Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus, Hepatitis C Virus, and Treponema pallidum Infections among Blood Donors on Bioko Island, Equatorial Guinea

Xie, Dong‐De; Li, Jian; Chen, Jiangtao; Eyi, Urbano Monsuy; Matesa, Rocio Apicante; Obono, Maximo Miko Ondo; Ehapo, Carlos Sala; Yang, Li‐Ye; Yang, Hui; Yang, Haiyan; Lin, Min

doi:10.1371/journal.pone.0139947

Cited by 47 publications

(53 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to our findings, the overall incidence of HIV among blood donors was much lower compared to other studies conducted elsewhere in Africa (4,(15)(16)(17)(18). However, it was higher than the 1.37% obtained in Nigeria (19), 0.014 % in Libya (20), 0.6% in Eritrea (21), and 0.00% Egypt (22).…”

Section: Description Of Blood Donorscontrasting

confidence: 53%

“…Safe and reliable transfusion services remain largely unavailable to the world's poorest populations, particularly in sub-Saharan Africa (3). Despite high demands for blood supplies, Malawi faces a serious problem of inadequate blood supplies collected from voluntary blood donors due to the high burden of HIV, HBV, HCV, malaria and other infections in the general population (4). Also, access to safe blood is limited due to limited resources, inadequate screening facilities and shortage of trained personnel (5,6).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence and Determinants of Transfusion-Transmissible Infections in Voluntary Blood Donors in Malawi, 2005-2015

Kinge¹

2019

Preprint

View full text Add to dashboard Cite

Background Blood transfusion has been associated with a high risk of transfusion-transmissible infections (TTIs). These infections pose great threats to the availability and safety of blood supply for transfusion, particularly in sub-Saharan Africa (SSA) where the burden of disease is alarmingly high. We describe the incidence and determinants of TTIs to help target interventions for safety and increased access to safe blood. Methods This was secondary data analysis of a cohort of blood donors from the Malawi Blood Transfusion Service (MBTS) who donated blood from 2005–2015. Incidence was obtained by dividing the number of new cases by the total person-years at risk and survival probabilities computed by Kaplan-Meier estimates. Logistic regressions were used for risk factors. Results We analysed data from 47,075 registered blood donors of which the majority were male (84%) with a median age of 22 years (IQR=18–22). Of the registered donors, 3,439 (7.31%) were infected with at least one TTI (HIV, HCV or HBV). HBV was the most common TTI with 2.63% (n=1,238), followed by HIV with 1.74% (n=818) and HCV with 1.28% (n=602). Overall, TTI incidence was 43.4 per 10,000. Donors aged 20–24 (OR= 2.15, 95% CI= 1.35–3.40), and 30–34 (OR= 2.68, 95% CI= 1.67–4.32), males (OR= 1.65; 95% CI= 1.47–1.85), and married donors (OR= 1.93; 95% CI= 1.38–2.69) had significantly higher odds of TTI in the multivariate logistic model. Infection with syphilis was a common significant risk factor for incident HIV (OR= 2.62, 95% CI= 1.57–4.38), HCV (OR= 2.03, 95% CI= 1.04–3.98), and HBV (OR= 1.71, 95% CI= 1.01–2.89). Conclusion The overall incidence of TTIs in the Malawian donor population is comparatively low. The incidence of HIV, HCV and HBV is high in males, the unemployed, donors living in the Central Region, involved in high-risk sexual behaviour, and co-infected with syphilis. HBV is most common among supposedly healthy donors, followed by HIV and HCV. TTI therefore, remains a cause for concern toward availability and safe blood supply. Implementation of strict and proper donor selection criteria and continuous screening for TTI indicators can help maximise safe blood supply and transfusion.

show abstract

Section: Description Of Blood Donorscontrasting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Incidence and Determinants of Transfusion-Transmissible Infections in Voluntary Blood Donors in Malawi, 2005-2015

Kinge¹

2019

Preprint

View full text Add to dashboard Cite

show abstract

“…La séroprévalence du VIH, de l'AgHBs, du VHC et de la syphilis n'était pas associée au sexe des donneurs de sang même si des fréquences plus élevées du VIH et de la syphilis ont été observées chez les donneurs de sexe féminin que chez ceux de sexe masculin ; alors que des fréquences plus élevées de l'AgHBs et du VHC ont été obtenues chez les donneurs hommes comparativement aux donneurs femmes. (Nambei et al, 2016).Une séroprévalence encore plus élevée de 21,5% a été rapportée chez les donneurs de sang en Guinée Équatoriale (Xie et al, 2015). La différence entre ces séroprévalences pourrait refléter une épidémiologie distincte de la syphilis entre les différentes populations d'étude (Nagalo et al, 2011).…”

Section: Introductionunclassified

Séroprévalence du virus de l’immunodéficience humaine, des virus des hépatites B et C et de <i>Treponema pallidum</i> chez les donneurs de sang dans une zone rurale au sud-est Gabon (Koula-Moutou)

Tonda¹,

Mickala²,

Mombo³

et al. 2017

J. App. Bioscience.

View full text Add to dashboard Cite

show abstract

“…Interestingly, 29 blood donors were found to be co-infected with HIV and HBV while 8 donors were co-infected with HIV and HCV, as well as HBV and HCV each. This study, for the first time, reported the seroprevalence of HIV, HBV, and HCV in blood donors from Bioko island [180].…”

Section: Equatorial Guineamentioning

confidence: 90%

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

et al. 2020

View full text Add to dashboard Cite

Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.

show abstract

Seroprevalence of Human Immunodeficiency Virus, Hepatitis B Virus, Hepatitis C Virus, and Treponema pallidum Infections among Blood Donors on Bioko Island, Equatorial Guinea

Cited by 47 publications

References 19 publications

Incidence and Determinants of Transfusion-Transmissible Infections in Voluntary Blood Donors in Malawi, 2005-2015

Incidence and Determinants of Transfusion-Transmissible Infections in Voluntary Blood Donors in Malawi, 2005-2015

Séroprévalence du virus de l’immunodéficience humaine, des virus des hépatites B et C et de <i>Treponema pallidum</i> chez les donneurs de sang dans une zone rurale au sud-est Gabon (Koula-Moutou)

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

Contact Info

Product

Resources

About