Séroprévalence du virus de l’immunodéficience humaine, des virus des hépatites B et C et de &lt;i&gt;Treponema pallidum&lt;/i&gt; chez les donneurs de sang dans une zone rurale au sud-est Gabon (Koula-Moutou)

Tonda, Judicaël; Mickala, Patrick; Mombo, Landry‐Erik; Mengue, Jean-Charles Etho; Mongo-Délis, Arnaud; Mbacky, Kevin; M’Batchi, Bertrand; Bisseyé, Cyrille

doi:10.4314/jab.v110i1.8

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…A significance differences exist in the frequencies of TTIs in blood donation between urban areas and rural areas in SSA which is mainly due to the profiles of the donors. In Gabon, the majority of blood donors in Koula-Moutou, a rural area, are FRD, whereas in urbans areas the number of VNRD predominates [6]. As expected in this study, we also found that all blood donations were collected from FRDs.…”

Section: Discussionsupporting

confidence: 85%

“…The overall seroprevalence of HBsAg in donors was 5.9% which showed a non-significant annual decrease from 6.7% in 2012 to 4.7% in 2017. The seroprevalence of HBsAg of 5.9% found in this study is higher than those of 3.3% reported among Koula-Moutou blood donors in a previous study [6] and the 3.8% reported in Cameroon [23]. Seroprevalence of HBsAg was lower than that of 7.28% reported recently in a study in Libreville blood donors [3].…”

Section: Discussioncontrasting

confidence: 82%

“…In a recent report, a prevalence of 7.28% for HBsAg was reported among first-time donors in Libreville, whilst a 4.1%, 4.9% were reported in the general population for HIV and HCV infections respectively [3-5]. In a previous study conducted in Koula-Moutou, a rural area, the seroprevalences of 1.3%, 3.3%, 4.9% and 1.6% for HIV, HBV, HCV and syphilis were reported, respectively [6]. Given that little is known on the epidemiology of transfusion transmitted infections (TTIs) in rural areas of Gabon.…”

Section: Introductionmentioning

confidence: 99%

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Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Bisseyé¹,

Mombo²,

Bie³

et al. 2018

Pan Afr Med J

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Introduction Blood-borne pathogens such as human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) viruses and Treponema pallidum remain a major public health problem in sub-Saharan Africa. The purpose of this study was to assess the frequency and clinical implications of HIV, HBV, HCV and Treponema pallidum markers in blood donors in a rural area of Southeast Gabon (Koula-Moutou) from 2012 to 2017. Methods Hepatitis B surface antigen (HBsAg), anti-HIV, anti-HCV and anti- Treponema pallidum antibodies were screened using rapid diagnostic tests (RDTs). Results Of a total of 5,706 blood donors, 1,054 (18.5%) were seropositive for at least one infectious marker and 59 (5.6%) had serologic evidence of multiple infections. The overall seroprevalence of HIV, HBsAg, HCV, and syphilis was 3.1%; 5.9%; 6.2% and 3.3%, respectively. HIV, syphilis and HCV distributions were associated with neither the sex nor the age of the donors. Only HBsAg seroprevalence was significantly higher in donors of the age group 26-35 years old compared to donors of the age group 36-45 years (OR = 1.43 (95% CI: 1.01-2.04), P = 0.045). There was a significant increase in the frequencies of HIV and syphilis and a regression of HBsAg and HCV among blood donors. Conclusion This study presents the epidemiology of the main pathogens detected in blood donors in a rural area in Gabon. We found that the overall distribution of transfusion transmitted infectious diseases were lower than those observed in the general population but could be underestimated due to the use of RDTs in the screening process of the blood donations.

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

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Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Bisseyé¹,

Mombo²,

Bie³

et al. 2018

Pan Afr Med J

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“…In Central Africa, HBV screening is limited to testing for HBsAg, as it can be detected cheaply and reliably using a rapid test, an ELISA or a chemiluminescence-based test [17]. In sub-Saharan Africa, the donor history questionnaires (DHQ) currently in use are generally based on risk factors identified elsewhere [15][16][17][18], and national evaluations of their effectiveness in developing a more cost-effective donor selection process are rare [8].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B blood safety policy in endemic areas of Gabon a resource-limitted settings

MAULOT-BANGOLA,

FOKAM,

MANGALA

et al. 2023

Preprint

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Background : Transfusion-transmissible infections (TTIs) pose a significant challenge for the availability and safety of blood transfusion. Therefore, more efforts are required to ensure the safety of blood supply and transfusions. HBV has a worldwide distribution and it is endemic in some regions of Estuaire Gabon. The risk of transmission through asymptomatic blood donors, particularly in endemic areas should be considered and appropriately managed. Objective : The main objective of this study was determining the seroprevalence rates of HBV infections rates among voluntary donors from different areas in Estuaire Gabonand we performed a systematic review to identify proportion and predictors of transmissible infections among Gabonese blood donors and community setting in Gabon. Methods : This cross sectional study was conducted at the Gabonese Blood Transfusion Centre, from June to August 2020. After taking informed consent, a total of 1610 replacements and voluntaryblood donors were screened for HBsAg, using Enzyme-Linked ImmunoSorbent Assay (ELISA) and Chemiluminescence-based assay. We conducted a systematic literature review of proportion of TTIs among blood donors and communityin high burden settings. Results : The prevalence of HBV infection among first-time donors was 55 per 1,000, and the highest for HBV infectionwere in donations from replacement volunteers. A significant difference was observed between first-time volunteers and the replacement volunteers (p <0.0001). Most of the HBsAg seropositive blood donors, 194, 186, per 1,000, were from northern and northern-western regions, respectively. In addition, we identified 7 risk factors including modes of blood donations, residence in endemic area, male gender, Hematological parameters history, age, occupation and blood donation refusal. Conclusion: The Seroprevalence of HBVamong Gabonese blood donors in the regions of our study still is considerable. Deferral based on a history of HBVexposure in an endemic area might prevent transfusion risk from an emerging disease in the HBVendemic area.

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“…Syphilis remains a major public health problem in SSA, even though averaged seroprevalence appears to have decreased in Central Africa from 5.5 to 1%, while in Eastern and Southern Africa it has increased from 0.3 to 0.9% [6]. Very few recent studies have been conducted on the epidemiology of syphilis in Gabon [7, 8]. Previous studies have shown seroprevalence of 13.3% in Franceville adults in 1988 [9]; in 1989, 11.4% in pregnant women [10] and 8% in a semi-rural population [11] and 4.6 and 2.1% in first-time blood donors in 2009 and 2015, respectively [8].…”

Section: Introductionmentioning

confidence: 99%

Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016

et al. 2019

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BackgroundVery few studies have been conducted on the seroprevalence of syphilis in Gabon. According to the World Health Organization, the average seroprevalence of syphilis has declined from 5.5 to 1.1% in Central Africa. The aim of this study was to test the hypothesis that syphilis decreased in Gabon between 2004 and 2016 and to identify factors involved in this pattern by testing a large sample of first-time blood donors in the capital Libreville.MethodsThe detection of Treponema pallidum was done using a Rapid Plasma Reagin test (RPR) and confirmed by an ELISA test using the Biorad Syphilis Total Antibody EIA II kit or BioMerieux Trepanostika TP recombinant. Assays were performed by dedicated technicians according to manufacturers’ recommendations and following the laboratory standard operating procedures. Test results were manually transferred into the laboratory Excel files and hand-written in the laboratory logbook for syphilis testing. Logistic regression was used to assess the impact of sociodemographic characteristics on syphilis marker seroprevalence in both univariate and multivariable analysis. Odds ratios (OR) and 95% confidence intervals were calculated.ResultsThe seroprevalence of syphilis markers was 8.4% (95% CI = 7.9–8.9) in 2004 and 2.4% (95% CI = 2.1–2.7) in 2016. The difference was significant [OR = 3.78; 95% CI (3.26–4.38); P < 0.001]. The decrease in syphilis seroprevalence was significant in both women and men and in each age group in univariate analysis. In multivariable analysis, controlling for all sociodemographic factors, the decrease in syphilis seroprevalence from 2004 to 2016 remained significant (OR = 3.29; 95% CI = 2.88–3.88, P < 0.001). The seroprevalence of syphilis decreased significantly in men compared to women and young donors compared to donors aged ≥36 years.ConclusionsThis study shows a significant decline in syphilis seroprevalence in first-time blood donors in Libreville, Gabon. Government actions, including multiple HIV prevention activities, are a likely part of this decline.

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Séroprévalence du virus de l’immunodéficience humaine, des virus des hépatites B et C et de <i>Treponema pallidum</i> chez les donneurs de sang dans une zone rurale au sud-est Gabon (Koula-Moutou)

Abstract: Tonda et al., J. Appl. Biosci. 2017 Séroprévalence du virus de l'immunodéficience humaine, des virus des hépatites B et C et de Treponema pallidum chez les donneurs de sang dans une zone rurale au sud-est Gabon

Cited by 7 publications

References 15 publications

Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Trends of blood-borne infectious diseases in a rural blood donation center of southeast Gabon (Koula-Moutou)

Hepatitis B blood safety policy in endemic areas of Gabon a resource-limitted settings

Decline in the seroprevalence of syphilis markers among first-time blood donors in Libreville (Gabon) between 2004 and 2016

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