syphilis among blood donors in the hospital of Aïoun, Mauritania

Boushab¹,

Limame²,

Zahra³

et al. 2017

Pan Afr Med J

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IntroductionTo estimating the seroprevalence of HIV, hepatitis B, hepatitis C and syphilis among blood donors in the Aïoun hospital.MethodsThis is a retrospective study from 1 January 2010 to 31 December 2015.ResultsOn the five-year study period, 1,123 donors were collected. Of these, 182 were HIV-positive, an overall prevalence of 16.2% with predominance in male with a sex ratio Man/Woman of 5.2. The average age of donors was 32.7 ± 10 years (range 17-73 years). The most represented that age group 21-30 years (40.5%). The seroprevalence found were 1.2% for HIV, 11.8% for HBV, HCV 0.2% and 3% for syphilis. Co-infection was found in 0.7% of which 0.5% of dual HIV HBV/Syphilis and 0.2% in HBV/HIV.ConclusionThe transmission of infectious agents related to transfusion represents the greatest threat to transfusion safety of the recipient. Therefore, a rigorous selection and screening of blood donors are highly recommended to ensure blood safety for the recipient.

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Section: Discussionsupporting

confidence: 87%

Estimation of seroprevalence of HIV, hepatitis B and C virus and syphilis among blood donors in the hospital of Aïoun, Mauritania

Boushab¹,

Limame²,

Zahra³

et al. 2017

Pan Afr Med J

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“…patients with liver disease, HIV-positive subjects, [ 11 , 18 , 19 ]) or low-risk (e.g. blood donors, [ 10 , 12 , 17 ]) subjects. Several studies have analyzed seroprevalence in pregnant women and in women of childbearing age [ 13 - 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, this study provides a detailed assessment of HB chronic infection status in a group of subjects, unselected for clinical symptoms, in Bamako-Mali. Previous studies in Mali and in West Africa have mostly addressed HB status in specific groups such as blood donors [ 10 , 12 , 17 ], pregnant women [ 13 , 16 ], or patients diagnosed with chronic active hepatitis [ 35 ]. The results show that the rate of HB carriage in the population of Bamako is in the higher range of estimates for West Africa, and that about 30% of adult carriers have HB and/or liver biomarkers that would qualify them for treatment with HB anti-viral therapies.…”

Section: Discussionmentioning

confidence: 99%

Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali

Traoré¹,

Gormally

Villar

et al. 2015

BMC Infect Dis

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BackgroundHepatitis B (HB) infection is common in Mali. However, there is little information on molecular and biochemical characteristics of HB carriers.MethodsA group of 1466 adult volunteers was recruited in the district of Bamako. Confirmed HB carriers were tested for HB viral load by quantitative PCR and HBV was genotyped by sequencing of HBS. Fibrosis and hepatitis activity were measured using the Fibrotest-Actitest. A mutation of TP53 at codon 249 (R249S), specific for exposure to aflatoxin, was detected in cell-free DNA extracted from plasma.ResultsOverall, 276 subjects were HBsAg-positive (18.8%). Among 152 subjects tested for HBV load, 49 (32.2%) had over 104 copies/mL and 16 (10.5%) had levels below the limit of detection. The E genotype was found in 91.1% of carriers. Fibrotest scores ≥ F2 were observed in 52 subjects (35.4%). Actitest scores ≥ A2 were detected in 15 subjects (10.2%) and were correlated with Fibrotest scores (p = 0.0006). Among 105 subjects tested, 60% had detectable levels of R249S copies (>40 copies/mL plasma).ConclusionChronic HB carriage in adults in Bamako district is well over epidemic threshold. About 1/3 of carriers have moderate to severe liver fibrosis and 60% have detectable aflatoxin-related TP53 R249S mutation. These results support introduction of anti-HB therapies to reduce the progression towards severe liver disease.

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“…This window, which is immunologically silent, separates the date of the contamination from the one in which the HBV markers appear, which justifies the negativity of the tests at this period, hence the interest of the PCR. Indeed, for Kone et al, the safety of blood transfusion would be ensured by strategies that should be directed towards the abandonment of family blood donation such as the promotion of volunteer donation, loyalty and the organization of donors in clubs [9]. Naila et al claim that in Pakistan the risk of HBV transmission is higher among replacement donors (family) because this category is in fact associated with poor people, who are secretly paid by the family and who conceal information during the selection interview [10].…”

Section: Discussionmentioning

confidence: 99%

Viral Hepatitis B: Seroprevalence and Genetic Diversity in Blood Donors North of Congo

Mongo-Onkouo¹,

Lepfoundzou²,

Yvonne³

et al. 2019

OJGas

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Introduction: Viral hepatitis B is the most formidable and confusing of all viral hepatitis, given its cirrhogenic and carcinogenic potential. The objective of the study is to characterize the molecular profile of hepatitis virus B in northern Congo. Materials and Methods: This was a descriptive and cross-sectional study that was carried out between January and September 2014, that is 9 months, in the establishments of the National Center for Blood Transfusion (CNTS) of the 4 departments of the north of the Congo. Epidemiological, serological and molecular variables (HBsAg, HBV DNA, genotypes and subtypes) were studied. The HBs antigen was searched by rapid test and confirmed by ELISA. For all positive donors, conventional and specific gene extraction and amplification techniques were performed for the identification of genotypes and subtypes from the serum. Results: A total of 892 donors were included. The average age was 35.36 ± 12.36 years with extremes ranging from 18 to 65 years old. The sex ratio

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Seroprevalence of human immunodeficiency virus, hepatitis B virus and hepatitis C virus among blood donors in Segou, Mali

Cited by 9 publications

References 0 publications

Estimation of seroprevalence of HIV, hepatitis B and C virus and syphilis among blood donors in the hospital of Aïoun, Mauritania

Estimation of seroprevalence of HIV, hepatitis B and C virus and syphilis among blood donors in the hospital of Aïoun, Mauritania

Molecular characteristics of Hepatitis B and chronic liver disease in a cohort of HB carriers from Bamako, Mali

Viral Hepatitis B: Seroprevalence and Genetic Diversity in Blood Donors North of Congo

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